Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. © 2009 Elsevier Ltd. All rights reserved.
GIGYF2 mutations are not a frequent cause of familial Parkinson's disease / Berardelli, Alfredo; E., Fabrizio; A., Thomas; Emiliana, Fincati; Roberto, Marconi; Michele, Tinazzi; Guido J., Breedveld; Erik J., Simons; Hsin F., Chien; Joaquim J., Ferreira; Martin W., Horstink; Giovanni, Abbruzzese; Barbara, Borroni; Giovanni, Cossu; A., Dalla Libera; Fabbrini, Giovanni; Marco, Guidi; Michele De, Mari; Leonardo, Lopiano; Emilia, Martignoni; Paolo, Marini; Marco, Onofrj; Alessandro, Padovani; Fabrizio, Stocchi; Vincenzo, Toni; Cristina, Sampaio; Egberto R., Barbosa; Meco, Giuseppe; Genetics Network Italian, Parkinson; Ben A., Oostra; Vincenzo, Bonifati. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - 15:9(2009), pp. 703-705. [10.1016/j.parkreldis.2009.05.001]
GIGYF2 mutations are not a frequent cause of familial Parkinson's disease
BERARDELLI, Alfredo;FABBRINI, Giovanni;MECO, Giuseppe;
2009
Abstract
Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. © 2009 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
