There is evidence that both early experience and genetic variation play a role in influencing sensitivity to social rejection. In this study, we aimed at ascertaining if the A118G polymorphism of the k-opioid receptor gene (OPRM1) moderates the impact of early maternal care on fearful attachment, a personality trait strongly related to rejection sensitivity. In 112 psychiatric patients, early maternal care and fearful attachment were measured using the Parental Bonding Inventory and the Relationship Questionnaire (RQ), respectively. The pattern emerging from the RQ data was a crossover interaction between genotype and maternal caregiving. Participants expressing the minor 118 G allele had similar and relatively high scores on fearful attachment regardless of the quality of maternal care. By contrast, early experience made a major difference for participants carrying the A/A genotype. Those who recalled higher levels of maternal care reported the lowest levels of fearful attachment whereas those who recalled lower levels of maternal care scored highest on fearful attachment. Our data fit well with the differential susceptibility model which stipulates that plasticity genes would make some individuals more responsive than others to the negative consequences of adversity and to the benefits of environmental support and enrichment.

Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment / Troisi, A; Frazzetto, G; Carola, V; Di Lorenzo, G; Coviello, M; Siracusano, A; Gross, C.. - In: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE. - ISSN 1749-5024. - 7:5(2012), pp. 542-547. [10.1093/scan/nsr037]

Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment

Carola V
;
2012

Abstract

There is evidence that both early experience and genetic variation play a role in influencing sensitivity to social rejection. In this study, we aimed at ascertaining if the A118G polymorphism of the k-opioid receptor gene (OPRM1) moderates the impact of early maternal care on fearful attachment, a personality trait strongly related to rejection sensitivity. In 112 psychiatric patients, early maternal care and fearful attachment were measured using the Parental Bonding Inventory and the Relationship Questionnaire (RQ), respectively. The pattern emerging from the RQ data was a crossover interaction between genotype and maternal caregiving. Participants expressing the minor 118 G allele had similar and relatively high scores on fearful attachment regardless of the quality of maternal care. By contrast, early experience made a major difference for participants carrying the A/A genotype. Those who recalled higher levels of maternal care reported the lowest levels of fearful attachment whereas those who recalled lower levels of maternal care scored highest on fearful attachment. Our data fit well with the differential susceptibility model which stipulates that plasticity genes would make some individuals more responsive than others to the negative consequences of adversity and to the benefits of environmental support and enrichment.
2012
OPRM1 gene; maternal care; fearful attachment; rejection sensitivity
01 Pubblicazione su rivista::01a Articolo in rivista
Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment / Troisi, A; Frazzetto, G; Carola, V; Di Lorenzo, G; Coviello, M; Siracusano, A; Gross, C.. - In: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE. - ISSN 1749-5024. - 7:5(2012), pp. 542-547. [10.1093/scan/nsr037]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1209980
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