The main goal of this communication is to show the utility of empirical approaches combined with mathematical methods in the research regarding the molecular basis of biological chirality. Preparative results (enantiomeric excesses, e.e.) obtained in asymmetric autocatalysis with (AAC) and without (AES) chiral additive were analyzed. Statistical calculations show, that AES (absolute enantioselective synthesis) experiments yield two independent groups of results with prevalence of the R- or S-enantiomer. These are distributed asymmetrically in a second-order beta distribution. Empirical calculations both on AAC and EAS enable to identify the very low (statistical) e.e.-s amplified by AES. These initial e.e.-s show normal distribution. Possible molecular-level reasons of these results were controlled by quantum chemical MO calculations and compatible mechanism(s) are discussed.

On the track of absolute enantioselective catalysis / Caglioti, Luciano; B., Barabas; F., Faglioni; N., Florini; P., Lazzeretti; M., Maioli; K., Micskei; G., Rabai; F., Taddei; C., Zucchi; G., Palyi. - In: CHIMICA OGGI-CHEMISTRY TODAY. - ISSN 0392-839X. - STAMPA. - 26 (issue 5) (suppl.):(2008), pp. 30-32.

On the track of absolute enantioselective catalysis

CAGLIOTI, Luciano;
2008

Abstract

The main goal of this communication is to show the utility of empirical approaches combined with mathematical methods in the research regarding the molecular basis of biological chirality. Preparative results (enantiomeric excesses, e.e.) obtained in asymmetric autocatalysis with (AAC) and without (AES) chiral additive were analyzed. Statistical calculations show, that AES (absolute enantioselective synthesis) experiments yield two independent groups of results with prevalence of the R- or S-enantiomer. These are distributed asymmetrically in a second-order beta distribution. Empirical calculations both on AAC and EAS enable to identify the very low (statistical) e.e.-s amplified by AES. These initial e.e.-s show normal distribution. Possible molecular-level reasons of these results were controlled by quantum chemical MO calculations and compatible mechanism(s) are discussed.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
On the track of absolute enantioselective catalysis / Caglioti, Luciano; B., Barabas; F., Faglioni; N., Florini; P., Lazzeretti; M., Maioli; K., Micskei; G., Rabai; F., Taddei; C., Zucchi; G., Palyi. - In: CHIMICA OGGI-CHEMISTRY TODAY. - ISSN 0392-839X. - STAMPA. - 26 (issue 5) (suppl.):(2008), pp. 30-32.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/11985
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