Highly active antiretroviral therapy is effective at reducing morbidity and mortality in human immunodeficiency virus(HIV)-infected patients presenting with symptoms of disease progression. a complex metabolic syndrome has been described in patients treated with highly active antiretroviral therapy. this includes atrophy and redistribution of subcutaneous adipose tissue representing a kind of acquired lipodystrophy(LDHIV,lipodystrophy in HIV-infected patients). LDHIV can be associated with metabolic abnormalities such as dyslipidemia, hyperglycemia, and insuline resistance. several HIV protease inhibitors can inhibit preadipocyte differentiation or can promote apoptosis of adipocytes. we describe the case of a patient with typical LDHIV and its associated metabolic alterations.
Lipodystrophy in a HIV infected patient / Rocchietti March, Massimiliano; Proietta, Maria; Trappolini, Massimo; Pisani, Daniela; Grimaldi, Miriam; Pranteda, Guglielmo; Aliberti, Giuseppe. - In: THE ENDOCRINOLOGIST. - ISSN 1051-2144. - STAMPA. - Volume 20, Num.6:(2010), pp. 293-295. [10.1097/TEN.0b013e318204e16c]
Lipodystrophy in a HIV infected patient
Rocchietti March, Massimiliano;Trappolini, Massimo;Pranteda, Guglielmo;Aliberti, Giuseppe
2010
Abstract
Highly active antiretroviral therapy is effective at reducing morbidity and mortality in human immunodeficiency virus(HIV)-infected patients presenting with symptoms of disease progression. a complex metabolic syndrome has been described in patients treated with highly active antiretroviral therapy. this includes atrophy and redistribution of subcutaneous adipose tissue representing a kind of acquired lipodystrophy(LDHIV,lipodystrophy in HIV-infected patients). LDHIV can be associated with metabolic abnormalities such as dyslipidemia, hyperglycemia, and insuline resistance. several HIV protease inhibitors can inhibit preadipocyte differentiation or can promote apoptosis of adipocytes. we describe the case of a patient with typical LDHIV and its associated metabolic alterations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.