BACKGROUND/AIM: Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpose of this study was to examine endogastric cytopathology and hemoglobin level count as new features, potentially useful for GC patients after NAC. PATIENTS AND METHODS: Between April 2012 and October 2018, 21 of 116 patients with resectable GC received NAC and were investigated for the presence of free-floating malignant cells in their gastric lavage (yGL1) and the development of hypohemoglobinia (yAnemia). RESULTS: yGL1 and yAnemia were found in 11 and 12 patients, respectively. yGL1 correlated with the traditional parameters of tumor regression (p=0.0424). Both yGL1 and yAnemia were found to be independent predictive factors of overall and progression-free survival (p≤0.0364). CONCLUSION: In the light of our results, the yGL1 and yAnemia appear two promising, simple and interesting clinicopathological features which should always be examined for better clarifying GC patients' response to NAC.

Gastric lavage malignant cells (yGL) and hypohemoglobinemia (yAnemia) as new systems of tumor regression grading and prognostic prediction for gastric cancer after neoadjuvant treatment / Virgilio, Edoardo; Giarnieri, Enrico; Giovagnoli, Maria Rosaria; Montagnini, Monica; Proietti, Antonella; D'Urso, Rosaria; Fegiz, Alessandra; Mercantini, Paolo; Balducci, Genoveffa; Cavallini, Marco. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 39:2(2019), pp. 1019-1027. [10.21873/anticanres.13208]

Gastric lavage malignant cells (yGL) and hypohemoglobinemia (yAnemia) as new systems of tumor regression grading and prognostic prediction for gastric cancer after neoadjuvant treatment

Virgilio, Edoardo
Primo
;
Giarnieri, Enrico
Secondo
;
Giovagnoli, Maria Rosaria;Montagnini, Monica;Proietti, Antonella;D'Urso, Rosaria;Fegiz, Alessandra;Mercantini, Paolo;Balducci, Genoveffa
Penultimo
;
Cavallini, Marco
Ultimo
2019

Abstract

BACKGROUND/AIM: Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpose of this study was to examine endogastric cytopathology and hemoglobin level count as new features, potentially useful for GC patients after NAC. PATIENTS AND METHODS: Between April 2012 and October 2018, 21 of 116 patients with resectable GC received NAC and were investigated for the presence of free-floating malignant cells in their gastric lavage (yGL1) and the development of hypohemoglobinia (yAnemia). RESULTS: yGL1 and yAnemia were found in 11 and 12 patients, respectively. yGL1 correlated with the traditional parameters of tumor regression (p=0.0424). Both yGL1 and yAnemia were found to be independent predictive factors of overall and progression-free survival (p≤0.0364). CONCLUSION: In the light of our results, the yGL1 and yAnemia appear two promising, simple and interesting clinicopathological features which should always be examined for better clarifying GC patients' response to NAC.
2019
neoadjuvant chemotherapy; cytopathology; gastric cancer; gastric lavage; neoadjuvant radiotherapy; neoadjuvant treatment; oncology
01 Pubblicazione su rivista::01a Articolo in rivista
Gastric lavage malignant cells (yGL) and hypohemoglobinemia (yAnemia) as new systems of tumor regression grading and prognostic prediction for gastric cancer after neoadjuvant treatment / Virgilio, Edoardo; Giarnieri, Enrico; Giovagnoli, Maria Rosaria; Montagnini, Monica; Proietti, Antonella; D'Urso, Rosaria; Fegiz, Alessandra; Mercantini, Paolo; Balducci, Genoveffa; Cavallini, Marco. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 39:2(2019), pp. 1019-1027. [10.21873/anticanres.13208]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1232193
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