Purpose: Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC. Methods: Peripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41–65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics. Results: The prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59–2.53, p > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°–165°)] and 16 [flexion 82.5° (range 50°–95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005–3.482, p < 0.05). Conclusions: Apo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC. Level of Evidence: III.

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity / Gumina, S.; Candela, V.; Castagna, A.; Carnovale, M.; Passaretti, D.; Venditto, T.; Giannicola, G.; Villani, C.. - In: MUSCULOSKELETAL SURGERY. - ISSN 2035-5106. - 102:Suppl 1(2018), pp. 35-40. [10.1007/s12306-018-0557-5]

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity

Gumina, S.;Candela, V.;Castagna, A.;Carnovale, M.;Passaretti, D.;Venditto, T.;Giannicola, G.;Villani, C.
2018

Abstract

Purpose: Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC. Methods: Peripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41–65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics. Results: The prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59–2.53, p > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°–165°)] and 16 [flexion 82.5° (range 50°–95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005–3.482, p < 0.05). Conclusions: Apo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC. Level of Evidence: III.
2018
adhesive capsulitis; adhesive capsulitis severity; frozen shoulder; frozen shoulder etiology; hypercholesterolemia; lipoproteins; surgery; orthopedics and sports medicine
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Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity / Gumina, S.; Candela, V.; Castagna, A.; Carnovale, M.; Passaretti, D.; Venditto, T.; Giannicola, G.; Villani, C.. - In: MUSCULOSKELETAL SURGERY. - ISSN 2035-5106. - 102:Suppl 1(2018), pp. 35-40. [10.1007/s12306-018-0557-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1249689
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