High-performance liquid chromatography (HPLC) was used for the enantiomeric separation of chiral imidazole derivatives endowed with antimycotic activity. Enantioselective columns, containing carbamates of cellulose and amylose, were used. The influence of the nature and content of an alcoholic modifier in the mobile phase was studied. The isolated enantiomers, separated on semipreparative columns, were submitted to in vitro biological investigations.
Analytical and semipreparative enantiomeric separation of azole antifungal agents by high-performance liquid chromatography on polysaccharide-based chiral stationary phases Application to in vitro biological studies / Cirilli, R.; Costi, R.; DI SANTO, R.; Ferretti, R.; LA TORRE, F.; Angiolella, L.; Micocci, M.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 942:1-2(2001), pp. 107-114. [10.1016/S0021-9673(01)01401-7]
Analytical and semipreparative enantiomeric separation of azole antifungal agents by high-performance liquid chromatography on polysaccharide-based chiral stationary phases Application to in vitro biological studies
COSTI, R.;DI SANTO, R.;ANGIOLELLA, L.;
2001
Abstract
High-performance liquid chromatography (HPLC) was used for the enantiomeric separation of chiral imidazole derivatives endowed with antimycotic activity. Enantioselective columns, containing carbamates of cellulose and amylose, were used. The influence of the nature and content of an alcoholic modifier in the mobile phase was studied. The isolated enantiomers, separated on semipreparative columns, were submitted to in vitro biological investigations.| File | Dimensione | Formato | |
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