The term Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus infections (PANDAS) was coined by Swedo et al. in 1998 to describe a subset of childhood obsessive-compulsive disorders (OCD) and tic disorders triggered by group-A beta-hemolytic Streptococcus pyogenes infection. Like adult OCD, PANDAS is associated with basal ganglia dysfunction. Other putative pathogenetic mechanisms of PANDAS include molecular mimicry and autoimmune-mediated altered neuronal signaling, involving calcium-calmodulin dependent protein (CaM) kinase II activity. Nonetheless the contrasting results from numerous studies provide no consensus on whether PANDAS should be considered as a specific nosological entity or simply a useful research framework. Herein we discuss available data that could provide insight into pathophysiology of adult OCD, or might explain cases of treatment-resistance. We also review the latest research findings on diagnostic and treatment.

What every psychiatrist should know about PANDAS: a review / Moretti, Germana; Pasquini, M; Mandarelli, Gabriele; Tarsitani, Lorenzo; Biondi, Massimo. - In: CLINICAL PRACTICE AND EPIDEMIOLOGY IN MENTAL HEALTH. - ISSN 1745-0179. - 4:(2008), pp. ---. [10.1186/1745-0179-4-13]

What every psychiatrist should know about PANDAS: a review

PASQUINI M;MANDARELLI, GABRIELE;TARSITANI, LORENZO;BIONDI, Massimo
2008

Abstract

The term Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus infections (PANDAS) was coined by Swedo et al. in 1998 to describe a subset of childhood obsessive-compulsive disorders (OCD) and tic disorders triggered by group-A beta-hemolytic Streptococcus pyogenes infection. Like adult OCD, PANDAS is associated with basal ganglia dysfunction. Other putative pathogenetic mechanisms of PANDAS include molecular mimicry and autoimmune-mediated altered neuronal signaling, involving calcium-calmodulin dependent protein (CaM) kinase II activity. Nonetheless the contrasting results from numerous studies provide no consensus on whether PANDAS should be considered as a specific nosological entity or simply a useful research framework. Herein we discuss available data that could provide insight into pathophysiology of adult OCD, or might explain cases of treatment-resistance. We also review the latest research findings on diagnostic and treatment.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
What every psychiatrist should know about PANDAS: a review / Moretti, Germana; Pasquini, M; Mandarelli, Gabriele; Tarsitani, Lorenzo; Biondi, Massimo. - In: CLINICAL PRACTICE AND EPIDEMIOLOGY IN MENTAL HEALTH. - ISSN 1745-0179. - 4:(2008), pp. ---. [10.1186/1745-0179-4-13]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/119906
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