The most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Therefore, their dysregulation can expose individuals to malignancies. It has been proved that miRNA expression is dysregulated in different types of tumors, like thyroid cancers, and can be the cause of tumor initiation and progression. In this paper, we have reviewed the available data on miRNA dysregulation in different thyroid tumors including papillary, follicular, anaplastic, and medullary thyroid carcinomas aiming to introduce the last updates in miRNAs-thyroid cancer relation.

The role of microRNAs in different types of thyroid carcinoma. A comprehensive analysis to find new miRNA supplementary therapies / Pishkari, S.; Paryan, M.; Hashemi, M.; Baldini, E.; Mohammadi-Yeganeh, S.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 41:3(2018), pp. 269-283. [10.1007/s40618-017-0735-6]

The role of microRNAs in different types of thyroid carcinoma. A comprehensive analysis to find new miRNA supplementary therapies

Baldini, E.
;
2018

Abstract

The most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Therefore, their dysregulation can expose individuals to malignancies. It has been proved that miRNA expression is dysregulated in different types of tumors, like thyroid cancers, and can be the cause of tumor initiation and progression. In this paper, we have reviewed the available data on miRNA dysregulation in different thyroid tumors including papillary, follicular, anaplastic, and medullary thyroid carcinomas aiming to introduce the last updates in miRNAs-thyroid cancer relation.
2018
Anaplastic thyroid carcinoma; Follicular thyroid carcinoma; Medullary thyroid carcinoma; microRNA; Papillary thyroid carcinoma; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Prognosis; Thyroid Neoplasms; Endocrinology, Diabetes and Metabolism; Endocrinology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The role of microRNAs in different types of thyroid carcinoma. A comprehensive analysis to find new miRNA supplementary therapies / Pishkari, S.; Paryan, M.; Hashemi, M.; Baldini, E.; Mohammadi-Yeganeh, S.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 41:3(2018), pp. 269-283. [10.1007/s40618-017-0735-6]
File allegati a questo prodotto
File Dimensione Formato  
Pishkari_MicroRNAs-thyroid-carcinoma_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 959.08 kB
Formato Adobe PDF
959.08 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1264697
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 64
social impact