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The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines / Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K; Ayre, D Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N; Baxter, Amy A; Bebawy, Mary; Beckham, Carla; Bedina Zavec, Apolonija; Benmoussa, Abderrahim; Berardi, Anna C; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borràs, Francesc E; Bosch, Steffi; Boulanger, Chantal M; Breakefield, Xandra; Breglio, Andrew M; Brennan, Meadhbh Á; Brigstock, David R; Brisson, Alain; Broekman, Marike Ld; Bromberg, Jacqueline F; Bryl-Górecka, Paulina; Buch, Shilpa; Buck, Amy H; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzás, Edit I; Byrd, James Bryan; Camussi, Giovanni; Carter, David Rf; Caruso, Sarah; Chamley, Lawrence W; Chang, Yu-Ting; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R; Clayton, Aled; Clerici, Stefano P; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank Aw; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D'Souza-Schorey, Crislyn; Das, Saumya; Datta Chaudhuri, Amrita; de Candia, Paola; De Santana, Eliezer F; De Wever, Olivier; Del Portillo, Hernando A; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R; Driedonks, Tom Ap; Duarte, Filipe V; Duncan, Heather M; Eichenberger, Ramon M; Ekström, Karin; El Andaloussi, Samir; Elie-Caille, Celine; Erdbrügger, Uta; Falcón-Pérez, Juan M; Fatima, Farah; Fish, Jason E; Flores-Bellver, Miguel; Försönits, András; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gámez-Valero, Ana; Gardiner, Chris; Gärtner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah Ci; Görgens, André; Gorski, Sharon M; Greening, David W; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F; Hochberg, Fred H; Hoffmann, Karl F; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K; Jacobsen, Soren; Jay, Steven M; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M; Jones, Jennifer C; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-Ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J; Kornek, Miroslaw; Kosanović, Maja M; Kovács, Árpád Ferenc; Krämer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor V; Kusuma, Gina D; Kuypers, Sören; Laitinen, Saara; Langevin, Scott M; Languino, Lucia R; Lannigan, Joanne; Lässer, Cecilia; Laurent, Louise C; Lavieu, Gregory; Lázaro-Ibáñez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac Ts; Liao, Ke; Libregts, Sten F; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Linē, Aija; Linnemannstöns, Karen; Llorente, Alicia; Lombard, Catherine A; Lorenowicz, Magdalena J; Lörincz, Ákos M; Lötvall, Jan; Lovett, Jason; Lowry, Michelle C; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R; Maas, Sybren Ln; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S; Martin-Jaular, Lorena; Martinez, M Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; Mcginnis, Lynda K; Mcvey, Mark J; Meckes, David G; Meehan, Katie L; Mertens, Inge; Minciacchi, Valentina R; Möller, Andreas; Møller Jørgensen, Malene; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, François; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C; Myburgh, Kathryn H; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P; Nolte-'t Hoen, Esther Nm; Noren Hooten, Nicole; O'Driscoll, Lorraine; O'Grady, Tina; O'Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A; Osteikoetxea, Xabier; Østergaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D Michiel; Peinado, Hector; Perut, Francesca; Pfaffl, Michael W; Phinney, Donald G; Pieters, Bartijn Ch; Pink, Ryan C; Pisetsky, David S; Pogge von Strandmann, Elke; Polakovicova, Iva; Poon, Ivan Kh; Powell, Bonita H; Prada, Ilaria; Pulliam, Lynn; Quesenberry, Peter; Radeghieri, Annalisa; Raffai, Robert L; Raimondo, Stefania; Rak, Janusz; Ramirez, Marcel I; Raposo, Graça; Rayyan, Morsi S; Regev-Rudzki, Neta; Ricklefs, Franz L; Robbins, Paul D; Roberts, David D; Rodrigues, Silvia C; Rohde, Eva; Rome, Sophie; Rouschop, Kasper Ma; Rughetti, Aurelia; Russell, Ashley E; Saá, Paula; Sahoo, Susmita; Salas-Huenuleo, Edison; Sánchez, Catherine; Saugstad, Julie A; Saul, Meike J; Schiffelers, Raymond M; Schneider, Raphael; Schøyen, Tine Hiorth; Scott, Aaron; Shahaj, Eriomina; Sharma, Shivani; Shatnyeva, Olga; Shekari, Faezeh; Shelke, Ganesh Vilas; Shetty, Ashok K; Shiba, Kiyotaka; Siljander, Pia R-M; Silva, Andreia M; Skowronek, Agata; Snyder, Orman L; Soares, Rodrigo Pedro; Sódar, Barbara W; Soekmadji, Carolina; Sotillo, Javier; Stahl, Philip D; Stoorvogel, Willem; Stott, Shannon L; Strasser, Erwin F; Swift, Simon; Tahara, Hidetoshi; Tewari, Muneesh; Timms, Kate; Tiwari, Swasti; Tixeira, Rochelle; Tkach, Mercedes; Toh, Wei Seong; Tomasini, Richard; Torrecilhas, Ana Claudia; Tosar, Juan Pablo; Toxavidis, Vasilis; Urbanelli, Lorena; Vader, Pieter; van Balkom, Bas Wm; van der Grein, Susanne G; Van Deun, Jan; van Herwijnen, Martijn Jc; Van Keuren-Jensen, Kendall; van Niel, Guillaume; van Royen, Martin E; van Wijnen, Andre J; Vasconcelos, M Helena; Vechetti, Ivan J; Veit, Tiago D; Vella, Laura J; Velot, Émilie; Verweij, Frederik J; Vestad, Beate; Viñas, Jose L; Visnovitz, Tamás; Vukman, Krisztina V; Wahlgren, Jessica; Watson, Dionysios C; Wauben, Marca Hm; Weaver, Alissa; Webber, Jason P; Weber, Viktoria; Wehman, Ann M; Weiss, Daniel J; Welsh, Joshua A; Wendt, Sebastian; Wheelock, Asa M; Wiener, Zoltán; Witte, Leonie; Wolfram, Joy; Xagorari, Angeliki; Xander, Patricia; Xu, Jing; Yan, Xiaomei; Yáñez-Mó, María; Yin, Hang; Yuana, Yuana; Zappulli, Valentina; Zarubova, Jana; Žėkas, Vytautas; Zhang, Jian-Ye; Zhao, Zezhou; Zheng, Lei; Zheutlin, Alexander R; Zickler, Antje M; Zimmermann, Pascale; Zivkovic, Angela M; Zocco, Davide; Zuba-Surma, Ewa K. - In: JOURNAL OF EXTRACELLULAR VESICLES. - ISSN 2001-3078. - 7:1(2018). [10.1080/20013078.2018.1535750]
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Théry, Clotilde;Witwer, Kenneth W;Aikawa, Elena;Alcaraz, Maria Jose;Anderson, Johnathon D;Andriantsitohaina, Ramaroson;Antoniou, Anna;Arab, Tanina;Archer, Fabienne;Atkin-Smith, Georgia K;Ayre, D Craig;Bach, Jean-Marie;Bachurski, Daniel;Baharvand, Hossein;Balaj, Leonora;Baldacchino, Shawn;Bauer, Natalie N;Baxter, Amy A;Bebawy, Mary;Beckham, Carla;Bedina Zavec, Apolonija;Benmoussa, Abderrahim;Berardi, Anna C;Bergese, Paolo;Bielska, Ewa;Blenkiron, Cherie;Bobis-Wozowicz, Sylwia;Boilard, Eric;Boireau, Wilfrid;Bongiovanni, Antonella;Borràs, Francesc E;Bosch, Steffi;Boulanger, Chantal M;Breakefield, Xandra;Breglio, Andrew M;Brennan, Meadhbh Á;Brigstock, David R;Brisson, Alain;Broekman, Marike Ld;Bromberg, Jacqueline F;Bryl-Górecka, Paulina;Buch, Shilpa;Buck, Amy H;Burger, Dylan;Busatto, Sara;Buschmann, Dominik;Bussolati, Benedetta;Buzás, Edit I;Byrd, James Bryan;Camussi, Giovanni;Carter, David Rf;Caruso, Sarah;Chamley, Lawrence W;Chang, Yu-Ting;Chen, Chihchen;Chen, Shuai;Cheng, Lesley;Chin, Andrew R;Clayton, Aled;Clerici, Stefano P;Cocks, Alex;Cocucci, Emanuele;Coffey, Robert J;Cordeiro-da-Silva, Anabela;Couch, Yvonne;Coumans, Frank Aw;Coyle, Beth;Crescitelli, Rossella;Criado, Miria Ferreira;D'Souza-Schorey, Crislyn;Das, Saumya;Datta Chaudhuri, Amrita;de Candia, Paola;De Santana, Eliezer F;De Wever, Olivier;Del Portillo, Hernando A;Demaret, Tanguy;Deville, Sarah;Devitt, Andrew;Dhondt, Bert;Di Vizio, Dolores;Dieterich, Lothar C;DOLO, Vincenza;Dominguez Rubio, Ana Paula;Dominici, Massimo;Dourado, Mauricio R;Driedonks, Tom Ap;Duarte, Filipe V;Duncan, Heather M;Eichenberger, Ramon M;Ekström, Karin;El Andaloussi, Samir;Elie-Caille, Celine;Erdbrügger, Uta;Falcón-Pérez, Juan M;Fatima, Farah;Fish, Jason E;Flores-Bellver, Miguel;Försönits, András;Frelet-Barrand, Annie;Fricke, Fabia;Fuhrmann, Gregor;Gabrielsson, Susanne;Gámez-Valero, Ana;Gardiner, Chris;Gärtner, Kathrin;Gaudin, Raphael;Gho, Yong Song;Giebel, Bernd;Gilbert, Caroline;Gimona, Mario;Giusti, Ilaria;Goberdhan, Deborah Ci;Görgens, André;Gorski, Sharon M;Greening, David W;Gross, Julia Christina;Gualerzi, Alice;Gupta, Gopal N;Gustafson, Dakota;Handberg, Aase;Haraszti, Reka A;Harrison, Paul;Hegyesi, Hargita;Hendrix, An;Hill, Andrew F;Hochberg, Fred H;Hoffmann, Karl F;Holder, Beth;Holthofer, Harry;Hosseinkhani, Baharak;Hu, Guoku;Huang, Yiyao;Huber, Veronica;Hunt, Stuart;Ibrahim, Ahmed Gamal-Eldin;Ikezu, Tsuneya;Inal, Jameel M;Isin, Mustafa;Ivanova, Alena;Jackson, Hannah K;Jacobsen, Soren;Jay, Steven M;Jayachandran, Muthuvel;Jenster, Guido;Jiang, Lanzhou;Johnson, Suzanne M;Jones, Jennifer C;Jong, Ambrose;Jovanovic-Talisman, Tijana;Jung, Stephanie;Kalluri, Raghu;Kano, Shin-Ichi;Kaur, Sukhbir;Kawamura, Yumi;Keller, Evan T;Khamari, Delaram;Khomyakova, Elena;Khvorova, Anastasia;Kierulf, Peter;Kim, Kwang Pyo;Kislinger, Thomas;Klingeborn, Mikael;Klinke, David J;Kornek, Miroslaw;Kosanović, Maja M;Kovács, Árpád Ferenc;Krämer-Albers, Eva-Maria;Krasemann, Susanne;Krause, Mirja;Kurochkin, Igor V;Kusuma, Gina D;Kuypers, Sören;Laitinen, Saara;Langevin, Scott M;Languino, Lucia R;Lannigan, Joanne;Lässer, Cecilia;Laurent, Louise C;Lavieu, Gregory;Lázaro-Ibáñez, Elisa;Le Lay, Soazig;Lee, Myung-Shin;Lee, Yi Xin Fiona;Lemos, Debora S;Lenassi, Metka;Leszczynska, Aleksandra;Li, Isaac Ts;Liao, Ke;Libregts, Sten F;Ligeti, Erzsebet;Lim, Rebecca;Lim, Sai Kiang;Linē, Aija;Linnemannstöns, Karen;Llorente, Alicia;Lombard, Catherine A;Lorenowicz, Magdalena J;Lörincz, Ákos M;Lötvall, Jan;Lovett, Jason;Lowry, Michelle C;Loyer, Xavier;Lu, Quan;Lukomska, Barbara;Lunavat, Taral R;Maas, Sybren Ln;Malhi, Harmeet;Marcilla, Antonio;Mariani, Jacopo;Mariscal, Javier;Martens-Uzunova, Elena S;Martin-Jaular, Lorena;Martinez, M Carmen;Martins, Vilma Regina;Mathieu, Mathilde;Mathivanan, Suresh;Maugeri, Marco;McGinnis, Lynda K;McVey, Mark J;Meckes, David G;Meehan, Katie L;Mertens, Inge;Minciacchi, Valentina R;Möller, Andreas;Møller Jørgensen, Malene;Morales-Kastresana, Aizea;Morhayim, Jess;Mullier, François;Muraca, Maurizio;Musante, Luca;Mussack, Veronika;Muth, Dillon C;Myburgh, Kathryn H;Najrana, Tanbir;Nawaz, Muhammad;Nazarenko, Irina;Nejsum, Peter;Neri, Christian;Neri, Tommaso;Nieuwland, Rienk;Nimrichter, Leonardo;Nolan, John P;Nolte-'t Hoen, Esther Nm;Noren Hooten, Nicole;O'Driscoll, Lorraine;O'Grady, Tina;O'Loghlen, Ana;Ochiya, Takahiro;Olivier, Martin;Ortiz, Alberto;Ortiz, Luis A;Osteikoetxea, Xabier;Østergaard, Ole;Ostrowski, Matias;Park, Jaesung;Pegtel, D Michiel;Peinado, Hector;Perut, Francesca;Pfaffl, Michael W;Phinney, Donald G;Pieters, Bartijn Ch;Pink, Ryan C;Pisetsky, David S;Pogge von Strandmann, Elke;Polakovicova, Iva;Poon, Ivan Kh;Powell, Bonita H;Prada, Ilaria;Pulliam, Lynn;Quesenberry, Peter;Radeghieri, Annalisa;Raffai, Robert L;Raimondo, Stefania;Rak, Janusz;Ramirez, Marcel I;Raposo, Graça;Rayyan, Morsi S;Regev-Rudzki, Neta;Ricklefs, Franz L;Robbins, Paul D;Roberts, David D;Rodrigues, Silvia C;Rohde, Eva;Rome, Sophie;Rouschop, Kasper Ma;Rughetti, Aurelia;Russell, Ashley E;Saá, Paula;Sahoo, Susmita;Salas-Huenuleo, Edison;Sánchez, Catherine;Saugstad, Julie A;Saul, Meike J;Schiffelers, Raymond M;Schneider, Raphael;Schøyen, Tine Hiorth;Scott, Aaron;Shahaj, Eriomina;Sharma, Shivani;Shatnyeva, Olga;Shekari, Faezeh;Shelke, Ganesh Vilas;Shetty, Ashok K;Shiba, Kiyotaka;Siljander, Pia R-M;Silva, Andreia M;Skowronek, Agata;Snyder, Orman L;Soares, Rodrigo Pedro;Sódar, Barbara W;Soekmadji, Carolina;Sotillo, Javier;Stahl, Philip D;Stoorvogel, Willem;Stott, Shannon L;Strasser, Erwin F;Swift, Simon;Tahara, Hidetoshi;Tewari, Muneesh;Timms, Kate;Tiwari, Swasti;Tixeira, Rochelle;Tkach, Mercedes;Toh, Wei Seong;Tomasini, Richard;Torrecilhas, Ana Claudia;Tosar, Juan Pablo;Toxavidis, Vasilis;Urbanelli, Lorena;Vader, Pieter;van Balkom, Bas Wm;van der Grein, Susanne G;Van Deun, Jan;van Herwijnen, Martijn Jc;Van Keuren-Jensen, Kendall;van Niel, Guillaume;van Royen, Martin E;van Wijnen, Andre J;Vasconcelos, M Helena;Vechetti, Ivan J;Veit, Tiago D;Vella, Laura J;Velot, Émilie;Verweij, Frederik J;Vestad, Beate;Viñas, Jose L;Visnovitz, Tamás;Vukman, Krisztina V;Wahlgren, Jessica;Watson, Dionysios C;Wauben, Marca Hm;Weaver, Alissa;Webber, Jason P;Weber, Viktoria;Wehman, Ann M;Weiss, Daniel J;Welsh, Joshua A;Wendt, Sebastian;Wheelock, Asa M;Wiener, Zoltán;Witte, Leonie;Wolfram, Joy;Xagorari, Angeliki;Xander, Patricia;Xu, Jing;Yan, Xiaomei;Yáñez-Mó, María;Yin, Hang;Yuana, Yuana;Zappulli, Valentina;Zarubova, Jana;Žėkas, Vytautas;Zhang, Jian-Ye;Zhao, Zezhou;Zheng, Lei;Zheutlin, Alexander R;Zickler, Antje M;Zimmermann, Pascale;Zivkovic, Angela M;Zocco, Davide;Zuba-Surma, Ewa K
2018
Abstract
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
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