Background: Dental caries is a recognized worldwide public health problem. Despite being one of the most efective strategies against dental caries, the excessive use of fuorine may result in a potential risk of developing dental fuorosis especially in children under age of six. The purpose of this work is to analyze a fuorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties. Results: The study was performed in vitro and in vivo, comparing the hydroxyapatite toothpaste with two others toothpaste containing diferent fuorine concentrations. The coating efect of the micro-structured Hydroxyapatite nanoparticles reintegrates the enamel with a biomimetic flm reproducing the structure and the morphology of the biologic Hydroxyapatite of the enamel. As demonstrated, the coating is due to the deposit of a new layer of apatite, which presents fewer particles than the natural enamel, not based on the chemical—physical changes occurring in fuorinated toothpastes. Moreover, it shows resistance to brushing as a consequence of chemical bonds between the synthetic and natural crystals of the enamel. Conclusions: The use of Biomimetic Hydroxyapatite toothpastes has proven to be a valuable prevention measure against dental caries in primary dentition since it prevents the risk of fuorosis.

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste / Bossù, Maurizio; Saccucci, Matteo; Salucci, Alessandro; Di Giorgio, Gianni; Bruni, Erika; Uccelletti, Daniela; Sarto, Maria Sabrina; Familiari, Giuseppe; Relucenti, Michela; Polimeni, Antonella. - In: JOURNAL OF NANOBIOTECHNOLOGY. - ISSN 1477-3155. - 17:1(2019), pp. 1-13. [10.1186/s12951-019-0454-6]

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste

Bossù, Maurizio
Primo
;
Saccucci, Matteo
Secondo
;
Salucci, Alessandro;Di Giorgio, Gianni;Bruni, Erika;Uccelletti, Daniela;Sarto, Maria Sabrina;Familiari, Giuseppe;Relucenti, Michela
Penultimo
;
Polimeni, Antonella
Ultimo
2019

Abstract

Background: Dental caries is a recognized worldwide public health problem. Despite being one of the most efective strategies against dental caries, the excessive use of fuorine may result in a potential risk of developing dental fuorosis especially in children under age of six. The purpose of this work is to analyze a fuorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties. Results: The study was performed in vitro and in vivo, comparing the hydroxyapatite toothpaste with two others toothpaste containing diferent fuorine concentrations. The coating efect of the micro-structured Hydroxyapatite nanoparticles reintegrates the enamel with a biomimetic flm reproducing the structure and the morphology of the biologic Hydroxyapatite of the enamel. As demonstrated, the coating is due to the deposit of a new layer of apatite, which presents fewer particles than the natural enamel, not based on the chemical—physical changes occurring in fuorinated toothpastes. Moreover, it shows resistance to brushing as a consequence of chemical bonds between the synthetic and natural crystals of the enamel. Conclusions: The use of Biomimetic Hydroxyapatite toothpastes has proven to be a valuable prevention measure against dental caries in primary dentition since it prevents the risk of fuorosis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1220322
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