PURPOSE: To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to tumor grading and to assess their reliability in predicting pathological complete response (pCR) before neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS: Forty patients (24 male; mean age, 67.3 ± 8.1 years) with histologically proven LARC who had undergone 3-Tesla DCE-MRI before (MRI_1) and after CRT (MRI_2) between August 2015 and February 2016 were included in this retrospective study. DCE-MRI parameters at MRI_1 and MRI_2 were extracted by two board certified radiologists in consensus reading with Olea Sphere 2.3 software using the extended Tofts model. Based on DCE-MRI results, patients were divided in complete responders (CR) and non-complete responders (nCR) and the perfusion parameters were correlated to tumor grading and pCR. RESULTS: Wash-out and Kep at MRI_1 showed significant correlation with LARC grading (P = 0.004 and 0.01, respectively). Ve showed a significant increase between MRI_1 (0.47 ± 0.27) and MRI_2 (0.63 ± 0.23; P = 0.007). Ktrans measured at MRI_1 was significantly higher in CR (0.66 ± 0.48) compared to nCR (0.53 ± 0.34, P = 0.02). CONCLUSION: Wash-out and Kep measured before CRT correlate with LARC grading. Ve changes during CRT, while Ktrans measured before CRT may predict the response to therapy. Therefore, DCE-MRI parameters can predict tumor aggressiveness and CRT efficacy, playing a role as imaging biomarkers in patients with LARC.

Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment / Ciolina, Maria; Caruso, Damiano; De Santis, Domenico; Zerunian, Marta; Rengo, Marco; Alfieri, Norma; Musio, Daniela; De Felice, Francesca; Ciardi, Antonio; Tombolini, Vincenzo; Laghi, Andrea. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 124:5(2019), pp. 331-338. [10.1007/s11547-018-0978-0]

Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment

Ciolina, Maria
Primo
;
Caruso, Damiano
Secondo
;
De Santis, Domenico;Zerunian, Marta;Rengo, Marco;Alfieri, Norma;De Felice, Francesca;Ciardi, Antonio;Tombolini, Vincenzo
Penultimo
;
Laghi, Andrea
Ultimo
2019

Abstract

PURPOSE: To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to tumor grading and to assess their reliability in predicting pathological complete response (pCR) before neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS: Forty patients (24 male; mean age, 67.3 ± 8.1 years) with histologically proven LARC who had undergone 3-Tesla DCE-MRI before (MRI_1) and after CRT (MRI_2) between August 2015 and February 2016 were included in this retrospective study. DCE-MRI parameters at MRI_1 and MRI_2 were extracted by two board certified radiologists in consensus reading with Olea Sphere 2.3 software using the extended Tofts model. Based on DCE-MRI results, patients were divided in complete responders (CR) and non-complete responders (nCR) and the perfusion parameters were correlated to tumor grading and pCR. RESULTS: Wash-out and Kep at MRI_1 showed significant correlation with LARC grading (P = 0.004 and 0.01, respectively). Ve showed a significant increase between MRI_1 (0.47 ± 0.27) and MRI_2 (0.63 ± 0.23; P = 0.007). Ktrans measured at MRI_1 was significantly higher in CR (0.66 ± 0.48) compared to nCR (0.53 ± 0.34, P = 0.02). CONCLUSION: Wash-out and Kep measured before CRT correlate with LARC grading. Ve changes during CRT, while Ktrans measured before CRT may predict the response to therapy. Therefore, DCE-MRI parameters can predict tumor aggressiveness and CRT efficacy, playing a role as imaging biomarkers in patients with LARC.
2019
imaging biomarkers; locally advanced rectal cancer; magnetic resonance imaging; neoadjuvant therapy; patient outcome
01 Pubblicazione su rivista::01a Articolo in rivista
Dynamic contrast-enhanced magnetic resonance imaging in locally advanced rectal cancer: role of perfusion parameters in the assessment of response to treatment / Ciolina, Maria; Caruso, Damiano; De Santis, Domenico; Zerunian, Marta; Rengo, Marco; Alfieri, Norma; Musio, Daniela; De Felice, Francesca; Ciardi, Antonio; Tombolini, Vincenzo; Laghi, Andrea. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 124:5(2019), pp. 331-338. [10.1007/s11547-018-0978-0]
File allegati a questo prodotto
File Dimensione Formato  
Ciolina_Dynamic_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 978.63 kB
Formato Adobe PDF
978.63 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1211937
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 33
social impact