Over the past few decades, abnormalities in sensory functions, such as tactile, proprioceptive and nociceptive processing, have been increasingly recognized in patients with focal dystonias. In this Review, we ask whether sensory system abnormalities are specific to particular types of dystonia, whether a causal link exists between sensory alterations and dystonic motor activity and how mechanisms underlying the sensory abnormalities fit in with the proposed 'network model' of dystonia. We suggest that alterations in the various sensory modalities participate at three different levels in the pathophysiological cascade that leads to dystonia: a background level that predisposes individuals to dystonia, a disease-related level that is evident only when dystonia becomes manifest and a causative level that triggers dystonia. We conclude that it is crucial to study sensory as well as motor pathophysiology to fully understand focal dystonias.

The role of sensory information in the pathophysiology of focal dystonias / Conte, Antonella; Defazio, Giovanni; Hallett, Mark; Fabbrini, Giovanni; Berardelli, Alfredo. - In: NATURE REVIEWS. NEUROLOGY. - ISSN 1759-4758. - 15:4(2019), pp. 224-233. [10.1038/s41582-019-0137-9]

The role of sensory information in the pathophysiology of focal dystonias

Conte, Antonella;DEFAZIO, GIOVANNI;Fabbrini, Giovanni;Berardelli, Alfredo
2019

Abstract

Over the past few decades, abnormalities in sensory functions, such as tactile, proprioceptive and nociceptive processing, have been increasingly recognized in patients with focal dystonias. In this Review, we ask whether sensory system abnormalities are specific to particular types of dystonia, whether a causal link exists between sensory alterations and dystonic motor activity and how mechanisms underlying the sensory abnormalities fit in with the proposed 'network model' of dystonia. We suggest that alterations in the various sensory modalities participate at three different levels in the pathophysiological cascade that leads to dystonia: a background level that predisposes individuals to dystonia, a disease-related level that is evident only when dystonia becomes manifest and a causative level that triggers dystonia. We conclude that it is crucial to study sensory as well as motor pathophysiology to fully understand focal dystonias.
2019
dystonia; sensory abnormalities; pathophysiology
01 Pubblicazione su rivista::01a Articolo in rivista
The role of sensory information in the pathophysiology of focal dystonias / Conte, Antonella; Defazio, Giovanni; Hallett, Mark; Fabbrini, Giovanni; Berardelli, Alfredo. - In: NATURE REVIEWS. NEUROLOGY. - ISSN 1759-4758. - 15:4(2019), pp. 224-233. [10.1038/s41582-019-0137-9]
File allegati a questo prodotto
File Dimensione Formato  
Conte_the-role-of-sensory_2019.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 815.59 kB
Formato Adobe PDF
815.59 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1225299
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 50
social impact