Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.

Non-coding RNA networks in cancer / Anastasiadou, Eleni; Jacob, Leni S; Slack, Frank J. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - 18:1(2018), pp. 5-18. [10.1038/nrc.2017.99]

Non-coding RNA networks in cancer

Anastasiadou, Eleni;
2018

Abstract

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
2018
Animals; humans; neoplasms; RNA processing, post-transcriptional; RNA, untranslated; signal transduction; transcription, genetic
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Non-coding RNA networks in cancer / Anastasiadou, Eleni; Jacob, Leni S; Slack, Frank J. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - 18:1(2018), pp. 5-18. [10.1038/nrc.2017.99]
File allegati a questo prodotto
File Dimensione Formato  
Anastasiadou_Nature-Reviews-Cancer_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 584.26 kB
Formato Adobe PDF
584.26 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1257458
Citazioni
  • ???jsp.display-item.citation.pmc??? 675
  • Scopus 1292
  • ???jsp.display-item.citation.isi??? 1192
social impact