Objective To assess the effects of maternal and intra-amniotic hyperimmunoglobulin (HIG) infusions among cytomegalovirus (CMV) infected fetuses with ultrasound abnormalities following a primary CMV infection. Patients and Methods The subjects were fetuses with CMV-associated cerebral and other ultrasound abnormalities. Three mothers were treated with HIG infusions during pregnancy and two were untreated. Fetal ventricle size, organ echodensity and placental thickness were measured by ultrasound before and after HIG infusions. The children were evaluated between 3 and 7 years of age. Results The ventriculomegaly of all three fetuses of HIG-treated mothers regressed and the ascites, hepatic echodensities, periventricular echodensities, and intestinal echodensities disappeared. Their sensorial, mental and motor development was normal at 4, 4.7, and 7 years of age. In contrast, both infants born of untreated mothers had signs and symptoms of severe CMV cerebropathy. Conclusion The outcomes of the infants born to HIG-treated mothers support the efficacy of HIG as a treatment for CMV-infected fetuses with ultrasound cerebral abnormalities. Copyright (C) 2008 John Wiley & Sons, Ltd.

Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy / Giovanni, Nigro; LA TORRE, Renato; Henny, Pentimalli; Paola, Taverna; Mario, Lituania; Begona Martinez De, Tejada; P., Adler Stuart. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - 28:6(2008), pp. 512-517. [10.1002/pd.2013]

Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy

LA TORRE, Renato;
2008

Abstract

Objective To assess the effects of maternal and intra-amniotic hyperimmunoglobulin (HIG) infusions among cytomegalovirus (CMV) infected fetuses with ultrasound abnormalities following a primary CMV infection. Patients and Methods The subjects were fetuses with CMV-associated cerebral and other ultrasound abnormalities. Three mothers were treated with HIG infusions during pregnancy and two were untreated. Fetal ventricle size, organ echodensity and placental thickness were measured by ultrasound before and after HIG infusions. The children were evaluated between 3 and 7 years of age. Results The ventriculomegaly of all three fetuses of HIG-treated mothers regressed and the ascites, hepatic echodensities, periventricular echodensities, and intestinal echodensities disappeared. Their sensorial, mental and motor development was normal at 4, 4.7, and 7 years of age. In contrast, both infants born of untreated mothers had signs and symptoms of severe CMV cerebropathy. Conclusion The outcomes of the infants born to HIG-treated mothers support the efficacy of HIG as a treatment for CMV-infected fetuses with ultrasound cerebral abnormalities. Copyright (C) 2008 John Wiley & Sons, Ltd.
2008
ascites; cmv-specific immunoglobulins; congenital cytomegalovirus infection; hepatic and intestinal echodensities; periventricular; ventriculomegaly
01 Pubblicazione su rivista::01a Articolo in rivista
Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy / Giovanni, Nigro; LA TORRE, Renato; Henny, Pentimalli; Paola, Taverna; Mario, Lituania; Begona Martinez De, Tejada; P., Adler Stuart. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - 28:6(2008), pp. 512-517. [10.1002/pd.2013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/122581
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