Effects of aspirin, ace-inhibitors/sartans and statins on neoplastic and pre- neoplastic lesions of the pancreas

Aspirin, ace inhibitors/sartans and statins are largely used in primary or secondary cardiovascular prophylaxis. Such drugs have been suggested to play also a role in inhibiting cancer initiation and progression in several clinical and preclinical humoral models. So far, they role in the initiation and progression of pancreatic neoplastic and preneoplastic lesions has been poorly investigated. The aim of the current thesis is to evaluate the effect of such drugs on the progression of pancreatic BD-IPMNs, on the recurrence of cancer after surgery for IPMNs, as well as to evaluate a possible influence in modulating the incidence of pancreas cancer and neuroendocrine tumors.