New toluidine derivatives are described. Some of them showed interesting activity against Mycobacteria. They led to an optimization of the pharmacophore model previously described by us. The best-fitted conformer of one of the most active compounds (6a) shows all the chemical groups matched to the chemical features of the model.
New derivatives of toluidine: Synthesis, antitubercular activity and pharmacophore hypothesis / Biava, Mariangela; Fioravanti, Rossella; Porretta, Giulio Cesare; D., Deidda; G., Lampis; R., Pompei; A., Tafi; F., Manetti. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 11:1(2002), pp. 50-66.
New derivatives of toluidine: Synthesis, antitubercular activity and pharmacophore hypothesis
BIAVA, Mariangela;FIORAVANTI, Rossella;PORRETTA, Giulio Cesare;
2002
Abstract
New toluidine derivatives are described. Some of them showed interesting activity against Mycobacteria. They led to an optimization of the pharmacophore model previously described by us. The best-fitted conformer of one of the most active compounds (6a) shows all the chemical groups matched to the chemical features of the model.File allegati a questo prodotto
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