Rationale and Objectives: The aim of this study was to retrospectly investigate the association between different breast cancer (BC) immunohistochemical subtypes and morphological and semiquantitative kinetic analysis on breast magnetic resonance imaging (MRI) performed before surgery treatment. Specifically we aimed to assess MRI features of triple-negative breast cancer (TNBC) compared to the other BC subtypes (nTNBC). Materials and Methods: Patients undergone to breast MRI and then diagnosed with BC by core-needle biopsy were included. The MRI morphological and kinetic features were studied. Parametric and non-parametric tests were used, as appropriate. Results: Seventy-five BC patients were considered, 30 patients included in TNBC Group and 45 patients included in nTNBC Group. We found in TNBC Group a greater mean lesion size (P <0.001), a rim enhancement imaging (P=0.003), and a higher intratumoral signal intensity on T2-weighted images (P=0.03) with respect to nTNBC Group. We noticed that TNBC patients presented a lower grade of BPE when compared to the nTBC Group (P< 0.02). TNBC Group showed lower EPeak values (P=0.003) and higher SER values (P=0.02) with respect to the nTNBC Group. In addition, stratifying kinetics parameters according to the tumor grade, the TNBC Group presented higher tumor grade (G3) (P< 0.005) and this subgroup had higher SER values when compared to TNBCs showing a lower tumor grade (G1 and G2) (P=0.03). Conclusion: After validation by large-scale studies, the morphological and semiquantitative kinetic analysis on dynamic contrast enhanced MRI may help in the pretreatment risk stratification of patients with TNBC and in evidence-based clinical decision support.

Morphological and semiquantitative kinetic analysis on dynamic contrast enhanced MRI in triple negative breast cancer patients / Gigli, Silvia; Amabile, Maria Ida; David, Emanuele; De Luca, Alessandro; Grippo, Cristina; Manganaro, Lucia; Monti, Massimo; Ballesio, Laura. - In: ACADEMIC RADIOLOGY. - ISSN 1076-6332. - 26:5(2019), pp. 620-625. [10.1016/j.acra.2018.06.014]

Morphological and semiquantitative kinetic analysis on dynamic contrast enhanced MRI in triple negative breast cancer patients

Gigli, Silvia
Co-primo
;
Amabile, Maria Ida
Co-primo
;
David, Emanuele;De Luca, Alessandro;Manganaro, Lucia;Monti, Massimo
Penultimo
;
Ballesio, Laura
Ultimo
2019

Abstract

Rationale and Objectives: The aim of this study was to retrospectly investigate the association between different breast cancer (BC) immunohistochemical subtypes and morphological and semiquantitative kinetic analysis on breast magnetic resonance imaging (MRI) performed before surgery treatment. Specifically we aimed to assess MRI features of triple-negative breast cancer (TNBC) compared to the other BC subtypes (nTNBC). Materials and Methods: Patients undergone to breast MRI and then diagnosed with BC by core-needle biopsy were included. The MRI morphological and kinetic features were studied. Parametric and non-parametric tests were used, as appropriate. Results: Seventy-five BC patients were considered, 30 patients included in TNBC Group and 45 patients included in nTNBC Group. We found in TNBC Group a greater mean lesion size (P <0.001), a rim enhancement imaging (P=0.003), and a higher intratumoral signal intensity on T2-weighted images (P=0.03) with respect to nTNBC Group. We noticed that TNBC patients presented a lower grade of BPE when compared to the nTBC Group (P< 0.02). TNBC Group showed lower EPeak values (P=0.003) and higher SER values (P=0.02) with respect to the nTNBC Group. In addition, stratifying kinetics parameters according to the tumor grade, the TNBC Group presented higher tumor grade (G3) (P< 0.005) and this subgroup had higher SER values when compared to TNBCs showing a lower tumor grade (G1 and G2) (P=0.03). Conclusion: After validation by large-scale studies, the morphological and semiquantitative kinetic analysis on dynamic contrast enhanced MRI may help in the pretreatment risk stratification of patients with TNBC and in evidence-based clinical decision support.
2019
breast magnetic resonance imaging; immunohistochemical breast cancer subtypes; semi-quantitative perfusion analysis; triple negative breast cancer; radiology, nuclear medicine and imaging
01 Pubblicazione su rivista::01a Articolo in rivista
Morphological and semiquantitative kinetic analysis on dynamic contrast enhanced MRI in triple negative breast cancer patients / Gigli, Silvia; Amabile, Maria Ida; David, Emanuele; De Luca, Alessandro; Grippo, Cristina; Manganaro, Lucia; Monti, Massimo; Ballesio, Laura. - In: ACADEMIC RADIOLOGY. - ISSN 1076-6332. - 26:5(2019), pp. 620-625. [10.1016/j.acra.2018.06.014]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1252210
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