Prostate cancer is one of the most frequently diagnosed cancer in men. Treatment by radical prostatectomy, radiotherapy and anti-androgen drugs is successful in patients with localized cancer. However, prolonged androgen deprivation often leads to hormone refractory condition, associated with disease relapse. ErbB1 and ErbB2 activity has been correlated with androgen-independence. We determined the effects of GW2974, a dual inhibitor of ErbB-1 and ErbB-2 tyrosine kinase activity, on growth, NSE, chromogranin A and osteopontin cytosol content in the androgen-independent prostate cancer cell line PC-3. We found that PC-3 cell growth was inhibited by GW2974, whereas NSE and chromogranin A cell contents were stimulated and osteopontin cytosol level was not affected. The present data may have clinical implications for the treatment of advanced prostate cancer.

Effects of the ErbB1/ErbB2 kinase inhibitor GW2974 on andrgen-independent prostate cancer PC-3 cell line growth and NSE, chromogranin A and osteopontin content / Terracciano, D; Mazzarella, C; DI CARLO, Angelina; Mariano, A; Ferro, M; DI LORENZO, G; Giordano, A; Altieri, V; DE PLACIDO, S; Macchia, V.. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - 24(1):(2010), pp. 213-217. [10.3892/or_00000848]

Effects of the ErbB1/ErbB2 kinase inhibitor GW2974 on andrgen-independent prostate cancer PC-3 cell line growth and NSE, chromogranin A and osteopontin content

DI CARLO, ANGELINA;
2010

Abstract

Prostate cancer is one of the most frequently diagnosed cancer in men. Treatment by radical prostatectomy, radiotherapy and anti-androgen drugs is successful in patients with localized cancer. However, prolonged androgen deprivation often leads to hormone refractory condition, associated with disease relapse. ErbB1 and ErbB2 activity has been correlated with androgen-independence. We determined the effects of GW2974, a dual inhibitor of ErbB-1 and ErbB-2 tyrosine kinase activity, on growth, NSE, chromogranin A and osteopontin cytosol content in the androgen-independent prostate cancer cell line PC-3. We found that PC-3 cell growth was inhibited by GW2974, whereas NSE and chromogranin A cell contents were stimulated and osteopontin cytosol level was not affected. The present data may have clinical implications for the treatment of advanced prostate cancer.
2010
PC3; NSE; GW2974; ErbB1; ErbB2
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of the ErbB1/ErbB2 kinase inhibitor GW2974 on andrgen-independent prostate cancer PC-3 cell line growth and NSE, chromogranin A and osteopontin content / Terracciano, D; Mazzarella, C; DI CARLO, Angelina; Mariano, A; Ferro, M; DI LORENZO, G; Giordano, A; Altieri, V; DE PLACIDO, S; Macchia, V.. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - 24(1):(2010), pp. 213-217. [10.3892/or_00000848]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/12687
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