The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p ≤ 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p ≤ 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease / B., Bocca; G., Forte; F., Petrucci; A., Pino; F., Marchione; Bomboi, Giuseppe; O., Senofonte; Giubilei, Franco; A., Alimonti. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 41:2(2005), pp. 197-203.

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease

BOMBOI, GIUSEPPE;GIUBILEI, Franco;
2005

Abstract

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p ≤ 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p ≤ 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).
2005
alzheimer's disease; metals; oxidative status; serum; whole blood
01 Pubblicazione su rivista::01a Articolo in rivista
Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease / B., Bocca; G., Forte; F., Petrucci; A., Pino; F., Marchione; Bomboi, Giuseppe; O., Senofonte; Giubilei, Franco; A., Alimonti. - In: ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ. - ISSN 0021-2571. - 41:2(2005), pp. 197-203.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/119144
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