Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (-54.1%±8.6% at 72 hours and -57.4%±7.6% at discharge) than NT-proBNP concentration (-17.6%±5.4% at 72 hours and -18.6%±5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy. Congest Heart Fail. © 2008 Le Jacq.

Brain natriuretic peptide and n-terminal pro-b-type natriuretic peptide show a different profile in response to acute decompensated heart failure treatment / DI SOMMA, Salvatore; Magrini, L; Tabacco, F; Talucci, V; Marrocco, F; Cardelli, Patrizia; Ferri, Enrico; Pittoni, V.; Marino, Rossella. - In: CONGESTIVE HEART FAILURE. - ISSN 1527-5299. - STAMPA. - 14:5(2008), pp. 245-250. [10.1111/j.1751-7133.2008.00002.x]

Brain natriuretic peptide and n-terminal pro-b-type natriuretic peptide show a different profile in response to acute decompensated heart failure treatment

DI SOMMA, Salvatore;CARDELLI, Patrizia;FERRI, Enrico;MARINO, Rossella
2008

Abstract

Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (-54.1%±8.6% at 72 hours and -57.4%±7.6% at discharge) than NT-proBNP concentration (-17.6%±5.4% at 72 hours and -18.6%±5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy. Congest Heart Fail. © 2008 Le Jacq.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/122532
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