Background: Hypovitaminosis D is prevalent in inflammatory bowel disease (IBD) and may be associated with disease activity. Aim: This study evaluated vitamin D (VitD) status in an Italian cohort of IBD patients, not taking VitD supplementation. We investigated risk factors for VitD deficiency and its correlation with disease activity. Methods: VitD levels were measured in 300 consecutive outpatients (42% with Crohn's Disease (CD) and 58% with ulcerative colitis (UC), 56% male) from a tertiary referral center. Data from the IBD cohort were compared with those of 234 healthy controls, matched by sex, age, and the month in which VitD levels were measured. Results: The mean VitD level in IBD patients was significantly lower than in controls (18.9 ng/ml vs. 25 ng/ml, p < 0.001) when accounting for gender, age, and season. VitD deficiency was present in 62% of IBD patients. Risk factors for deficiency were: age <40 and ≥60 years, winter, previous surgery, C-reactive protein (CRP) ≥0.5 mg/dl, and erythrocyte sedimentation rate ≥20 mm/h. In multivariate analysis, VitD levels were negatively influenced by disease location and CRP in UC. Conclusions: Although VitD deficiency was more prevalent than expected in healthy controls living in a Mediterranean country not at high risk of hypovitaminosis D, it was more common and severe in IBD patients. This study also found an association between VitD status and disease activity

Factors affecting vitamin D deficiency in active inflammatory bowel diseases / Burrelli Scotti, Giorgia; Afferri, Maria Teresa; De Carolis, Aurora; Vaiarello, Valentina; Fassino, Valeria; Ferrone, Federica; Minisola, Salvatore; Nieddu, Luciano; Vernia, Piero. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - (2018). [10.1016/j.dld.2018.11.036]

Factors affecting vitamin D deficiency in active inflammatory bowel diseases

Afferri, Maria Teresa;De Carolis, Aurora;Vaiarello, Valentina;Fassino, Valeria;Ferrone, Federica;Minisola, Salvatore
Membro del Collaboration Group
;
Nieddu, Luciano;Vernia, Piero
2018

Abstract

Background: Hypovitaminosis D is prevalent in inflammatory bowel disease (IBD) and may be associated with disease activity. Aim: This study evaluated vitamin D (VitD) status in an Italian cohort of IBD patients, not taking VitD supplementation. We investigated risk factors for VitD deficiency and its correlation with disease activity. Methods: VitD levels were measured in 300 consecutive outpatients (42% with Crohn's Disease (CD) and 58% with ulcerative colitis (UC), 56% male) from a tertiary referral center. Data from the IBD cohort were compared with those of 234 healthy controls, matched by sex, age, and the month in which VitD levels were measured. Results: The mean VitD level in IBD patients was significantly lower than in controls (18.9 ng/ml vs. 25 ng/ml, p < 0.001) when accounting for gender, age, and season. VitD deficiency was present in 62% of IBD patients. Risk factors for deficiency were: age <40 and ≥60 years, winter, previous surgery, C-reactive protein (CRP) ≥0.5 mg/dl, and erythrocyte sedimentation rate ≥20 mm/h. In multivariate analysis, VitD levels were negatively influenced by disease location and CRP in UC. Conclusions: Although VitD deficiency was more prevalent than expected in healthy controls living in a Mediterranean country not at high risk of hypovitaminosis D, it was more common and severe in IBD patients. This study also found an association between VitD status and disease activity
2018
Crohn's Disease; Inflammatory bowel disease; Ulcerative colitis; Vitamin D; Hepatology; Gastroenterology
01 Pubblicazione su rivista::01a Articolo in rivista
Factors affecting vitamin D deficiency in active inflammatory bowel diseases / Burrelli Scotti, Giorgia; Afferri, Maria Teresa; De Carolis, Aurora; Vaiarello, Valentina; Fassino, Valeria; Ferrone, Federica; Minisola, Salvatore; Nieddu, Luciano; Vernia, Piero. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - (2018). [10.1016/j.dld.2018.11.036]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1237659
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