Changes of corneal thickness and endothelial ultrastructure of rabbit eyes after radial keratotomy as well as effects of prednisolone and bendazac-lysine on keratectomized corneas were studied. The corneal thickness increased after keratotomy and the maximum values of control eyes were measured on the seventh day postoperatively; they returned to normal after 2 months. Swelling of mitochondria, disappearance of cristae, increased synthetic activity, and elaboration of cell junction were found with electron microscope. We conclude that direct trauma or postoperative inflammation plays a minor role in the pathogenesis of endothelial alterations, while elaboration of free radicals during normal regenerating processes may be a principal cause of endothelial changes. Prednisolone treatment was ineffective in preventing the development of corneal edema and endothelial alterations. Bendazac-lysine treatment decreased both corneal edema and endothelial changes.
CORNEAL ENDOTHELIAL CHANGES IN EXPERIMENTAL RADIAL KERATOTOMY AND THEYR TREATMENT WITH BENDAZAC-LYSINE / J. M., Feher; Librando, Aloisa; S., Spizzirri; G., DE FEO; E., Graziano. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - STAMPA. - 52:1(1992), pp. 53-63. [10.1016/S0011-393X(05)80436-9]
CORNEAL ENDOTHELIAL CHANGES IN EXPERIMENTAL RADIAL KERATOTOMY AND THEYR TREATMENT WITH BENDAZAC-LYSINE
LIBRANDO, Aloisa;
1992
Abstract
Changes of corneal thickness and endothelial ultrastructure of rabbit eyes after radial keratotomy as well as effects of prednisolone and bendazac-lysine on keratectomized corneas were studied. The corneal thickness increased after keratotomy and the maximum values of control eyes were measured on the seventh day postoperatively; they returned to normal after 2 months. Swelling of mitochondria, disappearance of cristae, increased synthetic activity, and elaboration of cell junction were found with electron microscope. We conclude that direct trauma or postoperative inflammation plays a minor role in the pathogenesis of endothelial alterations, while elaboration of free radicals during normal regenerating processes may be a principal cause of endothelial changes. Prednisolone treatment was ineffective in preventing the development of corneal edema and endothelial alterations. Bendazac-lysine treatment decreased both corneal edema and endothelial changes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
