Obesity-related disease complications reduce life quality and expectancy and increase health-care costs. Some studies have suggested that obesity not always entails metabolic abnormalities and increased risk of cardiometabolic complications. Because of the lack of universally accepted criteria to identify metabolically healthy obesity (MHO), its prevalence varies widely among studies. Moreover, the prognostic value of MHO is hotly debated, mainly because it likely shifts gradually towards metabolically unhealthy obesity (MUO). In this review, we outline the differential factors contributing to the metabolic heterogeneity of obesity by discussing the behavioral, genetic, phenotypical, and biological aspects associated with each of the two metabolic phenotypes (MHO and MUO) of obesity and their clinical implications. Particular emphasis will be laid on the role of adipose tissue biology and function, including genetic determinants of body fat distribution, depot-specific fat metabolism, adipose tissue plasticity and, particularly, adipogenesis. Finally, the emerging role of gut microbiota in obesity and adipose tissue dysfunction as well as the search for novel biomarkers for the obesity-related metabolic traits and associated diseases will be briefly presented. A better understanding of the main determinants of a healthy metabolic status in obesity would allow promotion of this favorable condition by targeting the relevant pathways.

Metabolically healthy versus metabolically unhealthy obesity / Iacobini, Carla; Pugliese, Giuseppe; Blasetti Fantauzzi, Claudia; Federici, Massimo; Menini, Stefano. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 92:(2019), pp. 51-60. [10.1016/j.metabol.2018.11.009]

Metabolically healthy versus metabolically unhealthy obesity

Iacobini, Carla
Co-primo
;
Pugliese, Giuseppe
Co-primo
;
Blasetti Fantauzzi, Claudia;Menini, Stefano
Ultimo
2019

Abstract

Obesity-related disease complications reduce life quality and expectancy and increase health-care costs. Some studies have suggested that obesity not always entails metabolic abnormalities and increased risk of cardiometabolic complications. Because of the lack of universally accepted criteria to identify metabolically healthy obesity (MHO), its prevalence varies widely among studies. Moreover, the prognostic value of MHO is hotly debated, mainly because it likely shifts gradually towards metabolically unhealthy obesity (MUO). In this review, we outline the differential factors contributing to the metabolic heterogeneity of obesity by discussing the behavioral, genetic, phenotypical, and biological aspects associated with each of the two metabolic phenotypes (MHO and MUO) of obesity and their clinical implications. Particular emphasis will be laid on the role of adipose tissue biology and function, including genetic determinants of body fat distribution, depot-specific fat metabolism, adipose tissue plasticity and, particularly, adipogenesis. Finally, the emerging role of gut microbiota in obesity and adipose tissue dysfunction as well as the search for novel biomarkers for the obesity-related metabolic traits and associated diseases will be briefly presented. A better understanding of the main determinants of a healthy metabolic status in obesity would allow promotion of this favorable condition by targeting the relevant pathways.
2019
adipogenesis; adiposopathy; cardiovascular disease; gut microbiota; metabolically healthy and unhealthy obesity; type 2 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Metabolically healthy versus metabolically unhealthy obesity / Iacobini, Carla; Pugliese, Giuseppe; Blasetti Fantauzzi, Claudia; Federici, Massimo; Menini, Stefano. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 92:(2019), pp. 51-60. [10.1016/j.metabol.2018.11.009]
File allegati a questo prodotto
File Dimensione Formato  
Iacobini_Metabolically_2019.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.91 MB
Formato Adobe PDF
1.91 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1203340
Citazioni
  • ???jsp.display-item.citation.pmc??? 94
  • Scopus 271
  • ???jsp.display-item.citation.isi??? 250
social impact