Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ∼1400 human proteins have experimental evidence of RNA-binding activity. However, only ∼250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (http://rnact.crg.eu).

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data / Lang, Benjamin; Armaos, Alexandros; Tartaglia, Gian G. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 47:D1(2019), pp. D601-D606. [10.1093/nar/gky967]

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data

Tartaglia, Gian G
2019

Abstract

Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ∼1400 human proteins have experimental evidence of RNA-binding activity. However, only ∼250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (http://rnact.crg.eu).
2019
Genetics
01 Pubblicazione su rivista::01a Articolo in rivista
RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data / Lang, Benjamin; Armaos, Alexandros; Tartaglia, Gian G. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 47:D1(2019), pp. D601-D606. [10.1093/nar/gky967]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1254571
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