INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD. The aim of this study was to identify and quantify in ADPKD, through a novel MR protocol with 3 Tesla (MRI 3Tesla), the presence of parenchymal fibrotic tissue at early stage of disease, able to correlate the glomerular filtrate and to predict the loss of the function renal. MATERIAL AND METHODS: 15 ADPKD patients undergone to renal MRI 3Tesla at T0 and revaluated after follow up (T1) of 5 years. We have evaluated renal function, plasma aldosterone concentration (PAC), insulin resistance and surrogate markers of atherosclerosis (carotid intima media thickness (IMT), ankle/brachial index (ABI) and left ventricular mass index (LVMI). RESULTS: Our study showed a significant negative correlation between total kidney volume and estimated glomerular filtration rate (eGFR) during observational observation (p<0.02). Moreover, we showed a negative correlation between eGFR with Total Fibrotic Volume (TFV) (p<0.04) and Total Perfusion Volume/Total kidney Volume(<0.02). Moreover TFV was correlated positively with PAC (p<0.05), insulin values (p<0.05), ABI (p <0.05) and LVMI(p<0.01). CONCLUSIONS: The MRI 3Tesla, despite the high costs, could be considered an useful and non-invasive method in the evaluation of fibrotic tissue and progression of the disease in ADPKD patients. Further clinical trials on larger group are due to confirm the results of this pilot study, suggesting that MRI 3Tesla can be useful to evaluate the effectiveness of new therapeutic strategies. This article is protected by copyright. All rights reserved.

Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease / Lai, Silvia; Mastroluca, Daniela; Letizia, Claudio; Petramala, Luigi; Perrotta, ADOLFO MARCO; DI GAETA, Alessandro; Luigina, Ferrigno; Ciccariello, Mauro; D'Angelo, Anna Rita; Panebianco, Valeria. - In: INTERNAL MEDICINE JOURNAL. - ISSN 1445-5994. - 48:12(2018), pp. 1505-1513. [10.1111/imj.14039]

Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease

Silvia Lai
;
Daniela Mastroluca
Membro del Collaboration Group
;
Claudio Letizia;Luigi Petramala;Adolfo Perrotta
Membro del Collaboration Group
;
DI GAETA, ALESSANDRO;Mauro Ciccariello;Anna Rita D’Angelo;Valeria Panebianco
2018

Abstract

INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD. The aim of this study was to identify and quantify in ADPKD, through a novel MR protocol with 3 Tesla (MRI 3Tesla), the presence of parenchymal fibrotic tissue at early stage of disease, able to correlate the glomerular filtrate and to predict the loss of the function renal. MATERIAL AND METHODS: 15 ADPKD patients undergone to renal MRI 3Tesla at T0 and revaluated after follow up (T1) of 5 years. We have evaluated renal function, plasma aldosterone concentration (PAC), insulin resistance and surrogate markers of atherosclerosis (carotid intima media thickness (IMT), ankle/brachial index (ABI) and left ventricular mass index (LVMI). RESULTS: Our study showed a significant negative correlation between total kidney volume and estimated glomerular filtration rate (eGFR) during observational observation (p<0.02). Moreover, we showed a negative correlation between eGFR with Total Fibrotic Volume (TFV) (p<0.04) and Total Perfusion Volume/Total kidney Volume(<0.02). Moreover TFV was correlated positively with PAC (p<0.05), insulin values (p<0.05), ABI (p <0.05) and LVMI(p<0.01). CONCLUSIONS: The MRI 3Tesla, despite the high costs, could be considered an useful and non-invasive method in the evaluation of fibrotic tissue and progression of the disease in ADPKD patients. Further clinical trials on larger group are due to confirm the results of this pilot study, suggesting that MRI 3Tesla can be useful to evaluate the effectiveness of new therapeutic strategies. This article is protected by copyright. All rights reserved.
2018
autosomal dominant polycystic kidney disease; total volume fibrotic; plasma aldosterone; subclinical atherosclerosis parameters
01 Pubblicazione su rivista::01a Articolo in rivista
Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease / Lai, Silvia; Mastroluca, Daniela; Letizia, Claudio; Petramala, Luigi; Perrotta, ADOLFO MARCO; DI GAETA, Alessandro; Luigina, Ferrigno; Ciccariello, Mauro; D'Angelo, Anna Rita; Panebianco, Valeria. - In: INTERNAL MEDICINE JOURNAL. - ISSN 1445-5994. - 48:12(2018), pp. 1505-1513. [10.1111/imj.14039]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1190240
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