Our study concerns the expression and the regulation of adhesion and activation receptors on human NK cells. In particular we provide evidence on: a) the expression on fresh human NK cells of VLA-4, VLA-5 and VLA-6, extracellular matrix (ECM) receptors of integrin family capable of mediating their adhesion to FN and LM; b) the role of PKC on the regulation of CD 16, a differentiation antigen associated with Fc-gamma-R type III expressed by all NK cells, which mediate ADCC activity and trigger lymphokine production.
Adhesion and activation molecules expressed by human natural killer cells / Santoni, Angela; Gismondi, Angela; Paolini, Rossella; Morrone, Stefania; Mainiero, Fabrizio; Santoni, G; Piccoli, Mario; Frati, Luigi. - In: CYTOTECHNOLOGY. - ISSN 0920-9069. - STAMPA. - 5:(1991), pp. 117-121. [10.1007/BF00736826]
Adhesion and activation molecules expressed by human natural killer cells
SANTONI, Angela;GISMONDI, Angela;PAOLINI, Rossella;MORRONE, Stefania;MAINIERO, Fabrizio;PICCOLI, Mario;FRATI, Luigi
1991
Abstract
Our study concerns the expression and the regulation of adhesion and activation receptors on human NK cells. In particular we provide evidence on: a) the expression on fresh human NK cells of VLA-4, VLA-5 and VLA-6, extracellular matrix (ECM) receptors of integrin family capable of mediating their adhesion to FN and LM; b) the role of PKC on the regulation of CD 16, a differentiation antigen associated with Fc-gamma-R type III expressed by all NK cells, which mediate ADCC activity and trigger lymphokine production.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
