Natural-abundance isotopic substitution in isotopically prochiral groups of otherwise achiral molecules can provide stochastically formed enantiomeric excesses which exceed the sensitivity threshold of sensitive asymmetric autocatalytic (Soai-type) reactions. This kind of induction of chirality should be taken into consideration in in vitro model experiments and offer a new kind of entry into primary prebiotic or early biotic enantioselection in the earliest stages of molecular evolution.
Isotope chirality and asymmetric autocatalysis: A possible entry to biological chirality / Béla, Barabas; Caglioti, Luciano; Karoly, Micskei; Claudia, Zucchi; Gyula, Palyi. - In: ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE. - ISSN 0169-6149. - STAMPA. - 38:4(2008), pp. 317-327. [10.1007/s11084-008-9138-1]
Isotope chirality and asymmetric autocatalysis: A possible entry to biological chirality
CAGLIOTI, Luciano;
2008
Abstract
Natural-abundance isotopic substitution in isotopically prochiral groups of otherwise achiral molecules can provide stochastically formed enantiomeric excesses which exceed the sensitivity threshold of sensitive asymmetric autocatalytic (Soai-type) reactions. This kind of induction of chirality should be taken into consideration in in vitro model experiments and offer a new kind of entry into primary prebiotic or early biotic enantioselection in the earliest stages of molecular evolution.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
