It is commonly accepted that testicular function is prevalently regulated by the hypothalamic-pituitary-gonadal axis: The pulsatile secretion of GnRH by the hypothalamus induces pituitary expression of the two gonadotropins FSH and LH, which then stimulate Sertoli and Leydig cells, respectively, therefore regulating steroidogenesis and spermatogenesis. However, a growing body of evidence has recently suggested that other hormones act on the reproductive tract since the early phases of fetal development. Anti-Müllerian hormone and INSL3 are still largely used only for research purposes despite being increasingly recognized as markers of Sertoli and Leydig cells function, respectively.

AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know? / Sansone, A; Kliesch, S; Isidori, A M; Schlatt, S. - In: ANDROLOGY. - ISSN 2047-2919. - 7:2(2019), pp. 131-138. [10.1111/andr.12597]

AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?

Sansone, A
Primo
;
Isidori, A M;
2019

Abstract

It is commonly accepted that testicular function is prevalently regulated by the hypothalamic-pituitary-gonadal axis: The pulsatile secretion of GnRH by the hypothalamus induces pituitary expression of the two gonadotropins FSH and LH, which then stimulate Sertoli and Leydig cells, respectively, therefore regulating steroidogenesis and spermatogenesis. However, a growing body of evidence has recently suggested that other hormones act on the reproductive tract since the early phases of fetal development. Anti-Müllerian hormone and INSL3 are still largely used only for research purposes despite being increasingly recognized as markers of Sertoli and Leydig cells function, respectively.
2019
AMH; INSL3; Müllerian ducts; cryptorchidism; testicular development; testis
01 Pubblicazione su rivista::01a Articolo in rivista
AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know? / Sansone, A; Kliesch, S; Isidori, A M; Schlatt, S. - In: ANDROLOGY. - ISSN 2047-2919. - 7:2(2019), pp. 131-138. [10.1111/andr.12597]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1248679
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