Natural killer (NK) cells are a key component of innate immunity, particularly crucial during the early phase of immune responses against certain viruses, parasites, and microbial pathogens. The role of NK cell during pregnancy has been vividly discussed over the past years and it is now becoming increasingly clear that NK cells control pregnancy maintenance at several levels. In normal pregnancy, it appears that they provide benefit by properly secreting cytokines, chemokines and angiogenic factors rather than functioning as cytotoxic effector cells. However, as they are endowed with all the cytolytic weapons, they promptly become capable of attacking fetal and maternal tissues during infection and inflammation. © 2007 The Authors Journal compilation 2007 Blackwell Munksgaard.

Natural killer (NK) cells from killers to regulators: Distinct features between peripheral blood and decidual NK cells / Santoni, Angela; Zingoni, Alessandra; Cerboni, Cristina; Gismondi, Angela. - In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - ISSN 1046-7408. - STAMPA. - 58:3(2007), pp. 280-288. [10.1111/j.1600-0897.2007.00513.x]

Natural killer (NK) cells from killers to regulators: Distinct features between peripheral blood and decidual NK cells

SANTONI, Angela;ZINGONI, Alessandra;CERBONI, CRISTINA;GISMONDI, Angela
2007

Abstract

Natural killer (NK) cells are a key component of innate immunity, particularly crucial during the early phase of immune responses against certain viruses, parasites, and microbial pathogens. The role of NK cell during pregnancy has been vividly discussed over the past years and it is now becoming increasingly clear that NK cells control pregnancy maintenance at several levels. In normal pregnancy, it appears that they provide benefit by properly secreting cytokines, chemokines and angiogenic factors rather than functioning as cytotoxic effector cells. However, as they are endowed with all the cytolytic weapons, they promptly become capable of attacking fetal and maternal tissues during infection and inflammation. © 2007 The Authors Journal compilation 2007 Blackwell Munksgaard.
2007
angiogenesis; chemokines; cytokines; migration; natural killer cells; uterine nk cells
01 Pubblicazione su rivista::01a Articolo in rivista
Natural killer (NK) cells from killers to regulators: Distinct features between peripheral blood and decidual NK cells / Santoni, Angela; Zingoni, Alessandra; Cerboni, Cristina; Gismondi, Angela. - In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - ISSN 1046-7408. - STAMPA. - 58:3(2007), pp. 280-288. [10.1111/j.1600-0897.2007.00513.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/122514
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