The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS.

Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort / Bellur, Shubha S; Roberts, Ian S D; Troyanov, Stéphan; Royal, Virginie; Coppo, Rosanna; Cook, H Terence; Cattran, Daniel; Arce Terroba, Yolanda; Asunis, Anna Maria; Bajema, Ingeborg; Bertoni, Elisabetta; Bruijn, Jan A; Cannata-Ortiz, Pablo; Casartelli, Donatella; Maria Di Palma, Anna; Ferrario, Franco; Fortunato, Mirella; Furci, Luciana; Gakiopoulou, Hariklia; Galesic Ljubanovic, Danica; Giannakakis, Konstantinos; Gomà, Montserrat; Gröne, Hermann-Josef; Gutiérrez, Eduardo M; Asma Haider, S; Honsova, Eva; Ioachim, Elli; Karkoszka, Henryk; Kipgen, David; Maldyk, Jagoda; Mazzucco, Gianna; Orhan, Diclehan; Ozluk, Yasemin; Pantzaki, Afroditi; Perkowska-Ptasinska, Agnieszka; Riispere, Zivili; Soderberg, Magnus P; Steenbergen, Eric; Stoppacciaro, Antonella; Sundelin Von Feilitzen, Birgitta; Tardanico, Regina. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - (2018), pp. 1-10. [10.1093/ndt/gfy337]

Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort

Giannakakis, Konstantinos;Stoppacciaro, Antonella;
2018

Abstract

The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS.
2018
IgA nephropathy; immunosuppression; kidney biopsy; Oxford classification, proteinuria
01 Pubblicazione su rivista::01a Articolo in rivista
Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort / Bellur, Shubha S; Roberts, Ian S D; Troyanov, Stéphan; Royal, Virginie; Coppo, Rosanna; Cook, H Terence; Cattran, Daniel; Arce Terroba, Yolanda; Asunis, Anna Maria; Bajema, Ingeborg; Bertoni, Elisabetta; Bruijn, Jan A; Cannata-Ortiz, Pablo; Casartelli, Donatella; Maria Di Palma, Anna; Ferrario, Franco; Fortunato, Mirella; Furci, Luciana; Gakiopoulou, Hariklia; Galesic Ljubanovic, Danica; Giannakakis, Konstantinos; Gomà, Montserrat; Gröne, Hermann-Josef; Gutiérrez, Eduardo M; Asma Haider, S; Honsova, Eva; Ioachim, Elli; Karkoszka, Henryk; Kipgen, David; Maldyk, Jagoda; Mazzucco, Gianna; Orhan, Diclehan; Ozluk, Yasemin; Pantzaki, Afroditi; Perkowska-Ptasinska, Agnieszka; Riispere, Zivili; Soderberg, Magnus P; Steenbergen, Eric; Stoppacciaro, Antonella; Sundelin Von Feilitzen, Birgitta; Tardanico, Regina. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - (2018), pp. 1-10. [10.1093/ndt/gfy337]
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