Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood. The prototypical clinical phenotype of CBD is corticobasal syndrome (CBS). Important insights into the pathophysiological mechanisms underlying motor and higher cortical symptoms in CBS have been gained by using advanced neuroimaging and neurophysiological techniques. Structural and functional neuroimaging studies often showed asymmetric cortical and subcortical abnormalities, mainly involving perirolandic and parietal regions and basal ganglia structures. Neurophysiological investigations including electroencephalography and somatosensory evoked potentials provided useful information on the origin of myoclonus and on cortical sensory loss. Transcranial magnetic stimulation demonstrated heterogeneous and asymmetric changes in the excitability and plasticity of primary motor cortex and abnormal hemispheric connectivity. Neuroimaging and neurophysiological abnormalities in multiple brain areas reflect the asymmetric neurodegeneration, leading to the asymmetric motor and higher cortical symptoms in CBS. This article is protected by copyright. All rights reserved.

Corticobasal syndrome: neuroimaging and neurophysiological advances / Di Stasio, Flavio; Suppa, Antonio; Marsili, Luca; Upadhyay, Neeraj; Asci, Francesco; Bologna, Matteo; Colosimo, Carlo; Fabbrini, Giovanni; Pantano, Patrizia; Berardelli, Alfredo. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - feb 2019:0(2019). [10.1111/ene.13928]

Corticobasal syndrome: neuroimaging and neurophysiological advances

Suppa, Antonio;Upadhyay, Neeraj;Asci, Francesco;Bologna, Matteo;Colosimo, Carlo;Fabbrini, Giovanni;Pantano, Patrizia;Berardelli, Alfredo
2019

Abstract

Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood. The prototypical clinical phenotype of CBD is corticobasal syndrome (CBS). Important insights into the pathophysiological mechanisms underlying motor and higher cortical symptoms in CBS have been gained by using advanced neuroimaging and neurophysiological techniques. Structural and functional neuroimaging studies often showed asymmetric cortical and subcortical abnormalities, mainly involving perirolandic and parietal regions and basal ganglia structures. Neurophysiological investigations including electroencephalography and somatosensory evoked potentials provided useful information on the origin of myoclonus and on cortical sensory loss. Transcranial magnetic stimulation demonstrated heterogeneous and asymmetric changes in the excitability and plasticity of primary motor cortex and abnormal hemispheric connectivity. Neuroimaging and neurophysiological abnormalities in multiple brain areas reflect the asymmetric neurodegeneration, leading to the asymmetric motor and higher cortical symptoms in CBS. This article is protected by copyright. All rights reserved.
2019
atypical parkinsonism; corticobasal degeneration; corticobasal syndrome; neuroimaging; neurophysiology; theta burst stimulation
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Corticobasal syndrome: neuroimaging and neurophysiological advances / Di Stasio, Flavio; Suppa, Antonio; Marsili, Luca; Upadhyay, Neeraj; Asci, Francesco; Bologna, Matteo; Colosimo, Carlo; Fabbrini, Giovanni; Pantano, Patrizia; Berardelli, Alfredo. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - feb 2019:0(2019). [10.1111/ene.13928]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1225619
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