Background: It is generally accepted that the efficacy with an intragastric balloon decreases after the first 4 months of treatment. Aim of this study is to evaluate if the association of a very low-calorie ketogenic diet (VLCKD) can improve the results in terms of weight loss parameters and co-morbidities, as compared to usually prescribed low-calorie diet (LCD). Methods: For the present study (January 2016–June 2017), 80 patients (20 M/60 F, mean age 37.8 ± 6.1 years; excess weight 56 ± 10 kg; mean BMI 37.2 ± 3.8 kg/m2) underwent Orbera positioning. After 4 months, they were randomized into two groups according to the type of treatment: group A (Bioenterics intragastric balloon – Orbera + VLCKD) (n = 40), and group B (Orbera + LCD) (n = 40). Results: All patients completed the study with good adherence to diet therapy treatment allocation. After the 6-month treatment period, at time of Orbera removal, mean weight loss was 19 kg and 12 kg in groups A and B respectively (p < 0.05). Mean BMI was 28.9 ± 2.8 and 31.6 ± 3.1 kg/m2 (p < 0.05), and %EWL was 33.1 ± 3.3 and 21.1 ± 2.9 (p < 0.05) in groups A and B respectively. During the last 2 months in group A, the mean weight loss was 8 kg, while in Group B, the main weight loss was 3 kg (p < 0.001). The VLCKD treatment induced a more significant reduction of major comorbidities related to metabolic syndrome. Conclusions: This study clearly indicates the efficacy of the prescription of very low-calorie ketogenic diet improving the efficacy of intragastric balloon positioning.

Improving weight loss by combination of two temporary antiobesity treatments / Genco, Alfredo; Ienca, Roberta; Ernesti, Ilaria; Maselli, Roberta; Casella, Giovanni; Bresciani, Sabrina; Mariani, Stefania; Soricelli, Emanuele; Baglio, Giovanni; Lorenzo, Michele; Monti, Massimo. - In: OBESITY SURGERY. - ISSN 0960-8923. - 28:12(2018), pp. 3733-3737. [10.1007/s11695-018-3448-9]

Improving weight loss by combination of two temporary antiobesity treatments

Genco, Alfredo;Ienca, Roberta;Ernesti, Ilaria;Maselli, Roberta;Casella, Giovanni
Writing – Review & Editing
;
Mariani, Stefania;Soricelli, Emanuele;Monti, Massimo
2018

Abstract

Background: It is generally accepted that the efficacy with an intragastric balloon decreases after the first 4 months of treatment. Aim of this study is to evaluate if the association of a very low-calorie ketogenic diet (VLCKD) can improve the results in terms of weight loss parameters and co-morbidities, as compared to usually prescribed low-calorie diet (LCD). Methods: For the present study (January 2016–June 2017), 80 patients (20 M/60 F, mean age 37.8 ± 6.1 years; excess weight 56 ± 10 kg; mean BMI 37.2 ± 3.8 kg/m2) underwent Orbera positioning. After 4 months, they were randomized into two groups according to the type of treatment: group A (Bioenterics intragastric balloon – Orbera + VLCKD) (n = 40), and group B (Orbera + LCD) (n = 40). Results: All patients completed the study with good adherence to diet therapy treatment allocation. After the 6-month treatment period, at time of Orbera removal, mean weight loss was 19 kg and 12 kg in groups A and B respectively (p < 0.05). Mean BMI was 28.9 ± 2.8 and 31.6 ± 3.1 kg/m2 (p < 0.05), and %EWL was 33.1 ± 3.3 and 21.1 ± 2.9 (p < 0.05) in groups A and B respectively. During the last 2 months in group A, the mean weight loss was 8 kg, while in Group B, the main weight loss was 3 kg (p < 0.001). The VLCKD treatment induced a more significant reduction of major comorbidities related to metabolic syndrome. Conclusions: This study clearly indicates the efficacy of the prescription of very low-calorie ketogenic diet improving the efficacy of intragastric balloon positioning.
Intragastric balloon; Ketogenic diet; Weight loss; Surgery; Endocrinology, Diabetes and Metabolism; Nutrition and Dietetics
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Improving weight loss by combination of two temporary antiobesity treatments / Genco, Alfredo; Ienca, Roberta; Ernesti, Ilaria; Maselli, Roberta; Casella, Giovanni; Bresciani, Sabrina; Mariani, Stefania; Soricelli, Emanuele; Baglio, Giovanni; Lorenzo, Michele; Monti, Massimo. - In: OBESITY SURGERY. - ISSN 0960-8923. - 28:12(2018), pp. 3733-3737. [10.1007/s11695-018-3448-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1202908
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