Objective: To report the effect of long-term treatment with the tyrosine kinase inhibitor imatinib started before the onset of puberty on semen parameters, bone mineral density, and hormone values. Design: Case report. Setting: University hospital. Patient(s): An 18-year-old man given treatment with imatinib for chronic myeloid leukemia. Intervention(s): Clinical, biochemical and dual-energy X-ray absorptiometry evaluations. Main Outcome Measure(s): Semen analysis, serum levels of gonadotropins, inhibin-B, and testosterone, bone mineral density, markers of skeletal homeostasis. Result(s): Semen analyses showed severe oligozoospermia after long-term administration of imatinib started before puberty. The inhibin-B/FSH ratio was reduced. A low bone mineral density for chronologic age was observed. Conclusion(s): This case study documents the potential risk of an impairment of semen parameters in patients undergoing a treatment with tyrosine kinase inhibitors before the complete maturation of the testis. (Fertil Steril (R) 2011;95:1120.e15-e17. (c) 2011 by American Society for Reproductive Medicine.)

Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty / Mariani, Stefania; Basciani, Sabrina; Andrea, Fabbri; Agati, Luciano; Ulisse, Salvatore; Lubrano, Carla; Spera, Giovanni; Gnessi, Lucio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 95:3(2011), pp. 1120.e15-1120.e17. [10.1016/j.fertnstert.2010.08.060]

Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty

Stefania Mariani;BASCIANI, Sabrina;AGATI, Luciano;ULISSE, SALVATORE;LUBRANO, Carla;SPERA, Giovanni;GNESSI, Lucio
2011

Abstract

Objective: To report the effect of long-term treatment with the tyrosine kinase inhibitor imatinib started before the onset of puberty on semen parameters, bone mineral density, and hormone values. Design: Case report. Setting: University hospital. Patient(s): An 18-year-old man given treatment with imatinib for chronic myeloid leukemia. Intervention(s): Clinical, biochemical and dual-energy X-ray absorptiometry evaluations. Main Outcome Measure(s): Semen analysis, serum levels of gonadotropins, inhibin-B, and testosterone, bone mineral density, markers of skeletal homeostasis. Result(s): Semen analyses showed severe oligozoospermia after long-term administration of imatinib started before puberty. The inhibin-B/FSH ratio was reduced. A low bone mineral density for chronologic age was observed. Conclusion(s): This case study documents the potential risk of an impairment of semen parameters in patients undergoing a treatment with tyrosine kinase inhibitors before the complete maturation of the testis. (Fertil Steril (R) 2011;95:1120.e15-e17. (c) 2011 by American Society for Reproductive Medicine.)
2011
imatinib; chronic myeloid leukemia; oligozoospermia
01 Pubblicazione su rivista::01a Articolo in rivista
Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty / Mariani, Stefania; Basciani, Sabrina; Andrea, Fabbri; Agati, Luciano; Ulisse, Salvatore; Lubrano, Carla; Spera, Giovanni; Gnessi, Lucio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 95:3(2011), pp. 1120.e15-1120.e17. [10.1016/j.fertnstert.2010.08.060]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/124484
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