Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches tominimize treatment sequelaewhile preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients.

Advances in the management of HPV-related oropharyngeal cancer / De Felice, F.; Tombolini, V.; Valentini, V.; de Vincentiis, M.; Mezi, S.; Brugnoletti, O.; Polimeni, A.. - In: JOURNAL OF ONCOLOGY. - ISSN 1687-8450. - 2019:(2019), pp. 1-8. [10.1155/2019/9173729]

Advances in the management of HPV-related oropharyngeal cancer

De Felice, F.
Primo
;
Tombolini, V.
Secondo
;
Valentini, V.;de Vincentiis, M.;Mezi, S.;Brugnoletti, O.
Penultimo
;
Polimeni, A.
Ultimo
2019

Abstract

Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches tominimize treatment sequelaewhile preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients.
2019
HPV; cancer patient; oropharyngeal cancer
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Advances in the management of HPV-related oropharyngeal cancer / De Felice, F.; Tombolini, V.; Valentini, V.; de Vincentiis, M.; Mezi, S.; Brugnoletti, O.; Polimeni, A.. - In: JOURNAL OF ONCOLOGY. - ISSN 1687-8450. - 2019:(2019), pp. 1-8. [10.1155/2019/9173729]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1260121
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