Interobserver reliability of rheumatologists performing musculoskeletal ultrasonography: results from a EULAR ''Train the trainers'' course

Scheel, A. K.; Schmidt, W. A.; Hermann, K. G. A.; Bruyn, G. A.; D'Agostino, M. A.; Grassi, W.; Iagnocco, Annamaria; Koski, J. M.; Machold, K. P.; Naredo, E.; Sattler, H.; Swen, N.; Szkudlarek, M.; Wakefield, R. J.; Ziswiler, H. R.; Pasewaldt, D.; Werner, C.; Backhaus, M.

doi:10.1136/ard.2004.030387

Objective: To evaluate the interobserver reliability among 14 experts in musculoskeletal ultrasonography ( US) and to determine the overall agreement about the US results compared with magnetic resonance imaging (MRI), which served as the imaging "gold standard''. Methods: The clinically dominant joint regions ( shoulder, knee, ankle/toe, wrist/finger) of four patients with inflammatory rheumatic diseases were ultrasonographically examined by 14 experts. US results were compared with MRI. Overall agreements, sensitivities, specificities, and interobserver reliabilities were assessed. Results: Taking an agreement in US examination of 10 out of 14 experts into account, the overall kappa for all examined joints was 0.76. Calculations for each joint region showed high kappa values for the knee ( 1), moderate values for the shoulder ( 0.76) and hand/finger (0.59), and low agreement for ankle/toe joints (0.28). kappa Values for bone lesions, bursitis, and tendon tears were high (kappa = 1). Relatively good agreement for most US findings, compared with MRI, was found for the shoulder ( overall agreement 81%, sensitivity 76%, specificity 89%) and knee joint ( overall agreement 88%, sensitivity 91%, specificity 88%). Sensitivities were lower for wrist/finger ( overall agreement 73%, sensitivity 66%, specificity 88%) and ankle/toe joints ( overall agreement 82%, sensitivity 61%, specificity 92%). Conclusion: Interobserver reliabilities, sensitivities, and specificities in comparison with MRI were moderate to good. Further standardisation of US scanning techniques and definitions of different pathological US lesions are necessary to increase the interobserver agreement in musculoskeletal US. Univ Gottingen, Dept Nephrol & Rheumatol, D-3400 Gottingen, Germany; Med Ctr Rheumatol Berlin Buch, Berlin, Germany; Charite Univ Hosp, Dept Radiol, Berlin, Germany; Med Centrum Leeuwarden, Dept Rheumatol, Leeuwarden, Netherlands; UVSQ Univ, Ambroise Pare Hosp, Dept Rheumatol, Boulogne Billancourt, France; Univ Ancona, Osped A Murri, Dept Rheumatol, Ancona, Italy; Univ Roma La Sapienza, Dept Rheumatol, Rome, Italy; Mikkeli Cent Hosp, Dept Rheumatol, Mikkeli, Finland; Univ Vienna, Vienna Gen Hosp, Dept Rheumatol, A-1010 Vienna, Austria; Severo Ochoa Hosp, Dept Rheumatol, Res Unit, Madrid, Spain; Severo Ochoa Hosp, Epidemiol Unit, Madrid, Spain; Parkklin, Dept Rheumatol, Bad Durkheim, Germany; Med Centrum Alkmaar, Dept Rheumatol, Alkmaar, Netherlands; Univ Copenhagen, Hvidovre Hosp, Dept Rheumatol, DK-1168 Copenhagen, Denmark; Leeds Gen Hosp, Acad Dept Musculoskeletal Med, Leeds, W Yorkshire, England; Inselspital Bern, Dept Rheumatol & Clin Immunol, CH-3010 Bern, Switzerland; Univ Gottingen, Dept Med Stat, D-3400 Gottingen, Germany; Charite Univ Hosp, Dept Rheumatol & Clin Immunol, Berlin, Germany Scheel, AK (reprint author), Dept Med Nephrol & Rheumatol, Robert Koch Str 40, D-37075 Gottingen, Germany. ascheel@gwdg.de 28 93 93 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0003-4967 ANN RHEUM DIS Ann. Rheum. Dis. JUL 2005 64 7 1043 1049 10.1136/ard.2004.030387 7 Rheumatology Rheumatology 935YF WOS:000229818600013 J Navia, JL; Atik, FA; Marullo, A; Starling, RC; Garcia, M; Vega, PR; Smedira, NG; McCarthy, PM Navia, JL; Atik, FA; Marullo, A; Starling, RC; Garcia, M; Vega, PR; Smedira, NG; McCarthy, PM Bench repair of donor aortic valve with minimal access orthotopic heart transplantation ANNALS OF THORACIC SURGERY English Article While the number of people waiting heart transplantation increases, the number of organ donors decreases. This shrinking donor pool has prompted reassessment of donor selection for heart transplantation. Bench repair of a donor aortic valve was performed before minimal access orthotopic heart transplantation. Aortic insufficiency in the structurally normal tricuspid aortic valve was due to annular dilatation and was corrected with subcommissural annular plication. The postoperative period was uneventful. Follow-up at 4.5 years showed good results and no evidence of aortic regurgitation. (c) 2005 by The Society of Thoracic Surgeons. Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, Cleveland, OH 44195 USA Navia, JL (reprint author), Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, Desk F-25,9500 Euclid Ave, Cleveland, OH 44195 USA. naviaj@ccf.org 10 5 5 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0003-4975 ANN THORAC SURG Ann. Thorac. Surg. JUL 2005 80 1 313 315 10.1016/j.athoracsur.2004.01.030 3 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 941LG WOS:000230215700051 J D'Andrilli, A; Ibrahim, M; Venuta, F; De Giacomo, T; Coloni, F; Rendina, EA D'Andrilli, A; Ibrahim, M; Venuta, F; De Giacomo, T; Coloni, F; Rendina, EA Glutaraldehyde preserved autologous pericardium for patch reconstruction of the pulmonary artery and superior vena cava ANNALS OF THORACIC SURGERY English Editorial Material LUNG-CANCER; RESECTION We describe a new employment of glutaraldehyde preserved autologous pericardium for patch reconstruction of the pulmonary artery (PA) and superior vena cava (SVC). This technique was devised to minimize technical problems related to the use of fresh pericardium such as excessive elasticity and tendency to curl. We have successfully employed this procedure in three cases of reconstruction of the PA and in two cases of reconstruction of the SVC. (c) 2005 by The Society of Thoracic Surgeons. St Andrea Hosp, Div Thorac Surg, I-00161 Rome, Italy; Univ Roma La Sapienza, Policlin Umberto I, Rome, Italy Rendina, EA (reprint author), St Andrea Hosp, Div Thorac Surg, Via Grottarossa 1035, I-00161 Rome, Italy. erinoangelo.rendina@tin.it 6 13 13 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0003-4975 ANN THORAC SURG Ann. Thorac. Surg. JUL 2005 80 1 357 358 10.1016/j.athoracsur.2004.02.012 2 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 941LG WOS:000230215700073 J Tombolini, V; Raffetto, N; Santarelli, M; Valeriani, M; Necozione, S; Masedu, F; Enrici, RM Tombolini, V; Raffetto, N; Santarelli, M; Valeriani, M; Necozione, S; Masedu, F; Enrici, RM Carcinoma of the vulva: Clinical results of exclusive and adjuvant radiotherapy ANTICANCER RESEARCH English Article vulvar cancer; exclusive radiotherapy; adjuvant radiotherapy; surgery SQUAMOUS-CELL CARCINOMA; GYNECOLOGIC-ONCOLOGY-GROUP; PROGNOSTIC FACTORS; CANCER; MANAGEMENT; RADIATION; CHEMORADIATION; CHEMOTHERAPY; RECURRENCE; SURGERY Background: The aim of this study was to evaluate the historical cohort of 61 patients with carcinoma of the vulva, treated with radiation therapy from 1986 to 1997 Patients and Methods: Twenty-seven patients were submitted to radiation therapy alone and 34 received radiotherapy post limited surgery in early stages and post radical vulvectomy in advanced stages. The dose range varied from 59 to 63 Gy in post-operative patients and 65 Gy to 71 Gy in curative patients. Results: Five-year Overall Survival (OS) and Disease-Free Survival (DFS) for patients treated with irradiation alone and for those treated with post-operative radiotherapy were 50.8% and 69.7%, respectively, without significant statistical difference. For OS multivariate analysis showed statistical difference for stage and age variables, and for stage variable in the case of DFS. Conclusion: In early stage vulvar cancer patients OS and DFS are good, with high control rate and low incidence of adverse effect. In loco-regionally-advanced patients, especially in those with stage IV or with > 2 positive lymph nodes, the outcomes are poor. Osped S Salvatore, UO Radioterapia, Dept Expt Med, I-67100 Laquila, Italy; Univ Roma La Sapienza, Dept Radiol, Rome, Italy; Univ Aquila, Dept Internal Med & Publ Hlth, I-67100 Laquila, Italy Tombolini, V (reprint author), Osped S Salvatore, UO Radioterapia, Dept Expt Med, Via Vetoio, I-67100 Laquila, Italy. tmbolini52@ciaoweb.it 32 3 3 INT INST ANTICANCER RESEARCH ATHENS EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE 0250-7005 ANTICANCER RES Anticancer Res. JUL-AUG 2005 25 4 3089 3094 6 Oncology Oncology 949PA WOS:000230799400072 J Fatone, L; Recchioni, MC; Scoccia, A; Zirilli, F Fatone, L; Recchioni, MC; Scoccia, A; Zirilli, F The behavior of smart obstacles in electromagnetic scattering: mathematical models as optimal control problems APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL English Article FURTIVITY; ABSORBER We consider a bounded obstacle characterized by a boundary electromagnetic impedance contained in the three dimensional real Euclidean space filled with a homogeneous isotropic medium. When an incoming electromagnetic field illuminates the obstacle a scattered field is generated. A smart obstacle is an obstacle that in the scattering process, circulating a surface electric current density on its boundary, tries to achieve a given goal. We consider four possible goals: making the obstacle undetectable (i.e.: furtivity problem), making the obstacle to appear with a shape and impedance different from its actual ones (i.e.: masking problem), making the obstacle to appear in a location different from its actual one eventually with a shape and impedance different from its actual ones (i.e.: ghost obstacle problem) and finally one of the previous goals limited to a given subset of the frequency space (i.e.: definite band problems). We consider the problem of determining the optimal electric current density to achieve the given goal. The relevance in many application fields (i.e. stealth technology, electromagnetic noise control, etc.) of these problems is well known. The previous problems are modelled as optimal control problems for the Maxwell equations. Some numerical results on test problems obtained solving the optimal control problems proposed are shown. Univ Modena & Reggio Emilia, Dipartimento Matemat Pura & Applicata, Modena, Italy; Univ Politecn Marche, Dipartimento Sci Sociali D Serrani, Ancona, Italy; Univ Roma La Sapienza, Dipartimento Matemat G Castelnuovo, I-00185 Rome, Italy Fatone, L (reprint author), Univ Modena & Reggio Emilia, Dipartimento Matemat Pura & Applicata, Modena, Italy. 11 1 1 APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY UNIVERSITY UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA 1054-4887 APPL COMPUT ELECTROM Appl. Comput. Electromagn. Soc. J. JUL 2005 20 2 119 127 9 Engineering, Electrical & Electronic; Telecommunications Engineering; Telecommunications 953QU WOS:000231095000003 J Asquini, R; Fratalocchi, A; d'Alessandro, A; Assanto, G Asquini, R; Fratalocchi, A; d'Alessandro, A; Assanto, G Electro-optic routing in a nematic liquid-crystal waveguide APPLIED OPTICS English Article SILICON-ON-INSULATOR; 2-MODE INTERFERENCE; DIRECTIONAL COUPLER; SWITCH; MODULATOR; DEVICES; LIGHT We propose a versatile guided-wave geometry encompassing electro-optic control for signal routing. A zero-gap directional coupler in liquid crystal can switch between two output states in the guide plane, permitting signal rerouting with modulation voltages as small as 70 mV. In the absence of an applied bias, no guiding-hence no modal output-is provided by the structure. (c) 2005 Optical Society of America. Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy; Univ Roma La Sapienza, INFM, I-00184 Rome, Italy; Univ Roma Tor Vergata, Dept Elect Engn, Nonlinear Opt & OptoElect Lab, I-00146 Rome, Italy; Univ Roma Tor Vergata, Ist Nazl Fis Mat, I-00146 Rome, Italy Asquini, R (reprint author), Univ Roma La Sapienza, Dept Elect Engn, Via Eudossiana 18, I-00184 Rome, Italy. rita.asquini@uniroma1.it d'Alessandro, Antonio/B-4223-2010; Asquini, Rita/G-8796-2011 33 10 10 OPTICAL SOC AMER WASHINGTON 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA 1559-128X APPL OPTICS Appl. Optics JUL 1 2005 44 19 4136 4143 10.1364/AO.44.004136 8 Optics Optics 940OM WOS:000230153800033 J Larciprete, MC; Savalli, N; Tenev, T; Scalora, M; Leahu, G; Sibilia, C; Baglio, S; Panajotov, K; Bertolotti, M Larciprete, MC; Savalli, N; Tenev, T; Scalora, M; Leahu, G; Sibilia, C; Baglio, S; Panajotov, K; Bertolotti, M Optical switching applications of ZnSe/MgF2 photonic band gap structures based on thermal nonlinearities APPLIED PHYSICS B-LASERS AND OPTICS English Article We investigate a thermo-optical device based on a ZnSe/MgF2 multilayer and demonstrate the modulation of its optical reflectance around the band edge. An electrically induced temperature increase is responsible for the change of the refractive indices of the layers. As a result, the reflection spectrum shifts and the reflected signal decreases. The structure was grown using a thermal evaporation technique, and was designed in such a way that a band edge appears at 632.8 nm, i.e. accessible to a low-power He-Ne laser. The reflection characteristics were investigated as a function of the applied voltage and we found that the photonic band edge shifts by a maximum of 7 nm for an applied voltage of 90 V. Furthermore, different sets of measurements have shown that the spectral shift depends on the voltage squared, thus allowing experimental data analysis in terms of the thermally driven optical nonlinearity. Univ Roma La Sapienza, INFM, Dipartimento Energet, I-00161 Rome, Italy; Univ Catania, Dipartimento Elettr & Sistemist, I-95124 Catania, Italy; Inst Solid State Phys, BU-1784 Sofia, Bulgaria; USA, Aviat & Missile Command, Weap Sci Directorate, AMSAM,RD,WS,ST Redstone Arsenal, Huntsville, AL 35898 USA Larciprete, MC (reprint author), Univ Roma La Sapienza, INFM, Dipartimento Energet, Via A Scarpa 16, I-00161 Rome, Italy. mariacristina.larciprete@uniroma1.it Baglio, Salvatore/I-3174-2012 9 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 245 249 10.1007/s00340-005-1837-y 5 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000018 J Apetrei, AM; Moison, JM; Levenson, JA; Foroni, M; Poli, F; Cucinotta, A; Selleri, S; Legre, M; Wegmuller, M; Gisin, N; Dukel'skii, KV; Khokhlov, AV; Shevandin, VS; Kondrat'ev, YN; Sibilia, C; Serebryannikov, EE; Zheltikov, AM Apetrei, AM; Moison, JM; Levenson, JA; Foroni, M; Poli, F; Cucinotta, A; Selleri, S; Legre, M; Wegmuller, M; Gisin, N; Dukel'skii, KV; Khokhlov, AV; Shevandin, VS; Kondrat'ev, YN; Sibilia, C; Serebryannikov, EE; Zheltikov, AM Electromagnetic field confined and tailored with a few air holes in a photonic-crystal fiber APPLIED PHYSICS B-LASERS AND OPTICS English Article MICROSTRUCTURED OPTICAL-FIBER; FEMTOSECOND LASER-PULSES; WAVE-GUIDE ENHANCEMENT; SELF-FREQUENCY SHIFT; SUPERCONTINUUM GENERATION; HOLLOW-CORE; FLATTENED DISPERSION; RAMAN-SCATTERING; CONVERSION; LIGHT Conventional and scanning near-field optical microscopy techniques are cross referenced to femtosecond nonlinear-optical measurements and finite-element numerical simulations to visualize and analyze a strong confinement of electromagnetic radiation in guided modes of a photonic-crystal fiber with only a few air holes surrounding the fiber core. A nonlinear coefficient of about 120 W-1 km(-1) is achieved at the wavelength of 670 nm for a fused-silica fiber with a full hexagonal cycle of closely packed air holes around the fiber core. The removal of a single element from this array of air holes is shown to frustrate field confinement in guided modes, leading to mode leakage. Moscow MV Lomonosov State Univ, Ctr Int Laser, Dept Phys, Moscow 119992, Russia; LPN, CNRS, Route Nozay, F-91460 Marcoussis, France; Univ Parma, Dept Informat Engn, I-43100 Parma, Italy; Univ Geneva, Sect Phys GAP Opt, CH-1211 Geneva, Switzerland; SI Vavilov State Opt Inst, St Petersburg 199034, Russia; Univ Roma La Sapienza, Dipartimento Energet, I-00161 Rome, Italy Zheltikov, AM (reprint author), Moscow MV Lomonosov State Univ, Ctr Int Laser, Dept Phys, Vorobevy Gory, Moscow 119992, Russia. zheltikov@phy.msu.ru APETREI, ALIN MARIAN/B-5811-2013; Selleri, Stefano/K-1343-2013 APETREI, ALIN MARIAN/0000-0002-2036-7139; 53 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 409 414 10.1007/s00340-005-1855-9 6 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000043 J Di Falco, A; Conti, C; Assanto, G Di Falco, A; Conti, C; Assanto, G Transient-mode excitation, terahertz generation and wavelength shifting in a photonic band gap APPLIED PHYSICS B-LASERS AND OPTICS English Article PARAMETRIC OSCILLATIONS; ISOTROPIC MEDIA; CRYSTAL SLABS; WAVE-GUIDES; MICROCAVITIES; PROPAGATION Dynamic responses of photonic crystal microcavities in nonlinear media are analyzed via both a finite-difference code and coupled-mode theory in the time domain. Optical frequency generation in both second- and third-order nonlinear materials is demonstrated based on the transient evolution of cavity modes. Terahertz waves can be generated in quadratically nonlinear crystals by optical rectification, whereas state generation inside the band gap can be linked to a Rabi-like splitting in cubic media. An all-optical ultra-fast wavelength shifter is proposed. Univ Roma Tre, Dept Elect Engn, INFM, Nonlinear & Optoelect Lab, I-00146 Rome, Italy; Ctr E Fermi, I-00184 Rome, Italy; Univ Palermo, Dept Elect Engn, I-90128 Palermo, Italy; Univ Roma La Sapienza, INFM, CRS SOFT, I-00185 Rome, Italy Di Falco, A (reprint author), Univ Roma Tre, Dept Elect Engn, INFM, Nonlinear & Optoelect Lab, Via Vasca Navale 84, I-00146 Rome, Italy. difalco@ele.uniroma3.it Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 30 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 415 420 10.1007/s00340-005-1885-3 6 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000044 J Gallo, A; Manciocco, V; Simonelli, M; Pagliuca, G; D'Arcangelo, E; de Vincentiis, M Gallo, A; Manciocco, V; Simonelli, M; Pagliuca, G; D'Arcangelo, E; de Vincentiis, M Supracricoid partial laryngectomy in the treatment of laryngeal cancer - Univariate and multivariate analysis of prognostic factors ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY English Article; Proceedings Paper 6th International Conference on Head and Neck Cancer AUG 09, 2004 Washington, DC Amer Head & Neck Soc SUPRAGLOTTIC CARCINOMA; GLOTTIC CARCINOMA; CRICOHYOIDOPEXY; CRICOHYOIDOEPIGLOTTOPEXY; MANAGEMENT; RESECTION Objectives: To evaluate the oncological results of supracricoid partial laryngectomy as a treatment for selected glottic and supraglottic cancer in a large series of patients who had undergone uniform treatment over a 16-year period and to determine the different prognostic factors that may influence local control and survival. Design: Retrospective clinical study. Setting: Academic tertiary referral medical center. Patients: The study population comprised 253 consecutive patients (234 men and 19 women) with glottic and supraglottic squamous cell carcinoma. The mean age was 58 years for men and 59.2 years for women. Intervention: Supracricoid partial laryngectomy: 180 patients had undergone cricohyoidopexy and 73 had undergone cricohyoidoepiglottopexy. Main Outcome Measures: Local control and overall survival. Potential prognostic factors for local control and survival were evaluated with univariate and multivariate models. Results: The 3-, 5-, 10-, and 16-year overall survival rates in this group of 253 patients were 85.8%, 79.1%, 57.6%, and 57.6%, respectively. With regard to local control, univariate and multivariate analyses showed that a positive resection margin was the only important predictor of local control and that a dysplastic lesion at the margin of resection is just as aggressive as the presence of invasive carcinoma. When considering the prognostic factors influencing survival, univariate analysis showed that the tumor category, lymph node category, tumor stage, and recurrence all had a significant influence on the survival rate. Multivariate analysis showed that the most important predictor of survival was recurrence. Conclusions: Supracricoid partial laryngectomy is a valid choice in the treatment of selected glottic and supraglottic cancer while maintaining laryngeal functions and achieving a high rate of local control. T category, N category, tumor stage, positive resection margins, and recurrence are the most important predictors of oncological outcome. Univ Roma La Sapienza, Dept Otorhinolaryngol, Rome, Italy; Univ Roma La Sapienza, Dept Stat, Rome, Italy; St Lucia Hosp, Speech & Swallowing Rehabil Serv, Rome, Italy Gallo, A (reprint author), Via Adolfo Venturi 19, I-00162 Rome, Italy. andrea.gallo@uniroma1.it 25 28 30 AMER MEDICAL ASSOC CHICAGO 515 N STATE ST, CHICAGO, IL 60610 USA 0886-4470 ARCH OTOLARYNGOL Arch. Otolaryngol. Head Neck Surg. JUL 2005 131 7 620 625 10.1001/archotol.131.7.620 6 Otorhinolaryngology; Surgery Otorhinolaryngology; Surgery 944EO WOS:000230409300015 J Raiteri, CM; Villata, M; Ibrahimov, MA; Larionov, VM; Kadler, M; Aller, HD; Aller, MF; Kovalev, YY; Lanteri, L; Nilsson, K; Papadakis, IE; Pursimo, T; Romero, GE; Terasranta, H; Tornikoski, M; Arkharov, AA; Barnaby, D; Berdyugin, A; Bottcher, M; Byckling, K; Carini, MT; Carosati, D; Cellone, SA; Ciprini, S; Combi, JA; Crapanzano, S; Crowe, R; Di Paola, A; Dolci, M; Fuhrmann, L; Gu, M; Hagen-Thorn, VA; Hakala, P; Impellizzeri, V; Jorstad, S; Kerp, J; Kimeridze, GN; Kovalev, YA; Kraus, A; Krichbaum, TP; Kurtanidze, OM; Lahteenmaki, A; Lindfors, E; Mingaliev, MG; Nesci, R; Nikolashvili, MG; Ohlert, J; Orio, M; Ostorero, L; Pasanen, M; Pati, A; Poteet, C; Ros, E; Ros, JA; Shastri, P; Sigua, LA; Sillanpaa, A; Smith, N; Takalo, LO; Tosti, G; Vasileva, A; Wagner, SJ; Walters, R; Webb, JR; Wills, W; Witzel, A; Xilouris, E Raiteri, CM; Villata, M; Ibrahimov, MA; Larionov, VM; Kadler, M; Aller, HD; Aller, MF; Kovalev, YY; Lanteri, L; Nilsson, K; Papadakis, IE; Pursimo, T; Romero, GE; Terasranta, H; Tornikoski, M; Arkharov, AA; Barnaby, D; Berdyugin, A; Bottcher, M; Byckling, K; Carini, MT; Carosati, D; Cellone, SA; Ciprini, S; Combi, JA; Crapanzano, S; Crowe, R; Di Paola, A; Dolci, M; Fuhrmann, L; Gu, M; Hagen-Thorn, VA; Hakala, P; Impellizzeri, V; Jorstad, S; Kerp, J; Kimeridze, GN; Kovalev, YA; Kraus, A; Krichbaum, TP; Kurtanidze, OM; Lahteenmaki, A; Lindfors, E; Mingaliev, MG; Nesci, R; Nikolashvili, MG; Ohlert, J; Orio, M; Ostorero, L; Pasanen, M; Pati, A; Poteet, C; Ros, E; Ros, JA; Shastri, P; Sigua, LA; Sillanpaa, A; Smith, N; Takalo, LO; Tosti, G; Vasileva, A; Wagner, SJ; Walters, R; Webb, JR; Wills, W; Witzel, A; Xilouris, E The WEBT campaign to observe AO 0235+16 in the 2003-2004 observing season - Results from radio-to-optical monitoring and XMM-Newton observations ASTRONOMY & ASTROPHYSICS English Article galaxies : active; BL Lacertae objects : general; BL Lacertae objects : individual : AO 0235+16 BL-LACERTAE OBJECTS; ACTIVE GALACTIC NUCLEI; X-RAY-SPECTRA; INTRADAY VARIABILITY; AO 0235+164; INTERSTELLAR SCINTILLATION; LIGHT CURVES; RAPID VARIABILITY; EGRET BLAZARS; LOUD BLAZARS A multiwavelength campaign to observe the BL Lac object AO 0235+ 16 ( z = 0.94) was set up by the Whole Earth Blazar Telescope (WEBT) collaboration during the observing seasons 2003-2004 and 2004-2005, involving radio, near-IR and optical photometric monitoring, VLBA monitoring, optical spectral monitoring, and three pointings by the XMM-Newton satellite. Here we report on the results of the first season, which involved the participation of 24 optical and near-IR telescopes and 4 radio telescopes, as well as the first XMM-Newton pointing, which occurred on January 18-19, 2004. Unpublished data from previous epochs were also collected ( from 5 optical-NIR and 3 radio telescopes), in order to fill the gap between the end of the period presented in Raiteri et al. ( 2001) and the start of the WEBT campaign. The contribution of the southern AGN, 2 arcsec distant from the source, is taken into account. It is found to especially affect the blue part of the optical spectrum when the source is faint. In the optical and near-IR the source has been very active in the last 3 years, although it has been rather faint most of the time, with noticeable variations of more than a magnitude over a few days. In contrast, in the radio bands it appears to have been "quiescent" since early 2000. The major radio ( and optical) outburst predicted to peak around February-March 2004 ( with a six month uncertainty) has not occurred yet. When comparing our results with the historical light curves, two different behaviours seem to characterize the optical outbursts: only the major events present a radio counterpart. The X-ray spectra obtained by the three EPIC detectors are well fitted by a power law with extra-absorption at z = 0.524; the energy index in the 0.2-10 keV range is well constrained: alpha = 0.645 +/- 0.028 and the 1 keV flux density is 0.311 +/- 0.008 mu Jy. The analysis of the X-ray light curves reveals that no significant variations occurred during the pointing. In contrast, simultaneous dense radio monitoring with the 100 m telescope at Effelsberg shows a similar to 2 - 3% flux decrease in 6 - 7 h, which, if intrinsic, would imply a brightness temperature well above the Compton limit and hence a lower limit to the Doppler factor delta greater than or similar to 46. We construct the broad-band spectral energy distribution of January 18 - 19, 2004 with simultaneous radio data from Effelsberg, optical data from the Nordic Optical Telescope ( NOT), optical-UV data from the Optical Monitor onboard XMM-Newton, and X-ray data by the EPIC instruments. Particular care is taken to correct data for extinction due to both the Milky Way and the z = 0.524 absorber. The resulting SED suggests the existence of a bump in the UV spectral region. Osserv Astron Torino, INAF, Turin, Italy; St Petersburg State Univ, Astron Inst, St Petersburg, Russia; Univ Michigan, Dept Astron, Ann Arbor, MI 48109 USA; Natl Radio Astron Observ, Green Bank, WV USA; PN Lebedev Phys Inst, Ctr Astro Space, Moscow, Russia; Tuorla Astron Observ, Piikkio, Finland; Univ Crete, Dept Phys, Rethimnon, Greece; Nord Opt Telescope, Santa Cruz De La Palma, Spain; Helsinki Univ Technol, Metsahovi Radio Observ, FIN-02150 Espoo, Finland; Pulkovo Observ, St Petersburg, Russia; Western Kentucky Univ, Dept Phys & Astron, Bowling Green, KY 42101 USA; Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA; Univ Helsinki, Observ, FIN-00014 Helsinki, Finland; Univ Jaen, Dept Fis, Escuela Politecn Super, Jaen, Spain; Univ Hawaii, Dept Phys & Astron, Honolulu, HI 96822 USA; Osserv Astron Roma, INAF, Rome, Italy; Univ Perugia, Osservatorio Astron, I-06100 Perugia, Italy; Boston Univ, Inst Astrophys Res, Boston, MA 02215 USA; Abastumani Observ, Abastumani, Rep of Georgia; Special Astrophys Observ, Karachaevo Cherkessia, Russia; Univ Roma La Sapienza, Dipartimento Fis, Rome, Italy; Michael Adrian Observ, Trebur, Germany; Landessternwarte Konigstuhl, D-6900 Heidelberg, Germany; Indian Inst Astrophys, Bangalore 560034, Karnataka, India; Cork Inst Technol, Dept Appl Phys & Instrumentat, Cork, Ireland; Florida Int Univ, SARA Observ, Miami, FL 33199 USA; Natl Observ Athens, Inst Astron & Astrophys, Athens, Greece Raiteri, CM (reprint author), Osserv Astron Torino, INAF, Turin, Italy. villata@to.astro.it Papadakis, Iossif/C-3235-2011; Tosti, Gino/E-9976-2013; Larionov, Valeri/H-1349-2013; Xilouris, Emmanuel/K-9459-2013; Kovalev, Yuri/J-5671-2013 73 44 46 EDP SCIENCES LES ULIS CEDEX A 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE 0004-6361 ASTRON ASTROPHYS Astron. Astrophys. JUL 2005 438 1 39 53 10.1051/0004-6361:20042567 15 Astronomy & Astrophysics Astronomy & Astrophysics 943XC WOS:000230387800008 J De Rosa, A; Piro, L; Tramacere, A; Massaro, E; Walter, R; Bassani, L; Malizia, A; Bird, AJ; Dean, AJ De Rosa, A; Piro, L; Tramacere, A; Massaro, E; Walter, R; Bassani, L; Malizia, A; Bird, AJ; Dean, AJ The broad-band X-ray spectrum of the blazar PKSB1830-211 by Chandra and INTEGRAL ASTRONOMY & ASTROPHYSICS English Article radiation mechanisms : non-thermal; galaxies : active; X-rays : galaxies : individual : PKSB1830-211 GRAVITATIONAL LENS; RADIO-SOURCE; PKS-1830-211; EMISSION; REDSHIFT; QUASARS; CATALOG; PKS1830-211; ABSORPTION; Z=4.4 In this paper we present a broad-band study of the X-ray emission of the blazar PKS 1830-211 based on Chandra and INTEGRAL observations. Notwithstanding the high redshift ( z = 2.507), it is a bright X-ray source (F(2 - 10 keV) similar or equal to 10(-11) erg cm(-2) s(-1)), due to gravitational lensing by an intervening galaxy at z = 0.89. Previous X-ray observations attribute the observed absorption at E < 2 keV to the lensing galaxy. Our analysis, although not in contrast with this hypothesis, suggests also the possibility of an intrinsic ( ionized) absorption, taking place at the front side of the jet. This scenario is also supported by some evidence, in the same data, of a feature observed at 2.15 keV which can be interpreted as a blueshifted iron line (v/ c similar or equal to 0.18). The SED of PKS 1830-211 can be well modelled by combining a Synchrotron Self-Compton component and an external source of photons to be scattered up to gamma-ray energies by relativistic electrons moving outward in the jet. The main source of low energy photons is a dust torus at the temperature of 103 K as expected in MeV blazars. INAF, IASF, Sez Roma, I-00113 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Observ Geneva, INTEGRAL Sci Data Ctr, CH-1291 Versoix, Switzerland; INAF, IASF Sez Bologna, I-40129 Bologna, Italy; Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, Hants, England De Rosa, A (reprint author), INAF, IASF, Sez Roma, Via Fosso Cavaliere 100, I-00113 Rome, Italy. derosa@rm.iasf.cnr.it 33 23 23 EDP SCIENCES LES ULIS CEDEX A 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE 0004-6361 ASTRON ASTROPHYS Astron. Astrophys. JUL 2005 438 1 121 126 10.1051/000-6361:20052710 6 Astronomy & Astrophysics Astronomy & Astrophysics 943XC WOS:000230387800013 J Braccini, S; Barsotti, L; Bradaschia, C; Cella, G; Di Virgilio, A; Ferrante, I; Fidecaro, F; Fiori, I; Frasconi, F; Gennai, A; Giazotto, A; Paoletti, F; Passaquieti, R; Passuello, D; Poggiani, R; Campagna, E; Guidi, G; Losurdo, G; Martelli, F; Mazzoni, M; Perniola, B; Piergiovanni, F; Stanga, R; Vetrano, F; Vicere, A; Brocco, L; Frasca, S; Majorana, E; Pai, A; Palomba, C; Puppo, P; Rapagnani, P; Ricci, F; Ballardin, G; Barille, R; Cavalieri, R; Cuoco, E; Dattilo, V; Enard, D; Flaminio, R; Freise, A; Hebri, S; Holloway, L; La Penna, P; Loupias, M; Marque, J; Moins, C; Pasqualetti, A; Ruggi, P; Taddei, R; Zhang, Z; Acernese, F; Avino, S; Barone, F; Calloni, E; De Rosa, R; Di Fiore, L; Eleuteri, A; Giordano, L; Milano, L; Pardi, S; Qipiani, K; Ricciardi, I; Russo, G; Solimeno, S; Babusci, D; Giordano, G; Amico, P; Bosi, L; Gammaitoni, L; Marchesoni, F; Punturo, M; Travasso, F; Vocca, H; Boccara, C; Moreau, J; Loriette, V; Reita, V; Mackowski, JM; Morgado, N; Pinard, L; Remillieux, A; Barsuglia, M; Bizouard, MA; Brisson, V; Cavalier, F; Clapson, AC; Davier, M; Hello, P; Krecklbergh, S; Beauville, F; Buskulic, D; Gouaty, R; Grosjean, D; Marion, F; Masserot, A; Mours, B; Tournefier, E; Tombolato, D; Verkindt, D; Yvert, M; Aoudia, S; Bondu, F; Brillet, A; Chassande-Mottin, E; Cleva, F; Coulon, JP; Dujardin, B; Fournier, JD; Heitmann, H; Man, CN; Spallicci, A; Vinet, JY Braccini, S; Barsotti, L; Bradaschia, C; Cella, G; Di Virgilio, A; Ferrante, I; Fidecaro, F; Fiori, I; Frasconi, F; Gennai, A; Giazotto, A; Paoletti, F; Passaquieti, R; Passuello, D; Poggiani, R; Campagna, E; Guidi, G; Losurdo, G; Martelli, F; Mazzoni, M; Perniola, B; Piergiovanni, F; Stanga, R; Vetrano, F; Vicere, A; Brocco, L; Frasca, S; Majorana, E; Pai, A; Palomba, C; Puppo, P; Rapagnani, P; Ricci, F; Ballardin, G; Barille, R; Cavalieri, R; Cuoco, E; Dattilo, V; Enard, D; Flaminio, R; Freise, A; Hebri, S; Holloway, L; La Penna, P; Loupias, M; Marque, J; Moins, C; Pasqualetti, A; Ruggi, P; Taddei, R; Zhang, Z; Acernese, F; Avino, S; Barone, F; Calloni, E; De Rosa, R; Di Fiore, L; Eleuteri, A; Giordano, L; Milano, L; Pardi, S; Qipiani, K; Ricciardi, I; Russo, G; Solimeno, S; Babusci, D; Giordano, G; Amico, P; Bosi, L; Gammaitoni, L; Marchesoni, F; Punturo, M; Travasso, F; Vocca, H; Boccara, C; Moreau, J; Loriette, V; Reita, V; Mackowski, JM; Morgado, N; Pinard, L; Remillieux, A; Barsuglia, M; Bizouard, MA; Brisson, V; Cavalier, F; Clapson, AC; Davier, M; Hello, P; Krecklbergh, S; Beauville, F; Buskulic, D; Gouaty, R; Grosjean, D; Marion, F; Masserot, A; Mours, B; Tournefier, E; Tombolato, D; Verkindt, D; Yvert, M; Aoudia, S; Bondu, F; Brillet, A; Chassande-Mottin, E; Cleva, F; Coulon, JP; Dujardin, B; Fournier, JD; Heitmann, H; Man, CN; Spallicci, A; Vinet, JY Measurement of the seismic attenuation performance of the VIRGO Superattenuator ASTROPARTICLE PHYSICS English Article SUSPENSION SYSTEM; INTERFEROMETER; NOISE; SENSITIVITY; SENSOR; BAND The gravitational wave detector VIRGO aims at extending the detection band down to a few Hertz by isolating the mirrors of the interferometer from seismic noise. This result is achieved by hanging each mirror through an elastic suspension (Superattenuator), designed to filter mechanical vibrations in all the degrees of freedom. An experimental upper limit of the mirror residual seismic noise at a few Hertz is provided in this paper. This is lower than the thermal noise floor, expected to limit the antenna sensitivity in the low frequency range. (c) 2005 Elsevier B.V. All rights reserved. Univ Pisa, Sez Pisa Andlor, Ist Nazl Fis Nucl, I-56127 Pisa, Italy; Sez Firenze Urbino, Ist Nazl Fis Nucl, I-50019 Florence, Italy; Univ Florence, I-50125 Florence, Italy; Univ Urbino, I-61029 Urbino, Italy Braccini, S (reprint author), Univ Pisa, Sez Pisa Andlor, Ist Nazl Fis Nucl, Via F Buonarroti 2, I-56127 Pisa, Italy. stefano.braccini@pi.infn.it Gammaitoni, Luca/B-5375-2009; ricciardi, iolanda/D-5527-2009; Acernese, Fausto/E-4989-2010; Freise, Andreas/F-8892-2011; Marchesoni, Fabio/A-1920-2008; Bondu, Francois/A-2071-2012; Cella, Giancarlo/A-9946-2012; Vocca, Helios/F-1444-2010; Punturo, Michele/I-3995-2012; Ferrante, Isidoro/F-1017-2012; Cuoco, Elena/I-8789-2012; Vicere, Andrea/J-1742-2012; Puppo, Paola/J-4250-2012; Rapagnani, Piero/J-4783-2012 Marchesoni, Fabio/0000-0001-6422-2516; Cella, Giancarlo/0000-0002-0752-0338; Punturo, Michele/0000-0001-8722-4485; Puppo, Paola/0000-0003-4677-5015; 23 37 37 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0927-6505 ASTROPART PHYS Astropart Phys. JUL 2005 23 6 557 565 10.1016/j.astropartphys.2005.04.002 9 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 954VZ WOS:000231184600003 J Fontana, M; Amendola, D; Orsini, E; Boffi, A; Pecci, L Fontana, M; Amendola, D; Orsini, E; Boffi, A; Pecci, L Oxidation of hypotaurine and cysteine sulphinic acid by peroxynitrite BIOCHEMICAL JOURNAL English Article cysteine sulphinic acid; hypotaurine; peroxynitrite; reactive sulphur species; sulphonyl radical; taurine HYDROXYL RADICAL FORMATION; NITRIC-OXIDE; CARBON-DIOXIDE; LIPID-PEROXIDATION; ONE-ELECTRON; BIOLOGICAL-ACTIVITY; AQUEOUS-SOLUTION; SINGLET OXYGEN; THIYL RADICALS; AMINO-ACIDS Peroxynitrite mediates the oxidation of the sulphinic group of both HTAU (hypotaurine) and CSA (cysteine sulphinic acid), producing the respective sulphonates, TAU (taurine) and CA (cysteic acid). The reaction is associated with extensive oxygen uptake, suggesting that HTAU and CSA are oxidized by the one-electron transfer mechanism to sulphonyl radicals, which may initiate an oxygen-dependent radical chain reaction with the sulphonates as final products. Besides the one-electron mechanism, HTAU and CSA can be oxidized by the two-electron pathway, leading directly to sulphonate formation without oxygen consumption. The apparent second-order rate constants for the direct reaction of peroxynitrite with HTAU and CSA at pH 7.4 and 25 degrees C are 77.4 +/- 5 and 76.4 +/- 9 M-1.s(-1) respectively. For both sulphinates, the apparent second-order rate constants increase sharply with decrease in pH, and the sigmoidal curves obtained are consistent with peroxynitrous acid as the species responsible for sulphinate oxidation. The kinetic data, together with changes in oxygen uptake, sulphinate depletion, sulphonate production, and product distribution of nitrite and nitrate, suggest that oxidation of sulphinates by peroxynitrite may take place by the two reaction pathways whose relative importance depends on reagent concentrations and pH value. In the presence of bicarbonate, the direct reaction of sulphinates with peroxynitrite is inhibited and the oxidative reaction probably involves only the radicals (NO2)-N-center dot and CO3center dot-, generated by decomposition of the peroxynitrite-CO2 adduct. Univ Roma La Sapienza, CNR, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy; Univ Roma La Sapienza, Inst Mol Biol & Pathol, CNR, I-00185 Rome, Italy Fontana, M (reprint author), Univ Roma La Sapienza, CNR, Dept Biochem Sci A Rossi Fanelli, Piazzale Aldo Moro 5, I-00185 Rome, Italy. mario.fontana@uniroma1.it 68 7 7 PORTLAND PRESS LTD LONDON THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND 0264-6021 BIOCHEM J Biochem. J. JUL 1 2005 389 1 233 240 10.1042/BJ20041696 8 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 944XU WOS:000230465200027 J Bossa, C; Amadei, A; Daidone, I; Anselmi, M; Vallone, B; Brunori, M; Di Nola, A Bossa, C; Amadei, A; Daidone, I; Anselmi, M; Vallone, B; Brunori, M; Di Nola, A Molecular dynamics simulation of sperm whale myoglobin: Effects of mutations and trapped CO on the structure and dynamics of cavities BIOPHYSICAL JOURNAL English Article X-RAY CRYSTALLOGRAPHY; CARBON-MONOXIDE; MUTANT MYOGLOBIN; LIGAND MIGRATION; PROTEIN; MOTIONS; CONSISTENCY; NANOSECOND; DIFFUSION; PATHWAYS The results of extended (80-ns) molecular dynamics simulations of wild-type and YQR triple mutant of sperm whale deoxy myoglobin in water are reported and compared with the results of the simulation of the intermediate(s) obtained by photodissociation of CO in the wild-type protein. The opening/closure of pathways between preexistent cavities is different in the three systems. For the photodissociated state, we previously reported a clear-cut correlation between the opening probability and the presence of the photolyzed CO in the proximity of the passage; here we show that in wild-type deoxy myoglobin, opening is almost random. In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring. In YQR deoxy myoglobin, the mutated Gln(E7)64 is stably H-bonded with the mutated Tyr(B10)29. The essential dynamics analysis unveils a different behavior for the three systems. The motion amplitude is progressively restricted in going from wild-type to YQR deoxy myoglobin and to wild-type myoglobin photoproduct. In all cases, the principal motions involve mainly the same regions, but their directions are different. Analysis of the dynamics of the preexisting cavities indicates large fluctuations and frequent connections with the solvent, in agreement with the earlier hypothesis that some of the ligand may escape from the protein through these pathways. Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, Rome, Italy; Univ Roma La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy Bossa, C (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Piazzale Aldo Moro 5, I-00185 Rome, Italy. cebossa@caspur.it Vallone, Beatrice/F-4174-2012 43 60 62 BIOPHYSICAL SOCIETY BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA 0006-3495 BIOPHYS J Biophys. J. JUL 2005 89 1 465 474 10.1529/biophysj.104.055020 10 Biophysics Biophysics 939ZX WOS:000230114500049 J Amadori, S; Suciu, S; Jehn, U; Stasi, R; Thomas, X; Marie, JP; Muus, P; Lefrere, F; Berneman, Z; Fillet, G; Denzlinger, C; Willemze, R; Leoni, P; Leone, G; Casini, M; Ricciuti, F; Vignetti, M; Beeldens, F; Mandelli, F; De Witte, T Amadori, S; Suciu, S; Jehn, U; Stasi, R; Thomas, X; Marie, JP; Muus, P; Lefrere, F; Berneman, Z; Fillet, G; Denzlinger, C; Willemze, R; Leoni, P; Leone, G; Casini, M; Ricciuti, F; Vignetti, M; Beeldens, F; Mandelli, F; De Witte, T EORTC GIMENA Leukemia Grps Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia final results of AML-13, a randomized phase-3 study BLOOD English Article COLONY-STIMULATING FACTOR; ACUTE MYELOGENOUS LEUKEMIA; PLACEBO-CONTROLLED TRIAL; SOUTHWEST-ONCOLOGY-GROUP; ADULT PATIENTS GREATER-THAN-55; COUNCIL AML11 TRIAL; ELDERLY-PATIENTS; DOUBLE-BLIND; CYTOSINE-ARABINOSIDE; COOPERATIVE GROUP The role of glycosylated recombinant human granulocyte colony-stimulating factor (G-CSF) in the induction treatment of older adults with acute myeloid leukemia (AML) is still uncertain. In this trial, a total of 722 patients with newly diagnosed AML, median age 68 years, were randomized into 4 treatment arms: (A) no G-CSIF; (B) G-CSIF during chemotherapy; (C) G-CSIF after chemotherapy until day 28 or recovery of polymorphonuclear leukocytes; and (D) G-CSIF during and after chemotherapy. The complete remission (CR) rate was 48.9% in group A, 52.2% in group B, 48.3% in group C, and 64.4% in group D. Analysis according to the 2 x 2 factorial design indicated that the CR rate was significantly higher in patients who received G-CSF during chemotherapy (58.3% for groups B + D vs 48.6% for groups A + C; P =.009), whereas no significant difference was observed between groups A + B and C + D (50.6% vs 56.4%, P =.12). In terms of overall survival, no significant differences were observed between the various groups. Patients who received G-CSIF after chemotherapy had a shorter time to neutrophil recovery (median, 20 vs 25 days; P <.001) and a shorter hospitalization (mean, 27.2 vs 29.7 days; P <.001). We conclude that although priming with G-CSF can improve the CR rate, the use of G-CSF during and/or after chemotherapy has no effect on the long-term outcome of AML in older patients. Univ Roma Tor Vergata, Dept Hematol, I-00144 Rome, Italy; Eortc Data Ctr, Brussels, Belgium; Univ Munich, Klinikum Grosshadern, Dept Hematol, D-8000 Munich, Germany; Regina Apostolorum Hosp, Hematol Unit, Albano Laziale, Italy; Hop Edouard Herriot, Dept Hematol, Lyon, France; Hop Hotel Dieu, Dept Hematol, F-75181 Paris, France; Univ Nijmegen, Radboud Med Ctr, Dept Hematol, Nijmegen, Netherlands; Hop Necker Enfants Malad, Dept Hematol, Paris, France; Univ Hosp, Dept Hematol, Edegem, Belgium; Sart Tilman Hosp, Dept Hematol, Liege, Belgium; Univ Tubingen Hosp, Dept Hematol, Tubingen, Germany; Univ Leiden Hosp, Dept Hematol, NL-2300 RC Leiden, Netherlands; Univ Hosp, Dept Hematol, Ancona, Italy; Catholic Univ Rome, Dept Hematol, Rome, Italy; Gen Hosp, Dept Hematol, Bolzano, Italy; San Carlo Hosp, Dept Hematol, Potenza, Italy; GIMEMA, Rome, Italy; Univ Roma La Sapienza, Dept Hematol, Rome, Italy Amadori, S (reprint author), Univ Roma Tor Vergata, St Eugeino Hosp, Dept Hematol, Ple Umanesimo 10, I-00144 Rome, Italy. mc7673@mclink.it 42 85 89 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood JUL 1 2005 106 1 27 34 10.1182/blood-2004-09-3728 8 Hematology Hematology 940PN WOS:000230156500012 J Capria, S; Latagliata, R; Avvisati, G; Breccia, M; Cimino, G; Diverio, D; Petti, MC; Meloni, G Capria, S; Latagliata, R; Avvisati, G; Breccia, M; Cimino, G; Diverio, D; Petti, MC; Meloni, G BAVC regimen and autologous bone marrow transplantation for APL patients in second molecular remission: updated results BONE MARROW TRANSPLANTATION English Letter ACUTE PROMYELOCYTIC LEUKEMIA Univ Roma La Sapienza, Div Hematol, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome, Italy; Univ Campus Biomed, Rome, Italy; Ist Regina Elena, I-00161 Rome, Italy Capria, S (reprint author), Univ Roma La Sapienza, Div Hematol, Dipartimento Biotecnol Cellulari & Ematol, Via Benevento 6, I-00161 Rome, Italy. 5 6 6 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0268-3369 BONE MARROW TRANSPL Bone Marrow Transplant. JUL 2005 36 1 83 84 10.1038/sj.bmt.1704995 2 Biophysics; Oncology; Hematology; Immunology; Transplantation Biophysics; Oncology; Hematology; Immunology; Transplantation 937ID WOS:000229916900011 J Torelli, GF; Guarini, A; Porzia, A; Chiaretti, S; Tatarelli, C; Diverio, D; Maggio, R; Vitale, A; Ritz, J; Foa, R Torelli, GF; Guarini, A; Porzia, A; Chiaretti, S; Tatarelli, C; Diverio, D; Maggio, R; Vitale, A; Ritz, J; Foa, R FLT3 inhibition in t(4;11)+ adult acute lymphoid leukaemia BRITISH JOURNAL OF HAEMATOLOGY English Article FLT3; acute lymphoid leukaemia; targeted therapy; kinase inhibition; signal transduction ACUTE LYMPHOBLASTIC-LEUKEMIA; TYROSINE KINASE INHIBITOR; MINIMAL-RESIDUAL-DISEASE; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA; GENE-EXPRESSION PROFILE; PHASE-I; MUTATIONS; ASSOCIATION; RECEPTOR The present study was designed to investigate, in t(4;11)+ adult lymphoid leukaemia (ALL) blast cells, the pathogenetic role of the FLT3 protein, its level of mRNA and protein expression, the degree of constitutive phosphorylation, the possible presence of mutations of the sequence, the capacity of signal transduction and the potential therapeutic role of specific inhibitors. We evaluated nine adult ALL patients carrying this translocation. The increased FLT3 mRNA levels, determined by oligonucleotide microarray analysis, was in agreement with the increased protein expression evaluated by Western blot. The protein was constitutively phosphorylated in all cases analysed. Polymerase chain reaction detected no internal tandem duplication or point mutations. The signal transduction apparatus, after stimulation with the specific ligand, was preserved. We then investigated the effect of specific FLT3 inhibition on signal transduction and survival. The PKC412 inhibitor specifically inhibited ligand-induced phosphorylation; the same inhibitor reduced the survival of leukaemic cells when compared with untreated cells. These data indicate that the FLT3 protein might play a role in this subgroup of ALL with a particularly poor prognosis. Specific inhibition of the kinase receptor must be hypothesised as an innovative therapeutic tool for t(4;11)+ ALL patients. Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Div Haematol, I-00161 Rome, Italy; Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA Foa, R (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Div Haematol, Via Benevento 6, I-00161 Rome, Italy. rfoa@bce.uniroma1.it Ritz, Jerome/C-7929-2009 Ritz, Jerome/0000-0001-5526-4669 46 14 14 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0007-1048 BRIT J HAEMATOL Br. J. Haematol. JUL 2005 130 1 43 50 10.1111/j.1365-2141.2005.05556.x 8 Hematology Hematology 940AN WOS:000230116200005 J Battaglia, PA; Ponti, D; Naim, V; Venanzi, S; Psaila, R; Gigliani, F Battaglia, PA; Ponti, D; Naim, V; Venanzi, S; Psaila, R; Gigliani, F The HIV-Tat protein induces chromosome number aberrations by affecting mitosis CELL MOTILITY AND THE CYTOSKELETON English Article HIV-Tat-tubulin interaction; chromosome aberrations; Drosophila HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOPLASMIC DYNEIN; DROSOPHILA EMBRYO; CELLS; TRANSDUCTION; CHECKPOINT; IDENTIFICATION; CYTOSKELETON; CENTROSOMES; CENTROMERES To analyze the effects of the HIV-Tat-tubulin interaction, we microinjected HIV-Tat purified protein into Drosophila syncytial embryos. Following the Tat injection, altered timing of the cortical nuclear cycles was observed; specifically, the period between the nuclear envelope breakdown and anaphase initiation was lengthened as was the period between anaphase initiation and the fort-nation of the next nuclear envelope. These two periods correspond to kinetochore alignment at metaphase and to mitosis exit, respectively. We also demonstrated that these two delays are the consequence of damage specifically induced by Tat on kinetochore alignment and on the timing of sister chromatid segregation at anaphase. Furthermore, we show that the expression of Tat in Drosophila larvae brain cells produces a significant percentage of polyploid and aneuploid cells. The results reported here indicate that Tat impairs the mitotic process and that Tat-tubulin interaction appears to be responsible for the observed defects. The presence of polyploid and aneuploid cells is consistent with a delay or arrest in the M phase of a substantial fraction of the cells expressing Tat, suggesting that mitotic spindle checkpoints are overridden following Tat expression. (c) 2005 Wiley-Liss, Inc. Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari Ematol, Policlin Umberto 1, I-00161 Rome, Italy; Ist Super Sanita, Lab Biol Cellulare, I-00161 Rome, Italy Gigliani, F (reprint author), Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari Ematol, Policlin Umberto 1, Viale Regina Elena,324, I-00161 Rome, Italy. gigliani@bce.uniroma1.it 34 4 4 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0886-1544 CELL MOTIL CYTOSKEL Cell Motil. Cytoskeleton JUL 2005 61 3 129 136 10.1002/cm.20070 8 Cell Biology Cell Biology 941DC WOS:000230193900001 J Cacchi, S; Fabrizi, G Cacchi, S; Fabrizi, G Synthesis and functionalization of Indoles through palladium-catalyzed reactions CHEMICAL REVIEWS English Review CROSS-COUPLING REACTIONS; SOLID-PHASE SYNTHESIS; HETEROAROMATIC RING-SYSTEMS; DIRECTED ORTHO-METALATION; CARBON BOND FORMATION; AMINOPALLADATION-REDUCTIVE ELIMINATION; ASSISTED INTRAMOLECULAR AMINATION; ANTITUMOR ANTIBIOTIC CC-1065; PI-ALLYLPALLADIUM COMPLEXES; INHIBITOR CARBAZOQUINOCIN-C Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy Cacchi, S (reprint author), Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, P A Moro 5, I-00185 Rome, Italy. sandro.cacchi@uniroma1.it 416 723 729 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0009-2665 CHEM REV Chem. Rev. JUL 2005 105 7 2873 2920 10.1021/cr040639b 48 Chemistry, Multidisciplinary Chemistry 945SQ WOS:000230522900006 J Campagna, F; Fioretti, F; Burattin, M; Romeo, S; Sentinelli, F; Bifolco, M; Sirinian, MI; Del Ben, M; Angelico, F; Arca, M Campagna, F; Fioretti, F; Burattin, M; Romeo, S; Sentinelli, F; Bifolco, M; Sirinian, MI; Del Ben, M; Angelico, F; Arca, M Congenital analbuminemia attributable to compound heterozygosity for novel mutations in the albumin gene CLINICAL CHEMISTRY English Article SPLICING MUTATION; DIAGNOSIS; FAMILY; RATS Univ Roma La Sapienza, Dept Clin & Appl Med Therapy, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Div Internal Med 4, I-00161 Rome, Italy Arca, M (reprint author), Univ Roma La Sapienza, Policlin Umberto I, Dipartimento Clin & Terapia Med Applicata, Viale Policlin 155, I-00161 Rome, Italy. marcelloarca@libero.it 20 15 15 AMER ASSOC CLINICAL CHEMISTRY WASHINGTON 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA 0009-9147 CLIN CHEM Clin. Chem. JUL 2005 51 7 1256 1258 10.1373/clinchem.2005.048561 3 Medical Laboratory Technology Medical Laboratory Technology 939VS WOS:000230101200025 J Chiesa, C; Osborn, JF; Pacifico, L; Tellan, G; Strappini, PM; Fazio, R; Delogu, G Chiesa, C; Osborn, JF; Pacifico, L; Tellan, G; Strappini, PM; Fazio, R; Delogu, G Circulating ghrelin in patients undergoing elective cholecystectomy CLINICAL CHEMISTRY English Article PLASMA GHRELIN; ACYLATED PEPTIDE; LEPTIN; RESPONSES; HUMANS; RATS Univ Roma La Sapienza, Dept Pediat, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Publ Hlth Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Anesthesia & Intens Care, I-00161 Rome, Italy; CNR, Rome, Italy Chiesa, C (reprint author), Univ Roma La Sapienza, Dept Pediat, Viale Regina Elena 324, I-00161 Rome, Italy. claudio.chiesa@uniroma1.it 20 6 6 AMER ASSOC CLINICAL CHEMISTRY WASHINGTON 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA 0009-9147 CLIN CHEM Clin. Chem. JUL 2005 51 7 1258 1261 10.1373/clinchem.2005.050104 4 Medical Laboratory Technology Medical Laboratory Technology 939VS WOS:000230101200026 J Tabolacci, E; Zollino, M; Lecce, R; Sangiorgi, E; Gurrieri, F; Leuzzi, V; Opitz, JM; Neri, G Tabolacci, E; Zollino, M; Lecce, R; Sangiorgi, E; Gurrieri, F; Leuzzi, V; Opitz, JM; Neri, G Two brothers with 22q13 deletion syndrome and features suggestive of the Clark-Baraitser syndrome CLINICAL DYSMORPHOLOGY English Article 22q13 deletion syndrome; Clark-Baraitser syndrome; X-linked mental retardation; multiple congenital anomalies syndrome; cryptic chromosome rearrangements LINKED MENTAL-RETARDATION; CHROMOSOMAL REARRANGEMENTS; OBESITY; FAMILY; XLMR We report on two brothers with moderate-to-severe mental retardation, severe macrocephaly, obesity, characteristic face, big hands and feet, advanced bone age and brain abnormalities, including frontal cortical atrophy. These two boys resembled the two brothers described by Clark and Baraitser (1987), two maternal cousins subsequently reported by Baraitser et al. (1995) and a Brazilian boy described by de Pina-Neto and Andreotti-de Molfetta (1998). Upon further investigation, we detected a cryptic subtelomeric deletion of chromosome region 22q13, not present in either parent and probably due to a maternal germinal mosaicism. Thus, we describe the first familial case of 22q13 deletion and recommend that patients with a phenotype suggestive of the so-called Clark-Baraitser syndrome be tested for submicroscopic 22qter deletion. Univ Sacred Heart, Inst Med Genet, I-00168 Rome, Italy; Univ Roma La Sapienza, Dept Neurol & Psychiat Sci, Rome, Italy; Univ Utah, Salt Lake City, UT USA Neri, G (reprint author), Univ Sacred Heart, Inst Med Genet, Largo F Vito 1, I-00168 Rome, Italy. gneri@rm.unicatt.it 17 5 6 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0962-8827 CLIN DYSMORPHOL Clin. Dysmorphol. JUL 2005 14 3 127 132 10.1097/00019605-200507000-00004 6 Genetics & Heredity Genetics & Heredity 950PC WOS:000230868400004 J Briganti, G; D'Arrigo, G; Maccarini, M; Pierleoni, C; Sterpone, F Briganti, G; D'Arrigo, G; Maccarini, M; Pierleoni, C; Sterpone, F Hydration and thermodynamic equilibrium of non-ionic surfactant in solution COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS English Article; Proceedings Paper International Workshop on Bubble and Drop Interfaces APR 25-28, 2004 Genoa, ITALY Italian Natl Res Council, Dept Inst energet & Interphase micellar interface; oligooxyethylene glycol; non-ionic surfactant aggregates MICELLAR SOLUTIONS; PHASE-BEHAVIOR; WATER In this article we present a combined analysis of volumetric [1] and molecular dynamics (MD) [2] determinations of the interfacial properties of non-ionic surfactant aggregates belonging to the family of the oligooxyethylene glycol (CiEj). The volumetric experiments were made on surfactant having i = 12 andj ranging from 5 to 8 EO unit and concern the density, and the sound velocity measurements on aqueous solutions of the surfactants. For concentrations up to about 40 wt.% the density of the solutions cross that of pure solvent at given temperatures. The presence of crossing temperatures T-rho allows us to describe the surfactant solutions in terms of an ideal mixture of pure solvent and an effective solute. On the ground of a simple hydration model for the micellar aggregate, we obtained the dependence of the degree of hydration and of the osmotic compressibility on the solute molar volumes and on the temperature. On the other hand, the compressibility embodies a term associated with a local osmotic exchange between the aggregates and the external solvent. To obtain a microscopic resolution of the interfacial properties. MD simulations were performed on a spherical C12E6 micelle. The dependence of the aggregate hydration on the temperature obtained by MD agrees with the results from density experiment. However, the MD clearly indicates that dehydration mainly occurs at the exposed hydrophobic area. Besides the MD results have shown that the micellar interface is characterized by significative interaction among the hydrophilic termination. These interactions leave a large hydrophobic area exposed to the solvent. Despite the complexity of the problem, in the context of our hydration model and within 40 wt.%, the properties of these solutions can be defined by their specific hydration numbers. (c) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, CRS, INFM, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, Dipartimento Energet, I-00185 Rome, Italy; Univ Heidelberg, Angew Phys Chem, D-69120 Heidelberg, Germany; Univ Aquila, INFM, Dipartimento Fis, I-67100 Laquila, Italy; Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA Briganti, G (reprint author), Univ Roma La Sapienza, CRS, INFM, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. giuseppe.briganti@romal.infn.it 16 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0927-7757 COLLOID SURFACE A Colloid Surf. A-Physicochem. Eng. Asp. JUL 1 2005 261 1-3 SI 93 99 10.1016/j.colsurfa.2004.11.037 7 Chemistry, Physical Chemistry 940RL WOS:000230161600011 J Ferri, M; Laghi, A; Mingazzini, P; Iafrate, F; Meli, L; Ricci, F; Passariello, R; Ziparo, V Ferri, M; Laghi, A; Mingazzini, P; Iafrate, F; Meli, L; Ricci, F; Passariello, R; Ziparo, V Pre-operative assessment of extramural invasion and sphincteral involvement in rectal cancer by magnetic resonance imaging with phased-array coil COLORECTAL DISEASE English Article rectal cancer; clinical staging; magnetic resonance inriaging; pre-operative radiotherapy; sphincter-saving surgery TOTAL MESORECTAL EXCISION; LOWER 3RD; CARCINOMA; MR; RADIOTHERAPY; RESECTION; ACCURACY; TOMOGRAPHY; SURGERY; TUMORS Objective: Pre-operative staging of rectal cancer should identify patients with extrarectal spread, who might benefit from pre-operative radiotherapy, and patients with minimal sphincteral involvement, who can avoid permanent colostomy. The aim of this study was to assess the accuracy of Magnetic Resonance Imaging (MRI) to predict turnout stage and sphincter status. Patients and methods: Thirty-three patients with a rectal tumour were pre-operatively assessed by MRI with a phased-array coil. Imaging results were correlated with the final pathological findings. Results: The overall accuracy of pre-operative staging with MRI was 88% (k = 0.75) for extramural tumour invasion and 59% (k = 0.26) for lymph node metastases. MRI correctly evaluated the infiltration of the anal sphincters in 87% of patients (7 of 8 patients with low rectal tumour). Conclusion: MRI provides the surgeon with valuable information regarding extramural tumour spread and sphincteral involvement, enabling appropiate selection of patients for pre-operative adjuvant therapy or sphincter-saving sugery. Univ Roma La Sapienza, Dept Surg P Valdoni, Rome, Italy; Univ Roma La Sapienza, Dept Radiol Sci, Rome, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy Ferri, M (reprint author), Via Cors 4, I-00198 Rome, Italy. mario.ferri@uniroma1.it Laghi, Andrea/A-2343-2011 27 16 16 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1462-8910 COLORECTAL DIS Colorectal Dis. JUL 2005 7 4 387 393 10.1111/j.1463-1318.2005.00787.x 7 Gastroenterology & Hepatology Gastroenterology & Hepatology 975GH WOS:000232648500017 J Gentile, G; Gallavotti, G Gentile, G; Gallavotti, G Degenerate elliptic resonances COMMUNICATIONS IN MATHEMATICAL PHYSICS English Article QUASI-PERIODIC SOLUTIONS; LOWER-DIMENSIONAL TORI; NONLINEAR-WAVE EQUATIONS; INTEGRABLE HAMILTONIAN-SYSTEMS; RENORMALIZATION-GROUP; SCHRODINGER-EQUATION; LINDSTEDT SERIES; INVARIANT TORI; KAM TORI; PERTURBATIONS Quasi-periodic motions on invariant tori of an integrable system of dimension smaller than half the phase space dimension may continue to exist after small perturbations. The parametric equations of the invariant tori can often be computed as a formal power series in the perturbation parameter and can be given a meaning via resummations. Here we prove that, for a class of elliptic tori, a resummation algorithm can be devised and proved to be convergent, thus extending to such lower-dimensional invariant tori the methods employed to prove convergence of the Lindstedt series either for the maximal (i.e. KAM) tori or for the hyperbolic lower-dimensional invariant tori. Univ Roma Tre, Dipartimento Matemat, I-00146 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Gentile, G (reprint author), Univ Roma Tre, Dipartimento Matemat, I-00146 Rome, Italy. Gentile, Guido/G-9383-2012 44 16 16 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0010-3616 COMMUN MATH PHYS Commun. Math. Phys. JUL 2005 257 2 319 362 10.1007/s00220-005-1325-6 44 Physics, Mathematical Physics 927ZN WOS:000229241000006 J Atzeni, S; Schiavi, A; Califano, F; Cattani, F; Cornolti, F; Del Sarto, D; Liseykina, TV; Macchi, A; Pegoraro, F Atzeni, S; Schiavi, A; Califano, F; Cattani, F; Cornolti, F; Del Sarto, D; Liseykina, TV; Macchi, A; Pegoraro, F Fluid and kinetic simulation of inertial confinement fusion plasmas COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Computational Physics SEP 01-04, 2004 Genoa, ITALY inertial confinement fusion (ICF); lagrangian fluid codes; Rayleigh-Taylor instability; laser-plasma interaction; PIC codes; fast ignitor; weibel instability NATIONAL IGNITION FACILITY; LASER FUSION; PROTON-BEAMS; TARGETS; PHYSICS; INSTABILITY; DENSITY; PULSES; SCHEME; FUEL The main features of codes for inertial confinement fusion studies are outlined, and a few recent simulation results are presented. The two-dimensional Lagrangian fluid code DUED is used to study target evolution, including beam-driven compression, hydrodynamic stability, hot spot formation, ignition and burn. An electro-magnetic particle-in-cell (PIC) code is applied to the study of ultraintense laser-plasma interaction and generation of fast electron jets. A relativistic 3D collisionless fluid model addresses relativistic electron beam propagation in a dense plasma. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Energet, Rome, Italy; Univ Pisa, Dipartimento Fis E Fermi, Pisa, Italy; Univ Pisa, INFM, Pisa, Italy Atzeni, S (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Piazzale Aldo Moro 5, Rome, Italy. stefano.atzeni@uniromal.it Macchi, Andrea/B-1900-2009; Liseykina, Tatyana/B-1229-2009; Atzeni, Stefano/F-5538-2012 Macchi, Andrea/0000-0002-1835-2544; 34 33 33 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 153 159 10.1016/j.cpc.2005.03.036 7 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100035 J Sciortino, F; Buldyrev, SV; De Michele, C; Foffi, G; Ghofraniha, N; La Nave, E; Moreno, A; Mossa, S; Saika-Voivod, I; Tartaglia, P; Zaccarelli, E Sciortino, F; Buldyrev, SV; De Michele, C; Foffi, G; Ghofraniha, N; La Nave, E; Moreno, A; Mossa, S; Saika-Voivod, I; Tartaglia, P; Zaccarelli, E Routes to colloidal gel formation COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Computational Physics SEP 01-04, 2004 Genoa, ITALY gels; glasses; colloids POLYMER MIXTURES; PHASE-BEHAVIOR; GLASS-TRANSITION; SYSTEM; DIAGRAMS; MODEL We discuss features of simple inter-particle potentials which are able to generate low-packing fraction arrested states, i.e. gels, in the absence of a macroscopic phase separation phenomenon. We suggest that the ratio between surface and bulk free energy is crucial in favoring ideal gel states. Two possible models for gels, one based on the competition of short range attraction and long range repulsions and the other on local constraints disfavoring packed local structures are discussed. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, CRS, SOFT, I-00185 Rome, Italy; Yeshiva Univ, Dept Phys, New York, NY 10033 USA; European Synchrotron Radiat Facil, F-38043 Grenoble, France; Univ Roma La Sapienza, INFM, CRS, SMC, I-00185 Rome, Italy Sciortino, F (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 5, I-00185 Rome, Italy. francesco.sciortino@phys.uniromal.it Saika-Voivod, Ivan/D-1249-2009; Moreno, Angel/C-7313-2011; Tartaglia, Piero/F-2194-2011; Sciortino, Francesco/B-4768-2012; Foffi, Giuseppe/C-3923-2009; Emanuela, Zaccarelli/K-4695-2013 35 27 27 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 166 171 10.1016/j.cpc.2005.03.038 6 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100037 J Bonella, S; Coker, D Bonella, S; Coker, D Linearized, time-dependent, non-adiabatic quantum correlation functions COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Compuitational Physics SEP 01-04, 2004 Genova, ITALY non-adiabatic dynamics; linearized path integral; mapping Hamiltonian; quantum time correlation functions INITIAL-VALUE REPRESENTATION; VIBRATIONAL-ENERGY RELAXATION; MAPPING HAMILTONIAN APPROACH; COMPLEX MOLECULAR-SYSTEMS; SEMICLASSICAL DESCRIPTION; ELECTRONIC DEGREES; CONDENSED-PHASE; DYNAMICS; EQUATION; FREEDOM A new approximate method for the calculation of quantum time correlation functions is derived. The new theory combines the linearized path integral approach and the mapping Hamiltonian formulation so that time correlation functions can be calculated for systems in which non-adiabatic electronic transitions are important. (c) 2005 Elsevier B.V. All rights reserved. Boston Univ, Dept Chem, Boston, MA 02215 USA Coker, D (reprint author), Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA. sbonella@bu.edu; coker@bu.edu 26 4 4 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 267 273 10.1016/j.cpc.2005.03.061 7 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100059 J Capuzzo-Dolcetta, R Capuzzo-Dolcetta, R High performance computing for self-gravitating systems COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Compuitational Physics SEP 01-04, 2004 Genova, ITALY self-gravitating systems; stellar and galactic systems; supercomputing SOLAR-SYSTEM; SIMULATIONS; EVOLUTION A peculiarity of astrophysics with respect to terrestrial physics is the unavoidable presence of self-gravity. This makes astrophysical simulations very hard to be done, because self-gravity induces, by mean of the fine grain structure superposed to the coarse grain, a multitude of space and time scales. In this report I give (i) a brief overview of the simulation problems to be faced in astrophysics and cosmology, with particular emphasis on the classic gravitational N-body problem and (ii) some results on the evolution of a typical example of intermediate N-body system, like a globular cluster moving in an external galactic field. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy Capuzzo-Dolcetta, R (reprint author), Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy. dolcetta@uniroma1.it 13 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 365 369 10.1016/j.cpc.2005.03.081 5 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100079 J Grimaldi, B; de Raaf, MA; Filetici, P; Ottonello, S; Ballario, P Grimaldi, B; de Raaf, MA; Filetici, P; Ottonello, S; Ballario, P Agrobacterium-mediated gene transfer and enhanced green fluorescent protein visualization in the mycorrhizal ascomycete Tuber borchii: a first step towards truffle genetics CURRENT GENETICS English Article mycorrhizal fungi; Tuber borchii; truffles; Agrobacterium tumefaciens; genetic transformation; EGFP AGARICUS-BISPORUS; NEUROSPORA-CRASSA; HYGROMYCIN-B; TRANSFORMATION; TUMEFACIENS; SEQUENCE; FUNGI; BODY Mycorrhizal ascomycetes are ecologically and commercially important fungi that have proved impervious to genetic transformation so far. We report here on the successful transient transformation of Tuber borchii, an ectomycorrhizal ascomycete that colonizes a variety of trees and produces highly prized hypogeous fruitbodies known as "truffles". A hypervirulent Agrobacterium tumefaciens strain bearing the binary plasmid pBGgHg was used for transformation. The genes for hygromycin resistance and the enhanced green fluorescent protein (EGFP), both under the control of vector-borne promoters, were employed as selection markers. Patches of dark and fluorescent hyphae were observed upon fluorescence microscopic examination of hygromycin-resistant mycelia. The presence of EGFP was confirmed by both confocal microscopy and PCR analysis. The lack in the transformed mycelia of the DNA coding for kanamicin resistance (a trait encoded by a vector-borne gene located outside of the T-DNA region) indicates that Agrobacterium-mediated gene transfer correctly occurred in T. borchii. Univ Roma La Sapienza, Ist Biol & Patol Mol, CNR, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; Avans Hogesch, Dept Life Sci, Breda, Netherlands; Univ Parma, Dipartimento Biochim & Biol Mol, I-43100 Parma, Italy Ballario, P (reprint author), Univ Roma La Sapienza, Ist Biol & Patol Mol, CNR, P Aldo Moro 5, I-00185 Rome, Italy. paola.ballario@uniroma1.it 16 21 24 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0172-8083 CURR GENET Curr. Genet. JUL 2005 48 1 69 74 10.1007/s00294-005-0579-z 6 Genetics & Heredity Genetics & Heredity 947DW WOS:000230624600006 J Laviano, A; Muscaritoli, M; Cascino, A; Preziosa, I; Inui, A; Mantovani, G; Rossi-Fanelli, F Laviano, A; Muscaritoli, M; Cascino, A; Preziosa, I; Inui, A; Mantovani, G; Rossi-Fanelli, F Branched-chain amino acids: the best compromise to achieve anabolism? CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE English Article anorexia; branched-chain amino acids; cachexia; leucine; wasting HYDROXY-BETA-METHYLBUTYRATE; ANOREXIA-CACHEXIA SYNDROME; GASTRIC-CANCER PATIENTS; TUMOR-BEARING RATS; QUALITY-OF-LIFE; SKELETAL-MUSCLE; MEGESTROL-ACETATE; NUTRITIONAL SUPPLEMENTATION; ORAL SUPPLEMENTATION; PARENTERAL-NUTRITION Purpose of review The anorexia-cachexia syndrome is highly prevalent in patients suffering from acute and chronic diseases, including cancer, chronic renal failure and liver cirrhosis. Once it has developed, it significantly influences the clinical course of the underlying disease, simultaneously impinging on patients' quality of life. Unfortunately, currently available therapeutic strategies do not appear to greatly impact on patients' morbidity, mortality and quality of life. More effective therapies are needed to promote appetite and food intake, to preserve lean body mass, and to ameliorate patients' psychological distress. Recent findings Branched-chain amino acids are neutral amino acids with interesting and clinically relevant metabolic effects. Their potential role as antianorexia and anticachexia agents was proposed many years ago, but only recent experimental studies and clinical trials have tested their ability to stimulate food intake and counteract muscle wasting in anorectic, weight-losing patients. By interfering with brain serotonergic activity and by inhibiting the overexpression of critical muscular proteolytic pathways, branched-chain amino acids have been shown to induce beneficial metabolic and clinical effects under different pathological conditions. Summary Based on the available data, branched-chain amino acids appear to exert significant antianorectic and anticachectic effects, and their supplementation may represent a viable intervention not only for patients suffering from chronic diseases, but also for those individuals at risk of sarcopenia due to age, immobility or prolonged bed rest, including trauma, orthopedic or neurologic patients. Univ Roma La Sapienza, Dept Clin Med, I-00185 Rome, Italy; Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Behav Med, Kagoshima 890, Japan; Univ Cagliari, Dept Med Oncol, Cagliari, Italy Laviano, A (reprint author), Univ Roma La Sapienza, Dept Clin Med, Viale Univ 37, I-00185 Rome, Italy. alessandro.laviano@uniroma1.it 48 40 42 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA 1363-1950 CURR OPIN CLIN NUTR Curr. Opin. Clin. Nutr. Metab. Care JUL 2005 8 4 408 414 10.1097/01.mco.0000172581.79266.19 7 Endocrinology & Metabolism; Nutrition & Dietetics Endocrinology & Metabolism; Nutrition & Dietetics 976IZ WOS:000232728200011 J de Angelis, L; Zhao, JH; Andreucci, JJ; Olson, EN; Cossu, G; McDermott, JC de Angelis, L; Zhao, JH; Andreucci, JJ; Olson, EN; Cossu, G; McDermott, JC Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway DEVELOPMENTAL BIOLOGY English Article p38 MAPK; MEF2; muscle regulatory factors TRANSCRIPTION FACTOR MEF2; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; GENE-EXPRESSION; MOUSE EMBRYOGENESIS; PARAXIAL MESODERM; MYOGENIN GENE; CELL-GROWTH; MYF-5; DIFFERENTIATION Biochemical and cell culture studies have characterized the myocyte enhancer factor 2 (MEF2) transcriptional regulatory proteins as obligatory partners for the myogenic regulatory factors (MRFs) in the differentiation of myogenic cells in culture. However, the role of MEF2 activation in somitic myogenesis has not been fully characterized. Here, we report a critical interaction between the p38 mitogen-activated protein kinase (p38 MAPK) and MEF2 in the developing somite myotome. We document expression of MEF2A and p38 MAPK proteins in the somite of 9.5 dpc mouse embryos concurrent with Myf 5 protein expression. We also observed that abrogation of p38 MAPK signaling blocks MEF2 activation using a MEF2 transgenic 'sensor' mouse. Inhibition of p38 MAPK signaling concurrently inhibited myogenic differentiation in somite cultures and in embryos in vivo using transplacental injection of a p38 inhibitor (SB203580). Finally, we document that commitment to the myogenic lineage is not appreciably affected by p38 MAPK inhibition since the activation of an early marker of myogenic commitment (Myf 5) occurs normally when p38 MAPK signaling is inhibited. Thus, we present novel evidence indicating a crucial role for p38 MAPK signaling to the MEF2 transcriptional regulators during early mammalian somite development and myotome formation. (C) 2005 Elsevier Inc. All rights reserved. York Univ, Dept Biol, N York, ON M3J 1P3, Canada; Univ Roma La Sapienza, Ist Istol & Embriol Gen, I-00161 Rome, Italy; Univ Texas, SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA; DIBITH San Raffaele, Stem Cell Res Inst, I-20132 Milan, Italy McDermott, JC (reprint author), York Univ, Dept Biol, 4700 Keele St, N York, ON M3J 1P3, Canada. jmcderm@yorku.ca 56 45 47 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0012-1606 DEV BIOL Dev. Biol. JUL 1 2005 283 1 171 179 10.1016/j.ydbio.2005.04.009 9 Developmental Biology Developmental Biology 944HR WOS:000230418400013 J Ishii, H; Mimori, K; Mori, M; Vecchione, A Ishii, H; Mimori, K; Mori, M; Vecchione, A Differentially expressed genes in endothelial differentiation DNA AND CELL BIOLOGY English Article IDENTIFICATION; ANGIOGENESIS; CANCER; LOCALIZATION; BLADDER; RING3 By screening differentially expressed genes in mouse embryonic stem (ES) cells by subtractive hybridization, we identified three conserved but uncharacterized genes encoding bromodomain containing 3 (BRD3), protein lysine methyltransferase (PLM), and kelch domain containing 2 (KLHDC2), which were downregulated during endothelial differentiation. An RNA blot study showed that these genes were markedly expressed in undifferentiated ES cells, whereas the expression was reduced upon endothelial differentiation; a study of mouse endothelium showed a significant reduction in the expression of BRD3. A study of human BRD3, located on chromosome 9 at q34, a region susceptible to genomic rearrangement, showed an altered expression in 4 of 12 patients with bladder cancer, compared with adjacent noncancerous tissues. Taken together with the result of siRNA inhibition showing the positive regulation of cell proliferation by BRD3, it is suggested that this molecule plays a role in allowing cells to enter the proliferative phase of the angiogenic process. Jichi Med Sch, Ctr Mol Med, Minami Kawachi, Tochigi 3290498, Japan; Kyushu Univ, Inst Bioregulat, Ohita, Japan; Univ Roma La Sapienza, Fac Med 2, Hosp Santo Andrea, Div Pathol, Rome, Italy Ishii, H (reprint author), Jichi Med Sch, Ctr Mol Med, Minami Kawachi, Tochigi 3290498, Japan. hishii@ms.jichi.ac.jp 16 2 5 MARY ANN LIEBERT INC NEW ROCHELLE 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA 1044-5498 DNA CELL BIOL DNA Cell Biol. JUL 2005 24 7 432 437 10.1089/dna.2005.24.432 6 Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity 946QD WOS:000230586300003 J D'Amelio, R; Mele, A; Mariano, A; Romano, L; Biselli, R; Lista, F; Zanetti, A; Stroffollini, T D'Amelio, R; Mele, A; Mariano, A; Romano, L; Biselli, R; Lista, F; Zanetti, A; Stroffollini, T Hepatitis A, Italy EMERGING INFECTIOUS DISEASES English Letter Univ Roma La Sapienza, Osped S Andrea, Fac Med & Chirurg 2, I-00189 Rome, Italy; Direz Gen Sanite Mil, Rome, Italy; Ist Super Sanita, I-00161 Rome, Italy; Univ Milan, Ist Virol, Milan, Italy; Ctr Sperimentale Volo, Pratica Di Mare, Italy; Ctr Studie & Ric Sanita & Vet, Rome, Italy; Osped S Giacomo, Rome, Italy D'Amelio, R (reprint author), Univ Roma La Sapienza, Osped S Andrea, Fac Med & Chirurg 2, Via Grottarossa 1039, I-00189 Rome, Italy. raffaele.damelio@ospedalesantandrea.it 6 12 12 CENTER DISEASE CONTROL ATLANTA ATLANTA, GA 30333 USA 1080-6040 EMERG INFECT DIS Emerg. Infect. Dis JUL 2005 11 7 1155 1156 2 Immunology; Infectious Diseases Immunology; Infectious Diseases 939XS WOS:000230106600041 J Sciubba, E; Ulgiati, S Sciubba, E; Ulgiati, S Emergy and exergy analyses: Complementary methods or irreducible ideological options? ENERGY English Article The paper discusses the similarities and the incompatibilities between two forms of Energy Analysis (exergy and emergy, 'EXA' and 'EMA' in the following), both of which try to represent the behavior of physical systems by means of cumulative energy input/output methods that result in a double integration over space and. time domains. Theoretical background, definitions and balance algebra are discussed first, in a 'statement-counterstatement' format that helps pinpointing differences and similarities. A significant, albeit simplified, benchmark case (ethanol production from corn) is used to compare the results and analytically assess the merits of each approach as well as possible synergic aspects. Corn production, transport and industrial conversion to ethanol are included in the analysis. First, mass balance and energy accounting are performed in each step of the process, then, exergy and emergy evaluations are carried out separately to lead to a set of performance indicators, the meaning of which is discussed with reference to their proper scale of application. The Authors underline that each method has its own preferred field of application and conclude that the two approaches appear to be characterized not much as different (and therefore 'competing) tools, but as different paradigms, whose meta-levels (their 'philosophies') substantially differ. In particular, EXA is found to provide the most correct and insightful assessment of thermodynamic features of any process and to offer a clear quantitative indication of both the irreversibilities and the degree of matching between the used resources and the end-use material or energy flows. EXA combined with costing considerations results in Thermo-Economics (TE), presently the best engineering method for System optimization. One of EXA recent extensions, Extended Exergy Accounting (EEA) includes all externalities in the exergy resource accounting, thus providing a more complete picture of how a process is interacting with its socio-economical environment and with the Biosphere. EMA further expands the evaluation to the larger scale of the Biosphere and properly accounts for the globality of the energy and resource flows supporting complex living systems. Although some conceptual assumptions and methodological differences appear irreconcilable, important similarities are also found that may lead to further methodological and practical convergences. Note: Although a significant confrontation and debate accompanied the development of this paper, contrasting opinions about important features of the two approaches still exist. Therefore, SU takes full responsibility of statements in Sections 2,4.1, 6.2, 7.1 while ES takes full responsibility of statements in Sections 3,4.2, 6.1, 7.2. All remaining Sections reflect points of view agreed upon by both Authors. &COPY; 2004 Elsevier Ltd. All rights reserved. Univ Rome 1, Dept Mech & Aeronaut Engn, I-00184 Rome, Italy; Univ Siena, Dept Chem, I-53100 Siena, Italy Sciubba, E (reprint author), Univ Rome 1, Dept Mech & Aeronaut Engn, Via Eudossiana 18, I-00184 Rome, Italy. enrico.sciubba@uniroma1.it 65 81 85 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0360-5442 ENERGY Energy JUL 2005 30 10 1953 1988 10.1016/j.energy.2004.08.003 36 Thermodynamics; Energy & Fuels Thermodynamics; Energy & Fuels 927BQ WOS:000229167800019 J Tomei, MC; Annesini, MC Tomei, MC; Annesini, MC 4-mitrophenol biodegradation in a sequencing batch reactor operating with aerobic-anoxic cycles ENVIRONMENTAL SCIENCE & TECHNOLOGY English Article P-NITROPHENOL; 4-NITROPHENOL BIODEGRADATION; DEGRADATION; REMOVAL; KINETICS; MODEL The study regards 4-nitrophenol removal performed in a lab-scale sequential batch reactor with an integrated aerobic-anoxic cycle. The purpose of the study was to examine the kinetics of 4-nitrophenol biological oxidation and denitrification in order to test the feasibility of the proposed technological solution for xenobiotic removal. The results obtained showthat high removal efficiency of 4-nitrophenol is easily achieved when the compound is fed into the reactor as the sole carbon source. Residual concentrations of 4-nitrophenol and nitrous/nitric nitrogen in the effluent lower than 1 mg L-1 were observed in the range of applied feed concentration (200-320 mg L-1). Low concentrations of dissolved oxygen (<= 2 mg L-1) in the feed and aerobic phases lead to appreciable simultaneous denitrification. As regards the denitrification process, while no carbon limiting effects were observed at COD/N ratios >= 3, a significant decrease in the rate of denitrification is detected for COD/N ratios <= 2. The denitrification rate obtained in tests with no external carbon addition proved very low and unsuitable for practical application. A model of the denitrification process taking into account both the limiting effect of nitrogen and carbonaceous substrate has been proposed and applied for experimental data correlation. CNR, Water Res Inst, I-00198 Rome, Italy; Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy Tomei, MC (reprint author), CNR, Water Res Inst, Via Reno 1, I-00198 Rome, Italy. tomei@irsa.cnr.it 21 30 30 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0013-936X ENVIRON SCI TECHNOL Environ. Sci. Technol. JUL 1 2005 39 13 5059 5065 10.1021/es0483140 7 Engineering, Environmental; Environmental Sciences Engineering; Environmental Sciences & Ecology 941WS WOS:000230245500061 J Di Bonaventura, C; Vaudano, AE; Carni, M; Pantano, P; Nucciarelli, V; Garreffa, G; Maraviglia, B; Prencipe, M; Bozzao, L; Manfredi, M; Giallonardo, AT Di Bonaventura, C; Vaudano, AE; Carni, M; Pantano, P; Nucciarelli, V; Garreffa, G; Maraviglia, B; Prencipe, M; Bozzao, L; Manfredi, M; Giallonardo, AT Long-term reproducibility of fMRI activation in epilepsy patients with fixation off sensitivity EPILEPSIA English Letter EEG Univ Roma La Sapienza, Dept Neurol Sci, Epilepsy Unit, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy; Univ Roma La Sapienza, Neuromed Inst Pozzilli, I-00185 Rome, Italy; Enrico Fermi Ctr, Rome, Italy Di Bonaventura, C (reprint author), Univ Roma La Sapienza, Dept Neurol Sci, Epilepsy Unit, Viale Univ 30, I-00185 Rome, Italy. c_dibonaventura@yahoo.it Patrizia, Pantano/C-8214-2009; Garreffa, Girolamo/F-4204-2010 Garreffa, Girolamo/0000-0002-2678-6692 9 10 10 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0013-9580 EPILEPSIA Epilepsia JUL 2005 46 7 1149 1151 10.1111/j.1528-1167.2005.11005.x 3 Clinical Neurology Neurosciences & Neurology 944LZ WOS:000230431800022 J Quaglione, R; Calcagnini, G; Censi, F; Malavasi, M; Raveggi, M; Biancalana, G; Bartolini, P; Critelli, G Quaglione, R; Calcagnini, G; Censi, F; Malavasi, M; Raveggi, M; Biancalana, G; Bartolini, P; Critelli, G Effect of pacemaker rate-adaptation on 24h beat-to-beat heart rate and blood pressure profiles EUROPACE English Article heart rate; blood pressure; rate-responsive pacing SYMPATHETIC-NERVE ACTIVITY; CLOSED-LOOP STIMULATION; INTRACARDIAC IMPEDANCE; SINGLE-CHAMBER; VVI; VARIABILITY; BENEFIT; SIGNAL; BLIND Aims The aims of the study were to evaluate the 24-h beat-to-beat heart rate (RR) and blood pressure changes during closed loop stimulation (DDDCLS) pacing and conventional fixed rate DDD pacing with respect to spontaneous activity. Methods We simultaneously and continuously measured beat-to-beat heart rate and blood pressure for 24 h in patients implanted with Inos(2+) (Biotronik GmbH, Berlin, Germany). A randomised cross-over comparison of DDD-CLS and DDD pacing was performed by short- and long-term analyses. Results Seventeen patients (10 mates, aged 46-85 years) were enroled in the study: 11 completed the protocol. The percentage of atrial stimulation was 72.87% during DDD-CLS and 38.36% in DDD (P = 0.003). All patients were 100% stimulated in the ventricle. On average, the percentage increase of paced RR intervals with respect to spontaneous beats was only 7.4% in DDD-CLS but 20.1% in DDD (P = 0.0001). A significant correlation between spontaneous and paced RR profiles was obtained only during DDD-CLS (r(DDD-CLS) = 0.77, r(DDD) = 0.23, P = 0.01). Shortterm analysis revealed a 3.79% reduction of the escape interval in DDD-CLS and 8.19% in DDD, and the relative fall in diastolic blood pressure was 1.14% in DDD-CLS and 3.81% in DDD. Conclusion DDD-CLS provided physiological heart rate fluctuations throughout the 24-h test. The blood pressure profiles of paced and spontaneous beats were comparable. The onset of paced rhythm in DDD-CLS resulted in a less pronounced decrease in heart rate and fall in diastolic pressure than in DDD. (c) 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved. Ist Super Sanita, Dept Technol & Hlth, I-00161 Rome, Italy; Univ Roma La Sapienza, Inst Heart & Great Vessels, Rome, Italy; Biotron Seda, Milan, Italy Calcagnini, G (reprint author), Ist Super Sanita, Dept Technol & Hlth, Viale Regina Elena 299, I-00161 Rome, Italy. giovanni.calagnini@iss.it 23 7 7 W B SAUNDERS CO LTD LONDON 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND 1099-5129 EUROPACE Europace JUL 2005 7 4 366 373 10.1016/j.eupc.2005.03.005 8 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 941YX WOS:000230251200008 J Marchetti, DJ; Nucci, F Marchetti, DJ; Nucci, F Price stickiness and the contractionary effect of technology shocks EUROPEAN ECONOMIC REVIEW English Article technology shocks; price stickiness; business cycle MONETARY-POLICY RULES; BUSINESS-CYCLE; PANEL-DATA; ESTIMATORS; SCALE; SPECIFICATION; REGRESSIONS; EMPLOYMENT; RETURNS; OUTPUT We derive a measure of technological change from a dynamic cost minimization model that controls for imperfect competition, increasing returns and unobserved factor utilization. We estimate this measure using highly detailed panel data of a representative sample of Italian manufacturing firms for the period 1984-1997. Our key finding is that technological improvements result in a contraction of labor input on impact. In principle, this result can be reconciled with the transmission mechanism of flexible-price models by resorting to reorganization and reallocation effects. On the other hand, however, it is consistent with the predictions of a sticky-price model. Using survey information on the frequency of price revisions, we corroborate the latter interpretation, by showing that the contractionary effect of technology shocks is much stronger for firms with stickier prices. (c) 2003 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Fac Sci Stat, I-00185 Rome, Italy; Bank Italy, Dept Res, I-00184 Rome, Italy Nucci, F (reprint author), Univ Roma La Sapienza, Fac Sci Stat, Ple A Moro 5, I-00185 Rome, Italy. francesco.nucci@uniroma1.it 37 12 12 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0014-2921 EUR ECON REV Eur. Econ. Rev. JUL 2005 49 5 1137 1163 10.1016/j.euroecorev.2003.08.012 27 Economics Business & Economics 929QL WOS:000229360700004 J Abbate, A; Biondi-Zoccai, GGL Abbate, A; Biondi-Zoccai, GGL The difficult task of glycaemic control in diabetics with acute coronary syndromes: finding the way to normoglycaemia avoiding both hyper- and hypoglycaemia EUROPEAN HEART JOURNAL English Editorial Material ACUTE MYOCARDIAL-INFARCTION; STRESS HYPERGLYCEMIA; GLUCOSE; INSULIN; APOPTOSIS; MORTALITY; ISCHEMIA; MELLITUS; RISK Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23233 USA; Univ Hosp St Rafael, Intervent Cardiol Unit, Milan, Italy Abbate, A (reprint author), Virginia Commonwealth Univ, Dept Internal Med, 10025 Bellona Court, Richmond, VA 23233 USA. abbatea@yahoo.com Abbate, Antonio/C-2388-2008 15 6 6 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0195-668X EUR HEART J Eur. Heart J. JUL 2005 26 13 1245 1248 10.1093/eurheartj/ehi230 4 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 943WD WOS:000230384700001 J Breccia, M; D'Andrea, M; Alimena, G Breccia, M; D'Andrea, M; Alimena, G Can nifedipine and estrogen interaction with imatinib be responsible for gallbladder stone development? EUROPEAN JOURNAL OF HAEMATOLOGY English Letter Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy Breccia, M (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Via Benevento 6, Rome, Italy. breccia@bce.uniroma1.it 4 2 2 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0902-4441 EUR J HAEMATOL Eur. J. Haematol. JUL 2005 75 1 89 90 10.1111/j.1600-0609.2005.00476.x 2 Hematology Hematology 932VE WOS:000229581400016 J Wood, ET; Stover, DA; Ehret, C; Destro-Bisol, GD; Spedini, G; McLeod, H; Louie, L; Bamshad, M; Strassmann, BI; Soodyall, H; Hammer, MF Wood, ET; Stover, DA; Ehret, C; Destro-Bisol, GD; Spedini, G; McLeod, H; Louie, L; Bamshad, M; Strassmann, BI; Soodyall, H; Hammer, MF Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes EUROPEAN JOURNAL OF HUMAN GENETICS English Article mtDNA; Y chromosome; human; Africa; language; geography; correlation; evolution; Mantel SUB-SAHARAN AFRICA; HUMAN-POPULATIONS; HAPLOTYPES; AFFINITIES; ORIGINS; MITOCHONDRIAL; DIVERSITY; MIGRATION; EUROPE; POLYMORPHISMS To investigate associations between genetic, linguistic, and geographic variation in Africa, we type 50 Y chromosome SNPs in 1122 individuals from 40 populations representing African geographic and linguistic diversity. We compare these patterns of variation with those that emerge from a similar analysis of published mtDNA HVS1 sequences from 1918 individuals from 39 African populations. For the Y chromosome, Mantel tests reveal a strong partial correlation between genetic and linguistic distances (r = 0.33, P = 0.001) and no correlation between genetic and geographic distances ( r = -0.08, P > 0.10). In contrast, mtDNA variation is weakly correlated with both language (r = 0.16, P = 0.046) and geography (r = 0.17, P = 0.035). AMOVA indicates that the amount of paternal among-group variation is much higher when populations are grouped by linguistics (Phi(CT) = 0.21) than by geography (Phi(CT) = 0.06). Levels of maternal genetic among-group variation are low for both linguistics and geography (Phi(CT) = 0.03 and 0.04, respectively). When Bantu speakers are removed from these analyses, the correlation with linguistic variation disappears for the Y chromosome and strengthens for mtDNA. These data suggest that patterns of differentiation and gene flow in Africa have differed for men and women in the recent evolutionary past. We infer that sex-biased rates of admixture and/or language borrowing between expanding Bantu farmers and local hunter-gatherers played an important role in influencing patterns of genetic variation during the spread of African agriculture in the last 4000 years. Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA; Univ Arizona, Div Biotechnol, Tucson, AZ 85721 USA; Univ Calif Los Angeles, Dept Hist, Los Angeles, CA 90024 USA; Univ Roma La Sapienza, Dept Anim & Human Biol, Rome, Italy; Washington Univ, Dept Med, St Louis, MO USA; Childrens Hosp Oakland, Oakland, CA 94609 USA; Univ Utah, Salt Lake City, UT USA; Univ Michigan, Dept Anthropol, Ann Arbor, MI 48109 USA; Univ Witwatersrand, Human Genom Divers & Dis Res Unit, Johannesburg, South Africa Hammer, MF (reprint author), Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA. mfh@u.arizona.edu 47 93 94 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 1018-4813 EUR J HUM GENET Eur. J. Hum. Genet. JUL 2005 13 7 867 876 10.1038/sj.ejhg.5201408 10 Biochemistry & Molecular Biology; Genetics & Heredity Biochemistry & Molecular Biology; Genetics & Heredity 938CJ WOS:000229977200013 J Chekanov, S; Derrick, M; Magill, S; Miglioranzi, S; Musgrave, B; Repond, J; Yoshida, R; Mattingly, MCK; Pavel, N; Yagues, AG; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romeo, GC; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Margotti, A; Montanari, A; Nania, R; Palmonari, F; Pesci, A; Polini, A; Rinaldi, L; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Irrgang, P; Jakob, HP; Kind, OM; Meyer, U; Paul, E; Rautenberg, J; Renner, R; Voss, KC; Wang, M; Wlasenko, M; Bailey, DS; Brook, NH; Cole, JE; Heath, GP; Namsoo, T; Robins, S; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, JY; Ma, KJ; Helbich, M; Ning, Y; Ren, Z; Schmidke, WB; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Szuba, D; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Kowal, AM; Lukasik, J; Przybycien, M; Suszycki, L; Szuba, J; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Borras, K; Drews, G; Fourletova, J; Geiser, A; Gladkov, D; Gottlicher, PG; Gutsche, O; Haas, T; Hain, W; Horn, C; Kahle, B; Kotz, U; Kowalski, H; Kramberger, G; Lelas, D; Lim, H; Lohr, B; Mankel, R; Melzer-Pellman, IA; Nguyen, CN; Notz, D; Nuncio-Quiroz, AE; Raval, A; Santamarta, R; Schneekloth, U; Stadie, H; Stosslein, U; Wolf, G; Youngman, C; Zeuner, W; Schlenstedt, S; Barbagli, G; Gallo, E; Genta, C; Pelfer, PG; Bamberger, A; Benen, A; Karstens, F; Dobur, D; Vlasov, NN; Bussey, PJ; Doyle, AT; Dunne, W; Ferrando, J; Hamilton, J; Saxon, DH; Skillicorn, IO; Gialas, I; Carli, T; Gosau, T; Holm, U; Krumnack, N; Lohrmann, E; Milite, M; Salehi, H; Schleper, P; Schorner-Sadenius, T; Stonjek, S; Wichmann, K; Wick, K; Ziegler, A; Ziegler, A; Collins-Tooth, C; Foudas, C; Fry, C; Goncalo, R; Long, KR; Tapper, AD; Kataoka, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, AN; Boos, EG; Pokrovskiy, NS; Zhautykov, BO; Son, D; de Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jimenez, M; Labarga, L; del Peso, J; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Plamondon, M; Robichaud-Veronneau, A; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, BA; Rubinsky, I; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, RK; Ermolov, PF; Gladilin, LK; Katkov, II; Khein, LA; Korzhavina, IA; Kuzmin, VA; Levchenko, BB; Lukina, OY; Proskuryakov, AS; Shcheglova, LM; Zotkin, DS; Zotkin, SA; Abt, I; Buttner, C; Caldwell, A; Liu, X; Sutiak, J; Coppola, N; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Maddox, E; Tiecke, H; Vazquez, M; Wiggers, L; Brummer, N; Bylsma, B; Durkin, LS; Ling, TY; Allfrey, PD; Bell, MA; Sarkar, AMC; Cottrell, A; Devenish, RCE; Foster, B; Gwenlan, C; Kohno, T; Gorzo, KK; Patel, S; Straub, PB; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Ciesielski, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Heaphy, EA; Metlica, F; Oh, BY; Whitmore, JJ; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Hart, JC; Abramowicz, H; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Kuze, M; Kagawa, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Matsuzawa, K; Ota, O; Ri, YD; Costa, M; Ferrero, MI; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, JF; Butterworth, JM; Hall-Wilton, R; Jones, TW; Loizides, JH; Sutton, MR; Targett-Adams, C; Wing, M; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, RJ; Pawlak, JM; Sztuk, J; Tymieniecka, T; Tyszkiewicz, A; Ukleja, A; Ukleja, J; Zarnecki, AF; Adamus, M; Plucinski, P; Eisenberg, Y; Hochman, D; Karshon, U; Lightwood, MS; Brownson, E; Danielson, T; Everett, A; Kcira, D; Lammers, S; Li, L; Reeder, DD; Rosin, M; Ryan, P; Savin, AA; Smith, WH; Dhawan, S; Bhadra, S; Catterall, CD; Cui, Y; Hartner, G; Menary, S; Noor, U; Soares, M; Standage, J; Whyte, J Chekanov, S; Derrick, M; Magill, S; Miglioranzi, S; Musgrave, B; Repond, J; Yoshida, R; Mattingly, MCK; Pavel, N; Yagues, AG; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romeo, GC; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Margotti, A; Montanari, A; Nania, R; Palmonari, F; Pesci, A; Polini, A; Rinaldi, L; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Irrgang, P; Jakob, HP; Kind, OM; Meyer, U; Paul, E; Rautenberg, J; Renner, R; Voss, KC; Wang, M; Wlasenko, M; Bailey, DS; Brook, NH; Cole, JE; Heath, GP; Namsoo, T; Robins, S; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, JY; Ma, KJ; Helbich, M; Ning, Y; Ren, Z; Schmidke, WB; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Szuba, D; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Kowal, AM; Lukasik, J; Przybycien, M; Suszycki, L; Szuba, J; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Borras, K; Drews, G; Fourletova, J; Geiser, A; Gladkov, D; Gottlicher, PG; Gutsche, O; Haas, T; Hain, W; Horn, C; Kahle, B; Kotz, U; Kowalski, H; Kramberger, G; Lelas, D; Lim, H; Lohr, B; Mankel, R; Melzer-Pellman, IA; Nguyen, CN; Notz, D; Nuncio-Quiroz, AE; Raval, A; Santamarta, R; Schneekloth, U; Stadie, H; Stosslein, U; Wolf, G; Youngman, C; Zeuner, W; Schlenstedt, S; Barbagli, G; Gallo, E; Genta, C; Pelfer, PG; Bamberger, A; Benen, A; Karstens, F; Dobur, D; Vlasov, NN; Bussey, PJ; Doyle, AT; Dunne, W; Ferrando, J; Hamilton, J; Saxon, DH; Skillicorn, IO; Gialas, I; Carli, T; Gosau, T; Holm, U; Krumnack, N; Lohrmann, E; Milite, M; Salehi, H; Schleper, P; Schorner-Sadenius, T; Stonjek, S; Wichmann, K; Wick, K; Ziegler, A; Ziegler, A; Collins-Tooth, C; Foudas, C; Fry, C; Goncalo, R; Long, KR; Tapper, AD; Kataoka, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, AN; Boos, EG; Pokrovskiy, NS; Zhautykov, BO; Son, D; de Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jimenez, M; Labarga, L; del Peso, J; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Plamondon, M; Robichaud-Veronneau, A; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, BA; Rubinsky, I; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, RK; Ermolov, PF; Gladilin, LK; Katkov, II; Khein, LA; Korzhavina, IA; Kuzmin, VA; Levchenko, BB; Lukina, OY; Proskuryakov, AS; Shcheglova, LM; Zotkin, DS; Zotkin, SA; Abt, I; Buttner, C; Caldwell, A; Liu, X; Sutiak, J; Coppola, N; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Maddox, E; Tiecke, H; Vazquez, M; Wiggers, L; Brummer, N; Bylsma, B; Durkin, LS; Ling, TY; Allfrey, PD; Bell, MA; Sarkar, AMC; Cottrell, A; Devenish, RCE; Foster, B; Gwenlan, C; Kohno, T; Gorzo, KK; Patel, S; Straub, PB; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Ciesielski, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Heaphy, EA; Metlica, F; Oh, BY; Whitmore, JJ; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Hart, JC; Abramowicz, H; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Kuze, M; Kagawa, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Matsuzawa, K; Ota, O; Ri, YD; Costa, M; Ferrero, MI; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, JF; Butterworth, JM; Hall-Wilton, R; Jones, TW; Loizides, JH; Sutton, MR; Targett-Adams, C; Wing, M; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, RJ; Pawlak, JM; Sztuk, J; Tymieniecka, T; Tyszkiewicz, A; Ukleja, A; Ukleja, J; Zarnecki, AF; Adamus, M; Plucinski, P; Eisenberg, Y; Hochman, D; Karshon, U; Lightwood, MS; Brownson, E; Danielson, T; Everett, A; Kcira, D; Lammers, S; Li, L; Reeder, DD; Rosin, M; Ryan, P; Savin, AA; Smith, WH; Dhawan, S; Bhadra, S; Catterall, CD; Cui, Y; Hartner, G; Menary, S; Noor, U; Soares, M; Standage, J; Whyte, J ZEUS Collaboration An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment EUROPEAN PHYSICAL JOURNAL C English Article DEEP-INELASTIC SCATTERING; PARTON DISTRIBUTIONS; PERTURBATION-THEORY; E(+)P SCATTERING; LEADING-ORDER; EP SCATTERING; HERA; ALPHA(S); PHOTOPRODUCTION; PHOTON The ZEUS inclusive differential cross-section data from HERA, for charged and neutral current processes taken with e(+) and e(-) beams, together with differential cross-section data on inclusive jet production in e+ p scattering and dijet production in gamma p scattering, have been used in a new NLO QCD analysis to extract the parton distribution functions of the proton. The input of jet-production data constrains the gluon and allows an accurate extraction of alpha(s)( M(Z)) at NLO; alpha(s)( M(Z)) = 0.1183 +/- 0.0028( exp.) +/- 0.0008( model). An additional uncertainty from the choice of scales is estimated as +/- 0.005. This is the first extraction of as( M(Z)) from HERA data alone. Argonne Natl Lab, Argonne, IL 60439 USA; Andrews Univ, Berrien Springs, MI 49104 USA; Humboldt Univ, Inst Phys, Berlin, Germany; Univ Bologna, Bologna, Italy; Ist Nazl Fis Nucl, I-40126 Bologna, Italy; Univ Bonn, Inst Phys, D-5300 Bonn, Germany; Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England; Univ Calabria, Dept Phys, I-87036 Cosenza, Italy; Ist Nazl Fis Nucl, I-87036 Cosenza, Italy; Chonnam Natl Univ, Kwangju 500757, South Korea; Columbia Univ, Nevis Labs, New York, NY 10027 USA; Inst Nucl Phys, Krakow, Poland; AGH Univ Sci & Technol, Fac Phys & Appl Com Sci, Krakow, Poland; Jagiellonian Univ, Dept Phys, Krakow, Poland; DESY, D-2000 Hamburg, Germany; DESY, Zeuthen, Germany; Univ Florence, Florence, Italy; Ist Nazl Fis Nucl, I-50125 Florence, Italy; Univ Freiburg, Fak Phys, D-7800 Freiburg, Germany; Univ Glasgow, Dept Phys & Astron, Glasgow, Lanark, Scotland; Univ Hamburg, Inst Phys Expt, Hamburg, Germany; Univ London Imperial Coll Sci Technol & Med, High Energy Nucl Phys Grp, London, England; Natl Lab High Energy Phys, KEK, Inst Particle & Nucl Studies, Tsukuba, Ibaraki 305, Japan; Minist Educ & Sci Kazakhstan, Inst Phys & Technol, Alma Ata, Kazakhstan; Kyungpook Natl Univ, Ctr High Energy Phys, Taegu 702701, South Korea; Univ Catholique Louvain, Inst Nucl Phys, B-1348 Louvain, Belgium; Univ Autonoma Madrid, Dept Fis Teor, Madrid, Spain; McGill Univ, Dept Phys, Montreal, PQ H3A 2T8, Canada; Meiji Gakuin Univ, Fac Gen Educ, Yokohama, Kanagawa, Japan; Moscow Engn Phys Inst, Moscow 115409, Russia; Moscow MV Lomonosov State Univ, Inst Nucl Phys, Moscow, Russia; Max Planck Inst Phys & Astrophys, D-80805 Munich, Germany; NIKHEF, Amsterdam, Netherlands; Univ Amsterdam, Amsterdam, Netherlands; Ohio State Univ, Dept Phys, Columbus, OH 43210 USA; Univ Oxford, Dept Phys, Oxford, England; Univ Padua, Dept Fis, Padua, Italy; Ist Nazl Fis Nucl, Padua, Italy; Penn State Univ, Dept Phys, University Pk, PA 16802 USA; Polytech Univ, Sagamihara, Kanagawa, Japan; Univ Roma La Sapienza, Dipartimento Fis, Rome, Italy; Ist Nazl Fis Nucl, Rome, Italy; Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Phys, IL-69978 Tel Aviv, Israel; Tokyo Inst Technol, Dept Phys, Tokyo 152, Japan; Univ Tokyo, Dept Phys, Tokyo 113, Japan; Tokyo Metropolitan Univ, Dept Phys, Tokyo 158, Japan; Univ Turin, Turin, Italy; Ist Nazl Fis Nucl, I-10125 Turin, Italy; Univ Piemonte Orientale, Novara, Italy; Ist Nazl Fis Nucl, I-10125 Turin, Italy; Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; UCL, Dept Phys & Astron, London, England; Warsaw Univ, Inst Expt Phys, Warsaw, Poland; Inst Nucl Studies, PL-00681 Warsaw, Poland; Weizmann Inst Sci, Dept Particle Phys, IL-76100 Rehovot, Israel; Univ Wisconsin, Dept Phys, Madison, WI 53706 USA; Yale Univ, Dept Phys, New Haven, CT 06520 USA; York Univ, Dept Phys, N York, ON M3J 1P3, Canada; UCL, London, England; Max Planck Inst, Munich, Germany Chekanov, S (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. De Pasquale, Salvatore/B-9165-2008; Wing, Matthew/C-2169-2008; Fazio, Salvatore /G-5156-2010; Doyle, Anthony/C-5889-2009; collins-tooth, christopher/A-9201-2012; Ferrando, James/A-9192-2012; Gladilin, Leonid/B-5226-2011; Levchenko, B./D-9752-2012; Proskuryakov, Alexander/J-6166-2012; Dementiev, Roman/K-7201-2012 Ferrando, James/0000-0002-1007-7816; Gladilin, Leonid/0000-0001-9422-8636; 49 102 102 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1434-6044 EUR PHYS J C Eur. Phys. J. C JUL 2005 42 1 1 16 10.1140/epjc/s2005-02293-x 16 Physics, Particles & Fields Physics 953ZK WOS:000231123700001 J Limatola, C; Di Bartolomeo, S; Catalano, M; Trettel, F; Fucile, S; Castellani, L; Eusebi, F Limatola, C; Di Bartolomeo, S; Catalano, M; Trettel, F; Fucile, S; Castellani, L; Eusebi, F Cysteine residues are critical for chemokine receptor CXCR2 functional properties EXPERIMENTAL CELL RESEARCH English Article CXCR2; cysteines; chemotaxis; signal transduction; receptor dimerization PROTEIN-COUPLED RECEPTORS; CELL-SURFACE EXPRESSION; SIGNAL-TRANSDUCTION; LIGAND-BINDING; HEK CELLS; DIMERIZATION; NEURONS; INTERNALIZATION; INTERLEUKIN-8; ROLES We examined the role of cysteine (Cys) residues present in chemokine receptor CXCR2 for proper surface expression, dimerization, signaling, and chemotaxis. To address this issue, serine or leucine residues were substituted for Cys, generating nine CXCR2 mutants transiently expressed in HEK cells. Single substitution of Cys residues present in the three extracellular loops (C119L, C196L, C286S) or in the seventh-transmembrane (TM) domain (C308L) abolished CXCL8 agonist binding, while no Cys substitution abolished surface receptor expression. We have previously demonstrated that CXCR2 dimerizes under reducing conditions, due to hydrophobic interactions that involve TM3 regions, and here we show that the dimer/monomer CXCR2 ratio drastically increases when analyzed under non-reducing conditions. We report that none of the Cys-deficient CXCR2 mutants abolishes receptor dimerization, demonstrating that Cys-Cys bonds are not the exclusive determinant of CXCR2 dimerization. Furthermore, both wt- and Cys-mutated CXCR2 dimers are expressed at the cell surface, indicating that receptor dimers are efficiently transferred at the plasma membrane. We also show that every Cys substitution in CXCR2, including those that still bind CXCL8, results in an impairment of receptor activity, analyzed as cell chemotaxis and intracellular signaling, suggesting that some structural requirement is likely fulfilled by Cys presence. (c) 2005 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Ist Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, Ctr Eccellenza BEMM, I-00185 Rome, Italy; Neuromed IRCCS, I-186077 Isernia, Italy; Univ Cassino, Dipartimento Sci Mororie & Salute, I-03043 Cassino, Italy; Fdn Santa Lucia, I-00179 Rome, Italy Limatola, C (reprint author), Citta Univ, Ist Fisiol Umana, Piazzale Aldo Moro 5, I-00185 Rome, Italy. cristina.limatola@uniroma1.it Fucile, Sergio/B-3934-2010 Fucile, Sergio/0000-0003-0698-1148 32 8 8 ELSEVIER INC SAN DIEGO 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495, UNITED STATES 0014-4827 EXP CELL RES Exp. Cell Res. JUL 1 2005 307 1 65 75 10.1016/j.yexer.2005.02.020 11 Oncology; Cell Biology Oncology; Cell Biology 934QJ WOS:000229723000006 J Kricka, LJ; Park, JY; Li, SFY; Fortina, P Kricka, LJ; Park, JY; Li, SFY; Fortina, P Miniaturized detection technology in molecular diagnostics EXPERT REVIEW OF MOLECULAR DIAGNOSTICS English Review carbon nanotube; electrochemical detection; microchip CE; multiplexing; nanoparticles; nanopore; nanotechnology; non-PCR testing POLYMERASE-CHAIN-REACTION; GOLD NANOPARTICLE PROBES; SOLID-STATE NANOPORE; HEPATITIS-C VIRUS; MICROCHIP ELECTROPHORESIS; DNA HYBRIDIZATION; CAPILLARY-ELECTROPHORESIS; GENOMIC DNA; ELECTROCHEMICAL DETECTION; HETERODUPLEX ANALYSIS Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection. Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore; Thomas Jefferson Univ, Ctr Translat Med, Philadelphia, PA 19107 USA; Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy Kricka, LJ (reprint author), Univ Penn, Sch Med, Dept Pathol & Lab Med, 7-103 Founders Pavilion,3400 Spruce St, Philadelphia, PA 19104 USA. kricka@mail.med.upenn.edu; jason_park@uphs.upenn.edu; chmlifys@nus.edu.sg; paolo.forting@jefferson.edu Li, Sam/J-3113-2013 Li, Sam/0000-0002-2092-9226 94 15 16 FUTURE DRUGS LTD LONDON UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEYY CENTRAL, LONDON N3 1QB, ENGLAND 1473-7159 EXPERT REV MOL DIAGN Expert Rev. Mol. Diagn. JUL 2005 5 4 549 559 10.1586/14737159.5.4.549 11 Pathology Pathology 943WH WOS:000230385100010 J Gharbiya, M; Grandinetti, F; Gabrieli, CB Gharbiya, M; Grandinetti, F; Gabrieli, CB Intravitreal triamcinolone for macular detachment following panretinal photocoagulation EYE English Letter EDEMA; ACETONIDE Univ Roma La Sapienza, Dept Ophthalmol, I-00161 Rome, Italy Gharbiya, M (reprint author), Univ Roma La Sapienza, Dept Ophthalmol, Vle Policlin 155, I-00161 Rome, Italy. magda.gharbiya@tiscali.it 6 4 4 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0950-222X EYE Eye JUL 2005 19 7 818 820 10.1038/sj.eye.6701658 4 Ophthalmology Ophthalmology 942TA WOS:000230304100028 J Centorrino, F; Fogarty, KV; Sani, G; Salvatore, P; Cimbolli, P; Baldessarini, RJ Centorrino, F; Fogarty, KV; Sani, G; Salvatore, P; Cimbolli, P; Baldessarini, RJ Antipsychotic drug use: McLean Hospital, 2002 HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL English Article antipsychotic; inpatient; polypharmacy; olanzapine; antipsychotic dosing; prescribing pattern Objective Major changes in antipsychotic treatment in recent years encouraged a survey of inpatient practice in 2002, compared with earlier samples. Methods Based on records of a random sample of McLean Hospital inpatients prescribed antipsychotics in 2002, the study recorded DSM-IV discharge diagnosis, all psychotropic treatments and doses, initial, peak and final doses of all antipsychotics, clinical status at admission and discharge, and adverse effects reported. Results were compared with similar data from our earlier surveys. Results Subjects were 344 inpatients (n = 202 women, 59%), diagnosed with psychotic (n = 102, 30%), bipolar (n = 93, 27%), major depressive (n = 67, 19.5%), dementia (n = 19, 5.5%), substance-use (n = 28, 8%) or other psychiatric disorders (n = 35, 10%). Second-generation antipsychotics accounted for 88% of antipsychotic prescriptions; 17% of patients received >= 2 antipsychotics and total CPZ-eq discharge does in 2002 averaged 291 +/- 305 mg/day (22% less than a 1998 peak). Doses were unrelated to age, but higher in men, among psychotic vs major affective disorder patients, and with greater illness-severity and longer hospitalization. There was a 3.3-fold increase in the simultaneous use of >= 3 psychotropic agents since 1998. Conclusions The use of second-generation antipsychotics dominates current inpatient practice. Total antipsychotic dosing has not increased recently, but the use of multiple psychotropics increased strikingly from 1998 to 2002. Copyright (C) 2005 John Wiley & Sons, Ltd. McLean Hosp, Schizophrenia & Bipolar Disorder Clin, Schizophrenia & Bipolar Disorder Program, Belmont, MA 02478 USA; Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA; Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA; McLean Hosp, Psychopharmacol Program, Belmont, MA 02478 USA Centorrino, F (reprint author), McLean Hosp, Schizophrenia & Bipolar Disorder Clin, Schizophrenia & Bipolar Disorder Program, N Belknap 3,115 Mill St, Belmont, MA 02478 USA. centorf@mcleanpo.mclean.org 7 12 12 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0885-6222 HUM PSYCHOPHARM CLIN Hum. Psychopharmacol.-Clin. Exp. JUL 2005 20 5 355 358 10.1002/hup.700 4 Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology 951ZG WOS:000230970300006 J Bianco, L; Cimini, D; Marzano, FS; Ware, R Bianco, L; Cimini, D; Marzano, FS; Ware, R Combining microwave radiometer and wind profiler radar measurements for high-resolution atmospheric humidity profiling JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY English Article CLOUD LIQUID; WATER-VAPOR; BOUNDARY-LAYER; TEMPERATURE; GRADIENTS; CONTAMINATION; TURBULENCE; RETRIEVAL; SYSTEM A self-consistent remote sensing physical method to retrieve atmospheric humidity high-resolution profiles by synergetic use of a microwave radiometer profiler (N/lWRP) and wind profiler radar (WPR) is illustrated. The proposed technique is based on the processing of WPR data for estimating the potential refractivity gradient profiles and their optimal combination with MWRP estimates of potential temperature profiles in order to fully retrieve humidity gradient profiles. The combined algorithm makes use of recent developments in WPR signal processing, computing the zeroth-, first-, and second-order moments of WPR Doppler spectra via a fuzzy logic method, which provides quality control of radar data in the spectral domain. On the other hand, the application of neural network to brightness temperatures, measured by a multichannel MWRP, can provide continuous estimates of tropospheric temperature and humidity profiles. Performance of the combined algorithm in retrieving humidity profiles is compared with simultaneous in situ radiosonde observations (raob's). The empirical sets of WPR and MWRP data were collected at the Atmospheric Radiation Measurement (ARM) Program's Southern Great Plains (SGP) site. Combined microwave radiometer and wind profiler measurements show encouraging results and significantly improve the spatial vertical resolution of atmospheric humidity profiles. Finally, some of the limitations found in the use of this technique and possible future improvements are also discussed. Univ Aquila, Dipartimento Fis & Atmosfera, CETEMPS, Ctr Excellence, I-67010 Coppito, Italy; Univ Colorado, NOAA, Environm Technol Lab, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA Bianco, L (reprint author), Univ Aquila, Dipartimento Fis & Atmosfera, CETEMPS, Ctr Excellence, Via Vetoio, I-67010 Coppito, Italy. Laura.Bianco@aquila.infn.it 33 11 11 AMER METEOROLOGICAL SOC BOSTON 45 BEACON ST, BOSTON, MA 02108-3693 USA 0739-0572 J ATMOS OCEAN TECH J. Atmos. Ocean. Technol. JUL 2005 22 7 949 965 10.1175/JTECH1771.1 17 Engineering, Ocean; Meteorology & Atmospheric Sciences Engineering; Meteorology & Atmospheric Sciences 960MA WOS:000231595500012 J Grimaldi, L; De Giorgio, F; Masullo, M; Zoccai, GB; Martinotti, G; Rainio, J Grimaldi, L; De Giorgio, F; Masullo, M; Zoccai, GB; Martinotti, G; Rainio, J Suicide by pencil JOURNAL OF FORENSIC SCIENCES English Article forensic science; suicide; chest wound; pencil wound; cardiac injury FEATURES We report an unusual suicide, committed with a common pencil. A 72-year-old male inflicted himself a penetrating thoracic wound while being hospitalized for a hip prosthesis operation. Although the patient was immediately operated, the cardiac injury appeared to be fatal. Cases of suicidal penetrating wounds of the anterior chest wall are rare and they are mostly inflicted by knives, glass fragments, or other sharp instruments. The potential danger of a pencil should be taken into consideration, especially in psychiatric hospitals and imprisonment facilities. We examined the legislation in Italy and Finland concerning the regulation of privacy in special care institutions. Univ Sacred Heart, Sch Med, Inst Legal Med, I-00168 Rome, Italy; Univ Sacred Heart, Inst Cardiol, I-00168 Rome, Italy; Univ Sacred Heart, Inst Psychiat, I-00168 Rome, Italy De Giorgio, F (reprint author), Univ Sacred Heart, Sch Med, Inst Legal Med, Largo F Vito,1, I-00168 Rome, Italy. fdegiorgio@tiscalinet.it 6 1 1 AMER SOC TESTING MATERIALS W CONSHOHOCKEN 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA 0022-1198 J FORENSIC SCI J. Forensic Sci. JUL 2005 50 4 913 914 2 Medicine, Legal Legal Medicine 939GY WOS:000230061800025 J Tari, Z; Broberg, J; Zomaya, AY; Baldoni, R Tari, Z; Broberg, J; Zomaya, AY; Baldoni, R A least flow-time first load sharing approach for distributed server farm JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING English Article scheduling policies; task assignment; heavy-tailed workloads; load balancing; load sharing SYSTEMS The most critical property exhibited by a heavy-tailed workload distribution (found in many WWW workloads) is that a very small fraction of tasks make up a large fraction of the workload, making the load very difficult to distribute in a distributed system. Load balancing and load sharing are the two predominant load distribution strategies used in such systems. Load sharing generally has better response time than load balancing because the latter can exhibit excessive overheads in selecting servers and partitioning tasks. We therefore further explored the least-loaded-first (LLF) load sharing approach and found two important limitations: (a) LLF does not consider the order of processing, and (b) when it assigns a task, LLF does not consider the processing capacity of servers. The high task size variation that exists in heavy-tailed workloads often causes smaller tasks to be severely delayed by large tasks. This paper proposes a size-based approach, called the least flow-time first (LFF-SIZE), which reduces the delay caused by size variation while maintaining a balanced load in the system. LFF-SIZE takes the relative processing time of a task into account and dynamically assigns a task to the fittest server with a lighter load and higher processing capacity. LFF-SIZE also uses a multi-section queue to separate larger tasks from smaller ones. This arrangement effectively reduces the delay of smaller tasks by larger ones as small tasks are given a higher priority to be processed. The performance results performed on the LFF-SIZE implementation shows a substantial improvement over existing load sharing and static size-based approaches under realistic heavy-tailed workloads. (c) 2005 Elsevier Inc. All rights reserved. RMIT Univ, Melbourne, Vic, Australia; Univ Sydney, Sydney, NSW 2006, Australia; Univ Rome, Rome, Italy Zomaya, AY (reprint author), RMIT Univ, Melbourne, Vic, Australia. zomaya@it.usyd.edu.au 17 8 8 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0743-7315 J PARALLEL DISTR COM J. Parallel Distrib. Comput. JUL 2005 65 7 832 842 10.1016/j.jpdc.2005.02.007 11 Computer Science, Theory & Methods Computer Science 935CH WOS:000229756300004 J Franceschini, G; Geffert, V Franceschini, G; Geffert, V An in-place sorting with O (n log n) comparisons and O(n) moves JOURNAL OF THE ACM English Article algorithms; sorting in-place MINIMUM DATA MOVEMENT; HEAPSORT We present the first in-place algorithm for sorting an array of size n that performs, in the worst case, at most 0 (n log n) element comparisons and 0 (n) element transports. This solves a long-standing open problem, stated explicitly, for example, in Munro and Raman 1992], of whether there exists a sorting algorithm that matches the asymptotic lower bounds on all computational resources simultaneously. Univ Pisa, Dept Informat, I-56127 Pisa, Italy; Safarik Univ, Kosice, Slovakia Franceschini, G (reprint author), Univ Pisa, Dept Informat, Largo B Pontecorvo 3, I-56127 Pisa, Italy. francesc@di.unipi.it; geffert@upjs.sk 19 6 7 ASSOC COMPUTING MACHINERY NEW YORK 1515 BROADWAY, NEW YORK, NY 10036 USA 0004-5411 J ACM J. ACM JUL 2005 52 4 515 537 10.1145/1082036.1082037 23 Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods Computer Science 966KV WOS:000232019500001 J Aloisio, A; Ambrosino, F; Antonelli, A; Antonelli, M; Bacci, C; Barva, M; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocci, V; Bossi, F; Branchini, P; Bulychjov, SA; Caloi, R; Campana, P; Capon, G; Capussela, T; Carboni, G; Ceradini, F; Cervelli, F; Cevenini, F; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Erriquez, O; Farilla, A; Felici, G; Ferrari, A; Ferrer, ML; Finocchiaro, G; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Lu, F; Martemianov, M; Martini, M; Matsyuk, M; Mei, W; Merola, L; Messi, R; Miscetti, S; Moulson, M; Muller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passalacqua, L; Passeri, A; Patera, V; Perfetto, F; Petrolo, E; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Schamberger, RD; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A; Spadaro, T; Spiriti, E; Tabidze, M; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, S; Ventura, A; Versaci, R; Villella, I; Xu, G; Leone, D Aloisio, A; Ambrosino, F; Antonelli, A; Antonelli, M; Bacci, C; Barva, M; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocci, V; Bossi, F; Branchini, P; Bulychjov, SA; Caloi, R; Campana, P; Capon, G; Capussela, T; Carboni, G; Ceradini, F; Cervelli, F; Cevenini, F; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Erriquez, O; Farilla, A; Felici, G; Ferrari, A; Ferrer, ML; Finocchiaro, G; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Lu, F; Martemianov, M; Martini, M; Matsyuk, M; Mei, W; Merola, L; Messi, R; Miscetti, S; Moulson, M; Muller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passalacqua, L; Passeri, A; Patera, V; Perfetto, F; Petrolo, E; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Schamberger, RD; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A; Spadaro, T; Spiriti, E; Tabidze, M; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, S; Ventura, A; Versaci, R; Villella, I; Xu, G; Leone, D The hadronic cross section measurement at KLOE NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper 8th International Workshop on Tau Lepton Physics SEP 14-17, 2004 Nara, JAPAN TO-LEADING ORDER; RADIATIVE RETURN; E(+)E(-) ANNIHILATION; MAGNETIC-MOMENT; TAGGED PHOTONS; MUON; FACTORIES; CMD-2; NLO KLOE uses the radiative return to measure cross section sigma(e(+) e(-) -> pi(+) pi(-) gamma) at the electron-positron collider DA Phi NE. Divinding by a theoretical radiator function, we obtain the cross section sigma(e(+) e(-) -> pi(+) pi(-)) for the mass range 0.35 < s(pi) < 0.95 GeV2. We calculate the hadronic contribution to the muon anomaly for the given mass range: a(mu) = 388.7 +/- 0.8(stat) +/- 3.5syst +/- 3.5(th). Univ Karlsruhe, Inst Expt Kernphys, D-76021 Karlsruhe, Germany; Univ Lecce Sezione, INFN, Lecce, Italy Aloisio, A (reprint author), Univ Karlsruhe, Inst Expt Kernphys, Postfach 3640, D-76021 Karlsruhe, Germany. valente, paolo/A-6640-2010; Di Domenico, Antonio/G-6301-2011; De Lucia, Erika/D-2250-2011; branchini, paolo/A-4857-2011; Murtas, Fabrizio/B-5729-2012; De Santis, Antonio/J-1453-2012; Veneziano, Stefano/J-1610-2012; Di Micco, Biagio/J-1755-2012; de Simone, Patrizia/J-3549-2012; Gauzzi, Paolo/D-2615-2009 valente, paolo/0000-0002-5413-0068; De Lucia, Erika/0000-0003-0793-0844; De Santis, Antonio/0000-0002-8613-8128; Veneziano, Stefano/0000-0002-2598-2659; 18 3 3 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. JUL 2005 144 231 237 10.1016/j.nuclphysbps.2005.02.032 7 Physics, Particles & Fields Physics 925LQ WOS:000229055000033 J Ruffini, R; Bernardini, MG; Bianco, CL; Chardonnet, P; Fraschetti, F; Gurzadyan, V; Lattanzi, M; Vitagliano, L; Xue, SS Ruffini, R; Bernardini, MG; Bianco, CL; Chardonnet, P; Fraschetti, F; Gurzadyan, V; Lattanzi, M; Vitagliano, L; Xue, SS Extracting energy from black holes: "Long" and "short" GRBs and their astrophysical settings NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA C-GEOPHYSICS AND SPACE PHYSICS English Article; Proceedings Paper 4th Workshop on Gamma-Ray Bursts in the Afterglow Era OCT 18-22, 2004 Rome, ITALY GAMMA-RAY BURSTS; NEUTRON-STARS; GRAVITATIONAL COLLAPSE; LOW-LUMINOSITY; TRANSFORMATIONS; EQUILIBRIUM; ATMOSPHERES; SPECTRA; PHYSICS; PLASMA The introduction of the three interpretational paradigms for Gamma-Ray Bursts (GRBs) and recent progress in understanding the X- and gamma-ray luminosity in the afterglow allow us to make assessments about the astrophysical settings of GRBs. In particular, we evidence the distinct possibility that some GRBs occur in a, binary system. This subclass of GRBs manifests itself in a tryptich": one component formed by the collapse of a massive star to a black hole. which originates the GRB; a second component by a supernova and a third one by a young neutron star born in the supernova event. Similarly. the understanding of the physics of quantum relativistic processes during the gravitational collapse makes possible precise predictions about the structure of short GRBs.

Interobserver reliability of rheumatologists performing musculoskeletal ultrasonography: results from a EULAR ''Train the trainers'' course / A. K., Scheel; W. A., Schmidt; K. G. A., Hermann; G. A., Bruyn; M. A., D'Agostino; W., Grassi; Iagnocco, Annamaria; J. M., Koski; K. P., Machold; E., Naredo; H., Sattler; N., Swen; M., Szkudlarek; R. J., Wakefield; H. R., Ziswiler; D., Pasewaldt; C., Werner; M., Backhaus. - In: IL NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. C, GEOPHYSICS AND SPACE PHYSICS. - ISSN 1124-1896. - STAMPA. - 28:7(2005), pp. 589-596. [10.1136/ard.2004.030387]

Interobserver reliability of rheumatologists performing musculoskeletal ultrasonography: results from a EULAR ''Train the trainers'' course

A. K. Scheel;W. A. Schmidt;K. G. A. Hermann;G. A. Bruyn;M. A. D'Agostino;W. Grassi;IAGNOCCO, Annamaria;J. M. Koski;K. P. Machold;E. Naredo;H. Sattler;N. Swen;M. Szkudlarek;R. J. Wakefield;H. R. Ziswiler;D. Pasewaldt;C. Werner;M. Backhaus

2005

Abstract

Objective: To evaluate the interobserver reliability among 14 experts in musculoskeletal ultrasonography ( US) and to determine the overall agreement about the US results compared with magnetic resonance imaging (MRI), which served as the imaging "gold standard''. Methods: The clinically dominant joint regions ( shoulder, knee, ankle/toe, wrist/finger) of four patients with inflammatory rheumatic diseases were ultrasonographically examined by 14 experts. US results were compared with MRI. Overall agreements, sensitivities, specificities, and interobserver reliabilities were assessed. Results: Taking an agreement in US examination of 10 out of 14 experts into account, the overall kappa for all examined joints was 0.76. Calculations for each joint region showed high kappa values for the knee ( 1), moderate values for the shoulder ( 0.76) and hand/finger (0.59), and low agreement for ankle/toe joints (0.28). kappa Values for bone lesions, bursitis, and tendon tears were high (kappa = 1). Relatively good agreement for most US findings, compared with MRI, was found for the shoulder ( overall agreement 81%, sensitivity 76%, specificity 89%) and knee joint ( overall agreement 88%, sensitivity 91%, specificity 88%). Sensitivities were lower for wrist/finger ( overall agreement 73%, sensitivity 66%, specificity 88%) and ankle/toe joints ( overall agreement 82%, sensitivity 61%, specificity 92%). Conclusion: Interobserver reliabilities, sensitivities, and specificities in comparison with MRI were moderate to good. Further standardisation of US scanning techniques and definitions of different pathological US lesions are necessary to increase the interobserver agreement in musculoskeletal US. Univ Gottingen, Dept Nephrol & Rheumatol, D-3400 Gottingen, Germany; Med Ctr Rheumatol Berlin Buch, Berlin, Germany; Charite Univ Hosp, Dept Radiol, Berlin, Germany; Med Centrum Leeuwarden, Dept Rheumatol, Leeuwarden, Netherlands; UVSQ Univ, Ambroise Pare Hosp, Dept Rheumatol, Boulogne Billancourt, France; Univ Ancona, Osped A Murri, Dept Rheumatol, Ancona, Italy; Univ Roma La Sapienza, Dept Rheumatol, Rome, Italy; Mikkeli Cent Hosp, Dept Rheumatol, Mikkeli, Finland; Univ Vienna, Vienna Gen Hosp, Dept Rheumatol, A-1010 Vienna, Austria; Severo Ochoa Hosp, Dept Rheumatol, Res Unit, Madrid, Spain; Severo Ochoa Hosp, Epidemiol Unit, Madrid, Spain; Parkklin, Dept Rheumatol, Bad Durkheim, Germany; Med Centrum Alkmaar, Dept Rheumatol, Alkmaar, Netherlands; Univ Copenhagen, Hvidovre Hosp, Dept Rheumatol, DK-1168 Copenhagen, Denmark; Leeds Gen Hosp, Acad Dept Musculoskeletal Med, Leeds, W Yorkshire, England; Inselspital Bern, Dept Rheumatol & Clin Immunol, CH-3010 Bern, Switzerland; Univ Gottingen, Dept Med Stat, D-3400 Gottingen, Germany; Charite Univ Hosp, Dept Rheumatol & Clin Immunol, Berlin, Germany Scheel, AK (reprint author), Dept Med Nephrol & Rheumatol, Robert Koch Str 40, D-37075 Gottingen, Germany. ascheel@gwdg.de 28 93 93 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0003-4967 ANN RHEUM DIS Ann. Rheum. Dis. JUL 2005 64 7 1043 1049 10.1136/ard.2004.030387 7 Rheumatology Rheumatology 935YF WOS:000229818600013 J Navia, JL; Atik, FA; Marullo, A; Starling, RC; Garcia, M; Vega, PR; Smedira, NG; McCarthy, PM Navia, JL; Atik, FA; Marullo, A; Starling, RC; Garcia, M; Vega, PR; Smedira, NG; McCarthy, PM Bench repair of donor aortic valve with minimal access orthotopic heart transplantation ANNALS OF THORACIC SURGERY English Article While the number of people waiting heart transplantation increases, the number of organ donors decreases. This shrinking donor pool has prompted reassessment of donor selection for heart transplantation. Bench repair of a donor aortic valve was performed before minimal access orthotopic heart transplantation. Aortic insufficiency in the structurally normal tricuspid aortic valve was due to annular dilatation and was corrected with subcommissural annular plication. The postoperative period was uneventful. Follow-up at 4.5 years showed good results and no evidence of aortic regurgitation. (c) 2005 by The Society of Thoracic Surgeons. Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, Cleveland, OH 44195 USA Navia, JL (reprint author), Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, Desk F-25,9500 Euclid Ave, Cleveland, OH 44195 USA. naviaj@ccf.org 10 5 5 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0003-4975 ANN THORAC SURG Ann. Thorac. Surg. JUL 2005 80 1 313 315 10.1016/j.athoracsur.2004.01.030 3 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 941LG WOS:000230215700051 J D'Andrilli, A; Ibrahim, M; Venuta, F; De Giacomo, T; Coloni, F; Rendina, EA D'Andrilli, A; Ibrahim, M; Venuta, F; De Giacomo, T; Coloni, F; Rendina, EA Glutaraldehyde preserved autologous pericardium for patch reconstruction of the pulmonary artery and superior vena cava ANNALS OF THORACIC SURGERY English Editorial Material LUNG-CANCER; RESECTION We describe a new employment of glutaraldehyde preserved autologous pericardium for patch reconstruction of the pulmonary artery (PA) and superior vena cava (SVC). This technique was devised to minimize technical problems related to the use of fresh pericardium such as excessive elasticity and tendency to curl. We have successfully employed this procedure in three cases of reconstruction of the PA and in two cases of reconstruction of the SVC. (c) 2005 by The Society of Thoracic Surgeons. St Andrea Hosp, Div Thorac Surg, I-00161 Rome, Italy; Univ Roma La Sapienza, Policlin Umberto I, Rome, Italy Rendina, EA (reprint author), St Andrea Hosp, Div Thorac Surg, Via Grottarossa 1035, I-00161 Rome, Italy. erinoangelo.rendina@tin.it 6 13 13 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0003-4975 ANN THORAC SURG Ann. Thorac. Surg. JUL 2005 80 1 357 358 10.1016/j.athoracsur.2004.02.012 2 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 941LG WOS:000230215700073 J Tombolini, V; Raffetto, N; Santarelli, M; Valeriani, M; Necozione, S; Masedu, F; Enrici, RM Tombolini, V; Raffetto, N; Santarelli, M; Valeriani, M; Necozione, S; Masedu, F; Enrici, RM Carcinoma of the vulva: Clinical results of exclusive and adjuvant radiotherapy ANTICANCER RESEARCH English Article vulvar cancer; exclusive radiotherapy; adjuvant radiotherapy; surgery SQUAMOUS-CELL CARCINOMA; GYNECOLOGIC-ONCOLOGY-GROUP; PROGNOSTIC FACTORS; CANCER; MANAGEMENT; RADIATION; CHEMORADIATION; CHEMOTHERAPY; RECURRENCE; SURGERY Background: The aim of this study was to evaluate the historical cohort of 61 patients with carcinoma of the vulva, treated with radiation therapy from 1986 to 1997 Patients and Methods: Twenty-seven patients were submitted to radiation therapy alone and 34 received radiotherapy post limited surgery in early stages and post radical vulvectomy in advanced stages. The dose range varied from 59 to 63 Gy in post-operative patients and 65 Gy to 71 Gy in curative patients. Results: Five-year Overall Survival (OS) and Disease-Free Survival (DFS) for patients treated with irradiation alone and for those treated with post-operative radiotherapy were 50.8% and 69.7%, respectively, without significant statistical difference. For OS multivariate analysis showed statistical difference for stage and age variables, and for stage variable in the case of DFS. Conclusion: In early stage vulvar cancer patients OS and DFS are good, with high control rate and low incidence of adverse effect. In loco-regionally-advanced patients, especially in those with stage IV or with > 2 positive lymph nodes, the outcomes are poor. Osped S Salvatore, UO Radioterapia, Dept Expt Med, I-67100 Laquila, Italy; Univ Roma La Sapienza, Dept Radiol, Rome, Italy; Univ Aquila, Dept Internal Med & Publ Hlth, I-67100 Laquila, Italy Tombolini, V (reprint author), Osped S Salvatore, UO Radioterapia, Dept Expt Med, Via Vetoio, I-67100 Laquila, Italy. tmbolini52@ciaoweb.it 32 3 3 INT INST ANTICANCER RESEARCH ATHENS EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE 0250-7005 ANTICANCER RES Anticancer Res. JUL-AUG 2005 25 4 3089 3094 6 Oncology Oncology 949PA WOS:000230799400072 J Fatone, L; Recchioni, MC; Scoccia, A; Zirilli, F Fatone, L; Recchioni, MC; Scoccia, A; Zirilli, F The behavior of smart obstacles in electromagnetic scattering: mathematical models as optimal control problems APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL English Article FURTIVITY; ABSORBER We consider a bounded obstacle characterized by a boundary electromagnetic impedance contained in the three dimensional real Euclidean space filled with a homogeneous isotropic medium. When an incoming electromagnetic field illuminates the obstacle a scattered field is generated. A smart obstacle is an obstacle that in the scattering process, circulating a surface electric current density on its boundary, tries to achieve a given goal. We consider four possible goals: making the obstacle undetectable (i.e.: furtivity problem), making the obstacle to appear with a shape and impedance different from its actual ones (i.e.: masking problem), making the obstacle to appear in a location different from its actual one eventually with a shape and impedance different from its actual ones (i.e.: ghost obstacle problem) and finally one of the previous goals limited to a given subset of the frequency space (i.e.: definite band problems). We consider the problem of determining the optimal electric current density to achieve the given goal. The relevance in many application fields (i.e. stealth technology, electromagnetic noise control, etc.) of these problems is well known. The previous problems are modelled as optimal control problems for the Maxwell equations. Some numerical results on test problems obtained solving the optimal control problems proposed are shown. Univ Modena & Reggio Emilia, Dipartimento Matemat Pura & Applicata, Modena, Italy; Univ Politecn Marche, Dipartimento Sci Sociali D Serrani, Ancona, Italy; Univ Roma La Sapienza, Dipartimento Matemat G Castelnuovo, I-00185 Rome, Italy Fatone, L (reprint author), Univ Modena & Reggio Emilia, Dipartimento Matemat Pura & Applicata, Modena, Italy. 11 1 1 APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY UNIVERSITY UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA 1054-4887 APPL COMPUT ELECTROM Appl. Comput. Electromagn. Soc. J. JUL 2005 20 2 119 127 9 Engineering, Electrical & Electronic; Telecommunications Engineering; Telecommunications 953QU WOS:000231095000003 J Asquini, R; Fratalocchi, A; d'Alessandro, A; Assanto, G Asquini, R; Fratalocchi, A; d'Alessandro, A; Assanto, G Electro-optic routing in a nematic liquid-crystal waveguide APPLIED OPTICS English Article SILICON-ON-INSULATOR; 2-MODE INTERFERENCE; DIRECTIONAL COUPLER; SWITCH; MODULATOR; DEVICES; LIGHT We propose a versatile guided-wave geometry encompassing electro-optic control for signal routing. A zero-gap directional coupler in liquid crystal can switch between two output states in the guide plane, permitting signal rerouting with modulation voltages as small as 70 mV. In the absence of an applied bias, no guiding-hence no modal output-is provided by the structure. (c) 2005 Optical Society of America. Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy; Univ Roma La Sapienza, INFM, I-00184 Rome, Italy; Univ Roma Tor Vergata, Dept Elect Engn, Nonlinear Opt & OptoElect Lab, I-00146 Rome, Italy; Univ Roma Tor Vergata, Ist Nazl Fis Mat, I-00146 Rome, Italy Asquini, R (reprint author), Univ Roma La Sapienza, Dept Elect Engn, Via Eudossiana 18, I-00184 Rome, Italy. rita.asquini@uniroma1.it d'Alessandro, Antonio/B-4223-2010; Asquini, Rita/G-8796-2011 33 10 10 OPTICAL SOC AMER WASHINGTON 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA 1559-128X APPL OPTICS Appl. Optics JUL 1 2005 44 19 4136 4143 10.1364/AO.44.004136 8 Optics Optics 940OM WOS:000230153800033 J Larciprete, MC; Savalli, N; Tenev, T; Scalora, M; Leahu, G; Sibilia, C; Baglio, S; Panajotov, K; Bertolotti, M Larciprete, MC; Savalli, N; Tenev, T; Scalora, M; Leahu, G; Sibilia, C; Baglio, S; Panajotov, K; Bertolotti, M Optical switching applications of ZnSe/MgF2 photonic band gap structures based on thermal nonlinearities APPLIED PHYSICS B-LASERS AND OPTICS English Article We investigate a thermo-optical device based on a ZnSe/MgF2 multilayer and demonstrate the modulation of its optical reflectance around the band edge. An electrically induced temperature increase is responsible for the change of the refractive indices of the layers. As a result, the reflection spectrum shifts and the reflected signal decreases. The structure was grown using a thermal evaporation technique, and was designed in such a way that a band edge appears at 632.8 nm, i.e. accessible to a low-power He-Ne laser. The reflection characteristics were investigated as a function of the applied voltage and we found that the photonic band edge shifts by a maximum of 7 nm for an applied voltage of 90 V. Furthermore, different sets of measurements have shown that the spectral shift depends on the voltage squared, thus allowing experimental data analysis in terms of the thermally driven optical nonlinearity. Univ Roma La Sapienza, INFM, Dipartimento Energet, I-00161 Rome, Italy; Univ Catania, Dipartimento Elettr & Sistemist, I-95124 Catania, Italy; Inst Solid State Phys, BU-1784 Sofia, Bulgaria; USA, Aviat & Missile Command, Weap Sci Directorate, AMSAM,RD,WS,ST Redstone Arsenal, Huntsville, AL 35898 USA Larciprete, MC (reprint author), Univ Roma La Sapienza, INFM, Dipartimento Energet, Via A Scarpa 16, I-00161 Rome, Italy. mariacristina.larciprete@uniroma1.it Baglio, Salvatore/I-3174-2012 9 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 245 249 10.1007/s00340-005-1837-y 5 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000018 J Apetrei, AM; Moison, JM; Levenson, JA; Foroni, M; Poli, F; Cucinotta, A; Selleri, S; Legre, M; Wegmuller, M; Gisin, N; Dukel'skii, KV; Khokhlov, AV; Shevandin, VS; Kondrat'ev, YN; Sibilia, C; Serebryannikov, EE; Zheltikov, AM Apetrei, AM; Moison, JM; Levenson, JA; Foroni, M; Poli, F; Cucinotta, A; Selleri, S; Legre, M; Wegmuller, M; Gisin, N; Dukel'skii, KV; Khokhlov, AV; Shevandin, VS; Kondrat'ev, YN; Sibilia, C; Serebryannikov, EE; Zheltikov, AM Electromagnetic field confined and tailored with a few air holes in a photonic-crystal fiber APPLIED PHYSICS B-LASERS AND OPTICS English Article MICROSTRUCTURED OPTICAL-FIBER; FEMTOSECOND LASER-PULSES; WAVE-GUIDE ENHANCEMENT; SELF-FREQUENCY SHIFT; SUPERCONTINUUM GENERATION; HOLLOW-CORE; FLATTENED DISPERSION; RAMAN-SCATTERING; CONVERSION; LIGHT Conventional and scanning near-field optical microscopy techniques are cross referenced to femtosecond nonlinear-optical measurements and finite-element numerical simulations to visualize and analyze a strong confinement of electromagnetic radiation in guided modes of a photonic-crystal fiber with only a few air holes surrounding the fiber core. A nonlinear coefficient of about 120 W-1 km(-1) is achieved at the wavelength of 670 nm for a fused-silica fiber with a full hexagonal cycle of closely packed air holes around the fiber core. The removal of a single element from this array of air holes is shown to frustrate field confinement in guided modes, leading to mode leakage. Moscow MV Lomonosov State Univ, Ctr Int Laser, Dept Phys, Moscow 119992, Russia; LPN, CNRS, Route Nozay, F-91460 Marcoussis, France; Univ Parma, Dept Informat Engn, I-43100 Parma, Italy; Univ Geneva, Sect Phys GAP Opt, CH-1211 Geneva, Switzerland; SI Vavilov State Opt Inst, St Petersburg 199034, Russia; Univ Roma La Sapienza, Dipartimento Energet, I-00161 Rome, Italy Zheltikov, AM (reprint author), Moscow MV Lomonosov State Univ, Ctr Int Laser, Dept Phys, Vorobevy Gory, Moscow 119992, Russia. zheltikov@phy.msu.ru APETREI, ALIN MARIAN/B-5811-2013; Selleri, Stefano/K-1343-2013 APETREI, ALIN MARIAN/0000-0002-2036-7139; 53 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 409 414 10.1007/s00340-005-1855-9 6 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000043 J Di Falco, A; Conti, C; Assanto, G Di Falco, A; Conti, C; Assanto, G Transient-mode excitation, terahertz generation and wavelength shifting in a photonic band gap APPLIED PHYSICS B-LASERS AND OPTICS English Article PARAMETRIC OSCILLATIONS; ISOTROPIC MEDIA; CRYSTAL SLABS; WAVE-GUIDES; MICROCAVITIES; PROPAGATION Dynamic responses of photonic crystal microcavities in nonlinear media are analyzed via both a finite-difference code and coupled-mode theory in the time domain. Optical frequency generation in both second- and third-order nonlinear materials is demonstrated based on the transient evolution of cavity modes. Terahertz waves can be generated in quadratically nonlinear crystals by optical rectification, whereas state generation inside the band gap can be linked to a Rabi-like splitting in cubic media. An all-optical ultra-fast wavelength shifter is proposed. Univ Roma Tre, Dept Elect Engn, INFM, Nonlinear & Optoelect Lab, I-00146 Rome, Italy; Ctr E Fermi, I-00184 Rome, Italy; Univ Palermo, Dept Elect Engn, I-90128 Palermo, Italy; Univ Roma La Sapienza, INFM, CRS SOFT, I-00185 Rome, Italy Di Falco, A (reprint author), Univ Roma Tre, Dept Elect Engn, INFM, Nonlinear & Optoelect Lab, Via Vasca Navale 84, I-00146 Rome, Italy. difalco@ele.uniroma3.it Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 30 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0946-2171 APPL PHYS B-LASERS O Appl. Phys. B-Lasers Opt. JUL 2005 81 2-3 415 420 10.1007/s00340-005-1885-3 6 Optics; Physics, Applied Optics; Physics 947DQ WOS:000230624000044 J Gallo, A; Manciocco, V; Simonelli, M; Pagliuca, G; D'Arcangelo, E; de Vincentiis, M Gallo, A; Manciocco, V; Simonelli, M; Pagliuca, G; D'Arcangelo, E; de Vincentiis, M Supracricoid partial laryngectomy in the treatment of laryngeal cancer - Univariate and multivariate analysis of prognostic factors ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY English Article; Proceedings Paper 6th International Conference on Head and Neck Cancer AUG 09, 2004 Washington, DC Amer Head & Neck Soc SUPRAGLOTTIC CARCINOMA; GLOTTIC CARCINOMA; CRICOHYOIDOPEXY; CRICOHYOIDOEPIGLOTTOPEXY; MANAGEMENT; RESECTION Objectives: To evaluate the oncological results of supracricoid partial laryngectomy as a treatment for selected glottic and supraglottic cancer in a large series of patients who had undergone uniform treatment over a 16-year period and to determine the different prognostic factors that may influence local control and survival. Design: Retrospective clinical study. Setting: Academic tertiary referral medical center. Patients: The study population comprised 253 consecutive patients (234 men and 19 women) with glottic and supraglottic squamous cell carcinoma. The mean age was 58 years for men and 59.2 years for women. Intervention: Supracricoid partial laryngectomy: 180 patients had undergone cricohyoidopexy and 73 had undergone cricohyoidoepiglottopexy. Main Outcome Measures: Local control and overall survival. Potential prognostic factors for local control and survival were evaluated with univariate and multivariate models. Results: The 3-, 5-, 10-, and 16-year overall survival rates in this group of 253 patients were 85.8%, 79.1%, 57.6%, and 57.6%, respectively. With regard to local control, univariate and multivariate analyses showed that a positive resection margin was the only important predictor of local control and that a dysplastic lesion at the margin of resection is just as aggressive as the presence of invasive carcinoma. When considering the prognostic factors influencing survival, univariate analysis showed that the tumor category, lymph node category, tumor stage, and recurrence all had a significant influence on the survival rate. Multivariate analysis showed that the most important predictor of survival was recurrence. Conclusions: Supracricoid partial laryngectomy is a valid choice in the treatment of selected glottic and supraglottic cancer while maintaining laryngeal functions and achieving a high rate of local control. T category, N category, tumor stage, positive resection margins, and recurrence are the most important predictors of oncological outcome. Univ Roma La Sapienza, Dept Otorhinolaryngol, Rome, Italy; Univ Roma La Sapienza, Dept Stat, Rome, Italy; St Lucia Hosp, Speech & Swallowing Rehabil Serv, Rome, Italy Gallo, A (reprint author), Via Adolfo Venturi 19, I-00162 Rome, Italy. andrea.gallo@uniroma1.it 25 28 30 AMER MEDICAL ASSOC CHICAGO 515 N STATE ST, CHICAGO, IL 60610 USA 0886-4470 ARCH OTOLARYNGOL Arch. Otolaryngol. Head Neck Surg. JUL 2005 131 7 620 625 10.1001/archotol.131.7.620 6 Otorhinolaryngology; Surgery Otorhinolaryngology; Surgery 944EO WOS:000230409300015 J Raiteri, CM; Villata, M; Ibrahimov, MA; Larionov, VM; Kadler, M; Aller, HD; Aller, MF; Kovalev, YY; Lanteri, L; Nilsson, K; Papadakis, IE; Pursimo, T; Romero, GE; Terasranta, H; Tornikoski, M; Arkharov, AA; Barnaby, D; Berdyugin, A; Bottcher, M; Byckling, K; Carini, MT; Carosati, D; Cellone, SA; Ciprini, S; Combi, JA; Crapanzano, S; Crowe, R; Di Paola, A; Dolci, M; Fuhrmann, L; Gu, M; Hagen-Thorn, VA; Hakala, P; Impellizzeri, V; Jorstad, S; Kerp, J; Kimeridze, GN; Kovalev, YA; Kraus, A; Krichbaum, TP; Kurtanidze, OM; Lahteenmaki, A; Lindfors, E; Mingaliev, MG; Nesci, R; Nikolashvili, MG; Ohlert, J; Orio, M; Ostorero, L; Pasanen, M; Pati, A; Poteet, C; Ros, E; Ros, JA; Shastri, P; Sigua, LA; Sillanpaa, A; Smith, N; Takalo, LO; Tosti, G; Vasileva, A; Wagner, SJ; Walters, R; Webb, JR; Wills, W; Witzel, A; Xilouris, E Raiteri, CM; Villata, M; Ibrahimov, MA; Larionov, VM; Kadler, M; Aller, HD; Aller, MF; Kovalev, YY; Lanteri, L; Nilsson, K; Papadakis, IE; Pursimo, T; Romero, GE; Terasranta, H; Tornikoski, M; Arkharov, AA; Barnaby, D; Berdyugin, A; Bottcher, M; Byckling, K; Carini, MT; Carosati, D; Cellone, SA; Ciprini, S; Combi, JA; Crapanzano, S; Crowe, R; Di Paola, A; Dolci, M; Fuhrmann, L; Gu, M; Hagen-Thorn, VA; Hakala, P; Impellizzeri, V; Jorstad, S; Kerp, J; Kimeridze, GN; Kovalev, YA; Kraus, A; Krichbaum, TP; Kurtanidze, OM; Lahteenmaki, A; Lindfors, E; Mingaliev, MG; Nesci, R; Nikolashvili, MG; Ohlert, J; Orio, M; Ostorero, L; Pasanen, M; Pati, A; Poteet, C; Ros, E; Ros, JA; Shastri, P; Sigua, LA; Sillanpaa, A; Smith, N; Takalo, LO; Tosti, G; Vasileva, A; Wagner, SJ; Walters, R; Webb, JR; Wills, W; Witzel, A; Xilouris, E The WEBT campaign to observe AO 0235+16 in the 2003-2004 observing season - Results from radio-to-optical monitoring and XMM-Newton observations ASTRONOMY & ASTROPHYSICS English Article galaxies : active; BL Lacertae objects : general; BL Lacertae objects : individual : AO 0235+16 BL-LACERTAE OBJECTS; ACTIVE GALACTIC NUCLEI; X-RAY-SPECTRA; INTRADAY VARIABILITY; AO 0235+164; INTERSTELLAR SCINTILLATION; LIGHT CURVES; RAPID VARIABILITY; EGRET BLAZARS; LOUD BLAZARS A multiwavelength campaign to observe the BL Lac object AO 0235+ 16 ( z = 0.94) was set up by the Whole Earth Blazar Telescope (WEBT) collaboration during the observing seasons 2003-2004 and 2004-2005, involving radio, near-IR and optical photometric monitoring, VLBA monitoring, optical spectral monitoring, and three pointings by the XMM-Newton satellite. Here we report on the results of the first season, which involved the participation of 24 optical and near-IR telescopes and 4 radio telescopes, as well as the first XMM-Newton pointing, which occurred on January 18-19, 2004. Unpublished data from previous epochs were also collected ( from 5 optical-NIR and 3 radio telescopes), in order to fill the gap between the end of the period presented in Raiteri et al. ( 2001) and the start of the WEBT campaign. The contribution of the southern AGN, 2 arcsec distant from the source, is taken into account. It is found to especially affect the blue part of the optical spectrum when the source is faint. In the optical and near-IR the source has been very active in the last 3 years, although it has been rather faint most of the time, with noticeable variations of more than a magnitude over a few days. In contrast, in the radio bands it appears to have been "quiescent" since early 2000. The major radio ( and optical) outburst predicted to peak around February-March 2004 ( with a six month uncertainty) has not occurred yet. When comparing our results with the historical light curves, two different behaviours seem to characterize the optical outbursts: only the major events present a radio counterpart. The X-ray spectra obtained by the three EPIC detectors are well fitted by a power law with extra-absorption at z = 0.524; the energy index in the 0.2-10 keV range is well constrained: alpha = 0.645 +/- 0.028 and the 1 keV flux density is 0.311 +/- 0.008 mu Jy. The analysis of the X-ray light curves reveals that no significant variations occurred during the pointing. In contrast, simultaneous dense radio monitoring with the 100 m telescope at Effelsberg shows a similar to 2 - 3% flux decrease in 6 - 7 h, which, if intrinsic, would imply a brightness temperature well above the Compton limit and hence a lower limit to the Doppler factor delta greater than or similar to 46. We construct the broad-band spectral energy distribution of January 18 - 19, 2004 with simultaneous radio data from Effelsberg, optical data from the Nordic Optical Telescope ( NOT), optical-UV data from the Optical Monitor onboard XMM-Newton, and X-ray data by the EPIC instruments. Particular care is taken to correct data for extinction due to both the Milky Way and the z = 0.524 absorber. The resulting SED suggests the existence of a bump in the UV spectral region. Osserv Astron Torino, INAF, Turin, Italy; St Petersburg State Univ, Astron Inst, St Petersburg, Russia; Univ Michigan, Dept Astron, Ann Arbor, MI 48109 USA; Natl Radio Astron Observ, Green Bank, WV USA; PN Lebedev Phys Inst, Ctr Astro Space, Moscow, Russia; Tuorla Astron Observ, Piikkio, Finland; Univ Crete, Dept Phys, Rethimnon, Greece; Nord Opt Telescope, Santa Cruz De La Palma, Spain; Helsinki Univ Technol, Metsahovi Radio Observ, FIN-02150 Espoo, Finland; Pulkovo Observ, St Petersburg, Russia; Western Kentucky Univ, Dept Phys & Astron, Bowling Green, KY 42101 USA; Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA; Univ Helsinki, Observ, FIN-00014 Helsinki, Finland; Univ Jaen, Dept Fis, Escuela Politecn Super, Jaen, Spain; Univ Hawaii, Dept Phys & Astron, Honolulu, HI 96822 USA; Osserv Astron Roma, INAF, Rome, Italy; Univ Perugia, Osservatorio Astron, I-06100 Perugia, Italy; Boston Univ, Inst Astrophys Res, Boston, MA 02215 USA; Abastumani Observ, Abastumani, Rep of Georgia; Special Astrophys Observ, Karachaevo Cherkessia, Russia; Univ Roma La Sapienza, Dipartimento Fis, Rome, Italy; Michael Adrian Observ, Trebur, Germany; Landessternwarte Konigstuhl, D-6900 Heidelberg, Germany; Indian Inst Astrophys, Bangalore 560034, Karnataka, India; Cork Inst Technol, Dept Appl Phys & Instrumentat, Cork, Ireland; Florida Int Univ, SARA Observ, Miami, FL 33199 USA; Natl Observ Athens, Inst Astron & Astrophys, Athens, Greece Raiteri, CM (reprint author), Osserv Astron Torino, INAF, Turin, Italy. villata@to.astro.it Papadakis, Iossif/C-3235-2011; Tosti, Gino/E-9976-2013; Larionov, Valeri/H-1349-2013; Xilouris, Emmanuel/K-9459-2013; Kovalev, Yuri/J-5671-2013 73 44 46 EDP SCIENCES LES ULIS CEDEX A 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE 0004-6361 ASTRON ASTROPHYS Astron. Astrophys. JUL 2005 438 1 39 53 10.1051/0004-6361:20042567 15 Astronomy & Astrophysics Astronomy & Astrophysics 943XC WOS:000230387800008 J De Rosa, A; Piro, L; Tramacere, A; Massaro, E; Walter, R; Bassani, L; Malizia, A; Bird, AJ; Dean, AJ De Rosa, A; Piro, L; Tramacere, A; Massaro, E; Walter, R; Bassani, L; Malizia, A; Bird, AJ; Dean, AJ The broad-band X-ray spectrum of the blazar PKSB1830-211 by Chandra and INTEGRAL ASTRONOMY & ASTROPHYSICS English Article radiation mechanisms : non-thermal; galaxies : active; X-rays : galaxies : individual : PKSB1830-211 GRAVITATIONAL LENS; RADIO-SOURCE; PKS-1830-211; EMISSION; REDSHIFT; QUASARS; CATALOG; PKS1830-211; ABSORPTION; Z=4.4 In this paper we present a broad-band study of the X-ray emission of the blazar PKS 1830-211 based on Chandra and INTEGRAL observations. Notwithstanding the high redshift ( z = 2.507), it is a bright X-ray source (F(2 - 10 keV) similar or equal to 10(-11) erg cm(-2) s(-1)), due to gravitational lensing by an intervening galaxy at z = 0.89. Previous X-ray observations attribute the observed absorption at E < 2 keV to the lensing galaxy. Our analysis, although not in contrast with this hypothesis, suggests also the possibility of an intrinsic ( ionized) absorption, taking place at the front side of the jet. This scenario is also supported by some evidence, in the same data, of a feature observed at 2.15 keV which can be interpreted as a blueshifted iron line (v/ c similar or equal to 0.18). The SED of PKS 1830-211 can be well modelled by combining a Synchrotron Self-Compton component and an external source of photons to be scattered up to gamma-ray energies by relativistic electrons moving outward in the jet. The main source of low energy photons is a dust torus at the temperature of 103 K as expected in MeV blazars. INAF, IASF, Sez Roma, I-00113 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Observ Geneva, INTEGRAL Sci Data Ctr, CH-1291 Versoix, Switzerland; INAF, IASF Sez Bologna, I-40129 Bologna, Italy; Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, Hants, England De Rosa, A (reprint author), INAF, IASF, Sez Roma, Via Fosso Cavaliere 100, I-00113 Rome, Italy. derosa@rm.iasf.cnr.it 33 23 23 EDP SCIENCES LES ULIS CEDEX A 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE 0004-6361 ASTRON ASTROPHYS Astron. Astrophys. JUL 2005 438 1 121 126 10.1051/000-6361:20052710 6 Astronomy & Astrophysics Astronomy & Astrophysics 943XC WOS:000230387800013 J Braccini, S; Barsotti, L; Bradaschia, C; Cella, G; Di Virgilio, A; Ferrante, I; Fidecaro, F; Fiori, I; Frasconi, F; Gennai, A; Giazotto, A; Paoletti, F; Passaquieti, R; Passuello, D; Poggiani, R; Campagna, E; Guidi, G; Losurdo, G; Martelli, F; Mazzoni, M; Perniola, B; Piergiovanni, F; Stanga, R; Vetrano, F; Vicere, A; Brocco, L; Frasca, S; Majorana, E; Pai, A; Palomba, C; Puppo, P; Rapagnani, P; Ricci, F; Ballardin, G; Barille, R; Cavalieri, R; Cuoco, E; Dattilo, V; Enard, D; Flaminio, R; Freise, A; Hebri, S; Holloway, L; La Penna, P; Loupias, M; Marque, J; Moins, C; Pasqualetti, A; Ruggi, P; Taddei, R; Zhang, Z; Acernese, F; Avino, S; Barone, F; Calloni, E; De Rosa, R; Di Fiore, L; Eleuteri, A; Giordano, L; Milano, L; Pardi, S; Qipiani, K; Ricciardi, I; Russo, G; Solimeno, S; Babusci, D; Giordano, G; Amico, P; Bosi, L; Gammaitoni, L; Marchesoni, F; Punturo, M; Travasso, F; Vocca, H; Boccara, C; Moreau, J; Loriette, V; Reita, V; Mackowski, JM; Morgado, N; Pinard, L; Remillieux, A; Barsuglia, M; Bizouard, MA; Brisson, V; Cavalier, F; Clapson, AC; Davier, M; Hello, P; Krecklbergh, S; Beauville, F; Buskulic, D; Gouaty, R; Grosjean, D; Marion, F; Masserot, A; Mours, B; Tournefier, E; Tombolato, D; Verkindt, D; Yvert, M; Aoudia, S; Bondu, F; Brillet, A; Chassande-Mottin, E; Cleva, F; Coulon, JP; Dujardin, B; Fournier, JD; Heitmann, H; Man, CN; Spallicci, A; Vinet, JY Braccini, S; Barsotti, L; Bradaschia, C; Cella, G; Di Virgilio, A; Ferrante, I; Fidecaro, F; Fiori, I; Frasconi, F; Gennai, A; Giazotto, A; Paoletti, F; Passaquieti, R; Passuello, D; Poggiani, R; Campagna, E; Guidi, G; Losurdo, G; Martelli, F; Mazzoni, M; Perniola, B; Piergiovanni, F; Stanga, R; Vetrano, F; Vicere, A; Brocco, L; Frasca, S; Majorana, E; Pai, A; Palomba, C; Puppo, P; Rapagnani, P; Ricci, F; Ballardin, G; Barille, R; Cavalieri, R; Cuoco, E; Dattilo, V; Enard, D; Flaminio, R; Freise, A; Hebri, S; Holloway, L; La Penna, P; Loupias, M; Marque, J; Moins, C; Pasqualetti, A; Ruggi, P; Taddei, R; Zhang, Z; Acernese, F; Avino, S; Barone, F; Calloni, E; De Rosa, R; Di Fiore, L; Eleuteri, A; Giordano, L; Milano, L; Pardi, S; Qipiani, K; Ricciardi, I; Russo, G; Solimeno, S; Babusci, D; Giordano, G; Amico, P; Bosi, L; Gammaitoni, L; Marchesoni, F; Punturo, M; Travasso, F; Vocca, H; Boccara, C; Moreau, J; Loriette, V; Reita, V; Mackowski, JM; Morgado, N; Pinard, L; Remillieux, A; Barsuglia, M; Bizouard, MA; Brisson, V; Cavalier, F; Clapson, AC; Davier, M; Hello, P; Krecklbergh, S; Beauville, F; Buskulic, D; Gouaty, R; Grosjean, D; Marion, F; Masserot, A; Mours, B; Tournefier, E; Tombolato, D; Verkindt, D; Yvert, M; Aoudia, S; Bondu, F; Brillet, A; Chassande-Mottin, E; Cleva, F; Coulon, JP; Dujardin, B; Fournier, JD; Heitmann, H; Man, CN; Spallicci, A; Vinet, JY Measurement of the seismic attenuation performance of the VIRGO Superattenuator ASTROPARTICLE PHYSICS English Article SUSPENSION SYSTEM; INTERFEROMETER; NOISE; SENSITIVITY; SENSOR; BAND The gravitational wave detector VIRGO aims at extending the detection band down to a few Hertz by isolating the mirrors of the interferometer from seismic noise. This result is achieved by hanging each mirror through an elastic suspension (Superattenuator), designed to filter mechanical vibrations in all the degrees of freedom. An experimental upper limit of the mirror residual seismic noise at a few Hertz is provided in this paper. This is lower than the thermal noise floor, expected to limit the antenna sensitivity in the low frequency range. (c) 2005 Elsevier B.V. All rights reserved. Univ Pisa, Sez Pisa Andlor, Ist Nazl Fis Nucl, I-56127 Pisa, Italy; Sez Firenze Urbino, Ist Nazl Fis Nucl, I-50019 Florence, Italy; Univ Florence, I-50125 Florence, Italy; Univ Urbino, I-61029 Urbino, Italy Braccini, S (reprint author), Univ Pisa, Sez Pisa Andlor, Ist Nazl Fis Nucl, Via F Buonarroti 2, I-56127 Pisa, Italy. stefano.braccini@pi.infn.it Gammaitoni, Luca/B-5375-2009; ricciardi, iolanda/D-5527-2009; Acernese, Fausto/E-4989-2010; Freise, Andreas/F-8892-2011; Marchesoni, Fabio/A-1920-2008; Bondu, Francois/A-2071-2012; Cella, Giancarlo/A-9946-2012; Vocca, Helios/F-1444-2010; Punturo, Michele/I-3995-2012; Ferrante, Isidoro/F-1017-2012; Cuoco, Elena/I-8789-2012; Vicere, Andrea/J-1742-2012; Puppo, Paola/J-4250-2012; Rapagnani, Piero/J-4783-2012 Marchesoni, Fabio/0000-0001-6422-2516; Cella, Giancarlo/0000-0002-0752-0338; Punturo, Michele/0000-0001-8722-4485; Puppo, Paola/0000-0003-4677-5015; 23 37 37 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0927-6505 ASTROPART PHYS Astropart Phys. JUL 2005 23 6 557 565 10.1016/j.astropartphys.2005.04.002 9 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 954VZ WOS:000231184600003 J Fontana, M; Amendola, D; Orsini, E; Boffi, A; Pecci, L Fontana, M; Amendola, D; Orsini, E; Boffi, A; Pecci, L Oxidation of hypotaurine and cysteine sulphinic acid by peroxynitrite BIOCHEMICAL JOURNAL English Article cysteine sulphinic acid; hypotaurine; peroxynitrite; reactive sulphur species; sulphonyl radical; taurine HYDROXYL RADICAL FORMATION; NITRIC-OXIDE; CARBON-DIOXIDE; LIPID-PEROXIDATION; ONE-ELECTRON; BIOLOGICAL-ACTIVITY; AQUEOUS-SOLUTION; SINGLET OXYGEN; THIYL RADICALS; AMINO-ACIDS Peroxynitrite mediates the oxidation of the sulphinic group of both HTAU (hypotaurine) and CSA (cysteine sulphinic acid), producing the respective sulphonates, TAU (taurine) and CA (cysteic acid). The reaction is associated with extensive oxygen uptake, suggesting that HTAU and CSA are oxidized by the one-electron transfer mechanism to sulphonyl radicals, which may initiate an oxygen-dependent radical chain reaction with the sulphonates as final products. Besides the one-electron mechanism, HTAU and CSA can be oxidized by the two-electron pathway, leading directly to sulphonate formation without oxygen consumption. The apparent second-order rate constants for the direct reaction of peroxynitrite with HTAU and CSA at pH 7.4 and 25 degrees C are 77.4 +/- 5 and 76.4 +/- 9 M-1.s(-1) respectively. For both sulphinates, the apparent second-order rate constants increase sharply with decrease in pH, and the sigmoidal curves obtained are consistent with peroxynitrous acid as the species responsible for sulphinate oxidation. The kinetic data, together with changes in oxygen uptake, sulphinate depletion, sulphonate production, and product distribution of nitrite and nitrate, suggest that oxidation of sulphinates by peroxynitrite may take place by the two reaction pathways whose relative importance depends on reagent concentrations and pH value. In the presence of bicarbonate, the direct reaction of sulphinates with peroxynitrite is inhibited and the oxidative reaction probably involves only the radicals (NO2)-N-center dot and CO3center dot-, generated by decomposition of the peroxynitrite-CO2 adduct. Univ Roma La Sapienza, CNR, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy; Univ Roma La Sapienza, Inst Mol Biol & Pathol, CNR, I-00185 Rome, Italy Fontana, M (reprint author), Univ Roma La Sapienza, CNR, Dept Biochem Sci A Rossi Fanelli, Piazzale Aldo Moro 5, I-00185 Rome, Italy. mario.fontana@uniroma1.it 68 7 7 PORTLAND PRESS LTD LONDON THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND 0264-6021 BIOCHEM J Biochem. J. JUL 1 2005 389 1 233 240 10.1042/BJ20041696 8 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 944XU WOS:000230465200027 J Bossa, C; Amadei, A; Daidone, I; Anselmi, M; Vallone, B; Brunori, M; Di Nola, A Bossa, C; Amadei, A; Daidone, I; Anselmi, M; Vallone, B; Brunori, M; Di Nola, A Molecular dynamics simulation of sperm whale myoglobin: Effects of mutations and trapped CO on the structure and dynamics of cavities BIOPHYSICAL JOURNAL English Article X-RAY CRYSTALLOGRAPHY; CARBON-MONOXIDE; MUTANT MYOGLOBIN; LIGAND MIGRATION; PROTEIN; MOTIONS; CONSISTENCY; NANOSECOND; DIFFUSION; PATHWAYS The results of extended (80-ns) molecular dynamics simulations of wild-type and YQR triple mutant of sperm whale deoxy myoglobin in water are reported and compared with the results of the simulation of the intermediate(s) obtained by photodissociation of CO in the wild-type protein. The opening/closure of pathways between preexistent cavities is different in the three systems. For the photodissociated state, we previously reported a clear-cut correlation between the opening probability and the presence of the photolyzed CO in the proximity of the passage; here we show that in wild-type deoxy myoglobin, opening is almost random. In wild-type deoxy myoglobin, the passage between the distal pocket and the solvent is strictly correlated to the presence/absence of a water molecule that simultaneously interacts with the distal histidine side chain and the heme iron; conversely, in the photodissociated myoglobin, the connection with the bulk solvent is always open when CO is in the vicinity of the A pyrrole ring. In YQR deoxy myoglobin, the mutated Gln(E7)64 is stably H-bonded with the mutated Tyr(B10)29. The essential dynamics analysis unveils a different behavior for the three systems. The motion amplitude is progressively restricted in going from wild-type to YQR deoxy myoglobin and to wild-type myoglobin photoproduct. In all cases, the principal motions involve mainly the same regions, but their directions are different. Analysis of the dynamics of the preexisting cavities indicates large fluctuations and frequent connections with the solvent, in agreement with the earlier hypothesis that some of the ligand may escape from the protein through these pathways. Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, Rome, Italy; Univ Roma La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy Bossa, C (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Piazzale Aldo Moro 5, I-00185 Rome, Italy. cebossa@caspur.it Vallone, Beatrice/F-4174-2012 43 60 62 BIOPHYSICAL SOCIETY BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA 0006-3495 BIOPHYS J Biophys. J. JUL 2005 89 1 465 474 10.1529/biophysj.104.055020 10 Biophysics Biophysics 939ZX WOS:000230114500049 J Amadori, S; Suciu, S; Jehn, U; Stasi, R; Thomas, X; Marie, JP; Muus, P; Lefrere, F; Berneman, Z; Fillet, G; Denzlinger, C; Willemze, R; Leoni, P; Leone, G; Casini, M; Ricciuti, F; Vignetti, M; Beeldens, F; Mandelli, F; De Witte, T Amadori, S; Suciu, S; Jehn, U; Stasi, R; Thomas, X; Marie, JP; Muus, P; Lefrere, F; Berneman, Z; Fillet, G; Denzlinger, C; Willemze, R; Leoni, P; Leone, G; Casini, M; Ricciuti, F; Vignetti, M; Beeldens, F; Mandelli, F; De Witte, T EORTC GIMENA Leukemia Grps Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia final results of AML-13, a randomized phase-3 study BLOOD English Article COLONY-STIMULATING FACTOR; ACUTE MYELOGENOUS LEUKEMIA; PLACEBO-CONTROLLED TRIAL; SOUTHWEST-ONCOLOGY-GROUP; ADULT PATIENTS GREATER-THAN-55; COUNCIL AML11 TRIAL; ELDERLY-PATIENTS; DOUBLE-BLIND; CYTOSINE-ARABINOSIDE; COOPERATIVE GROUP The role of glycosylated recombinant human granulocyte colony-stimulating factor (G-CSF) in the induction treatment of older adults with acute myeloid leukemia (AML) is still uncertain. In this trial, a total of 722 patients with newly diagnosed AML, median age 68 years, were randomized into 4 treatment arms: (A) no G-CSIF; (B) G-CSIF during chemotherapy; (C) G-CSIF after chemotherapy until day 28 or recovery of polymorphonuclear leukocytes; and (D) G-CSIF during and after chemotherapy. The complete remission (CR) rate was 48.9% in group A, 52.2% in group B, 48.3% in group C, and 64.4% in group D. Analysis according to the 2 x 2 factorial design indicated that the CR rate was significantly higher in patients who received G-CSF during chemotherapy (58.3% for groups B + D vs 48.6% for groups A + C; P =.009), whereas no significant difference was observed between groups A + B and C + D (50.6% vs 56.4%, P =.12). In terms of overall survival, no significant differences were observed between the various groups. Patients who received G-CSIF after chemotherapy had a shorter time to neutrophil recovery (median, 20 vs 25 days; P <.001) and a shorter hospitalization (mean, 27.2 vs 29.7 days; P <.001). We conclude that although priming with G-CSF can improve the CR rate, the use of G-CSF during and/or after chemotherapy has no effect on the long-term outcome of AML in older patients. Univ Roma Tor Vergata, Dept Hematol, I-00144 Rome, Italy; Eortc Data Ctr, Brussels, Belgium; Univ Munich, Klinikum Grosshadern, Dept Hematol, D-8000 Munich, Germany; Regina Apostolorum Hosp, Hematol Unit, Albano Laziale, Italy; Hop Edouard Herriot, Dept Hematol, Lyon, France; Hop Hotel Dieu, Dept Hematol, F-75181 Paris, France; Univ Nijmegen, Radboud Med Ctr, Dept Hematol, Nijmegen, Netherlands; Hop Necker Enfants Malad, Dept Hematol, Paris, France; Univ Hosp, Dept Hematol, Edegem, Belgium; Sart Tilman Hosp, Dept Hematol, Liege, Belgium; Univ Tubingen Hosp, Dept Hematol, Tubingen, Germany; Univ Leiden Hosp, Dept Hematol, NL-2300 RC Leiden, Netherlands; Univ Hosp, Dept Hematol, Ancona, Italy; Catholic Univ Rome, Dept Hematol, Rome, Italy; Gen Hosp, Dept Hematol, Bolzano, Italy; San Carlo Hosp, Dept Hematol, Potenza, Italy; GIMEMA, Rome, Italy; Univ Roma La Sapienza, Dept Hematol, Rome, Italy Amadori, S (reprint author), Univ Roma Tor Vergata, St Eugeino Hosp, Dept Hematol, Ple Umanesimo 10, I-00144 Rome, Italy. mc7673@mclink.it 42 85 89 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood JUL 1 2005 106 1 27 34 10.1182/blood-2004-09-3728 8 Hematology Hematology 940PN WOS:000230156500012 J Capria, S; Latagliata, R; Avvisati, G; Breccia, M; Cimino, G; Diverio, D; Petti, MC; Meloni, G Capria, S; Latagliata, R; Avvisati, G; Breccia, M; Cimino, G; Diverio, D; Petti, MC; Meloni, G BAVC regimen and autologous bone marrow transplantation for APL patients in second molecular remission: updated results BONE MARROW TRANSPLANTATION English Letter ACUTE PROMYELOCYTIC LEUKEMIA Univ Roma La Sapienza, Div Hematol, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome, Italy; Univ Campus Biomed, Rome, Italy; Ist Regina Elena, I-00161 Rome, Italy Capria, S (reprint author), Univ Roma La Sapienza, Div Hematol, Dipartimento Biotecnol Cellulari & Ematol, Via Benevento 6, I-00161 Rome, Italy. 5 6 6 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0268-3369 BONE MARROW TRANSPL Bone Marrow Transplant. JUL 2005 36 1 83 84 10.1038/sj.bmt.1704995 2 Biophysics; Oncology; Hematology; Immunology; Transplantation Biophysics; Oncology; Hematology; Immunology; Transplantation 937ID WOS:000229916900011 J Torelli, GF; Guarini, A; Porzia, A; Chiaretti, S; Tatarelli, C; Diverio, D; Maggio, R; Vitale, A; Ritz, J; Foa, R Torelli, GF; Guarini, A; Porzia, A; Chiaretti, S; Tatarelli, C; Diverio, D; Maggio, R; Vitale, A; Ritz, J; Foa, R FLT3 inhibition in t(4;11)+ adult acute lymphoid leukaemia BRITISH JOURNAL OF HAEMATOLOGY English Article FLT3; acute lymphoid leukaemia; targeted therapy; kinase inhibition; signal transduction ACUTE LYMPHOBLASTIC-LEUKEMIA; TYROSINE KINASE INHIBITOR; MINIMAL-RESIDUAL-DISEASE; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA; GENE-EXPRESSION PROFILE; PHASE-I; MUTATIONS; ASSOCIATION; RECEPTOR The present study was designed to investigate, in t(4;11)+ adult lymphoid leukaemia (ALL) blast cells, the pathogenetic role of the FLT3 protein, its level of mRNA and protein expression, the degree of constitutive phosphorylation, the possible presence of mutations of the sequence, the capacity of signal transduction and the potential therapeutic role of specific inhibitors. We evaluated nine adult ALL patients carrying this translocation. The increased FLT3 mRNA levels, determined by oligonucleotide microarray analysis, was in agreement with the increased protein expression evaluated by Western blot. The protein was constitutively phosphorylated in all cases analysed. Polymerase chain reaction detected no internal tandem duplication or point mutations. The signal transduction apparatus, after stimulation with the specific ligand, was preserved. We then investigated the effect of specific FLT3 inhibition on signal transduction and survival. The PKC412 inhibitor specifically inhibited ligand-induced phosphorylation; the same inhibitor reduced the survival of leukaemic cells when compared with untreated cells. These data indicate that the FLT3 protein might play a role in this subgroup of ALL with a particularly poor prognosis. Specific inhibition of the kinase receptor must be hypothesised as an innovative therapeutic tool for t(4;11)+ ALL patients. Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Div Haematol, I-00161 Rome, Italy; Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA Foa, R (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Div Haematol, Via Benevento 6, I-00161 Rome, Italy. rfoa@bce.uniroma1.it Ritz, Jerome/C-7929-2009 Ritz, Jerome/0000-0001-5526-4669 46 14 14 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0007-1048 BRIT J HAEMATOL Br. J. Haematol. JUL 2005 130 1 43 50 10.1111/j.1365-2141.2005.05556.x 8 Hematology Hematology 940AN WOS:000230116200005 J Battaglia, PA; Ponti, D; Naim, V; Venanzi, S; Psaila, R; Gigliani, F Battaglia, PA; Ponti, D; Naim, V; Venanzi, S; Psaila, R; Gigliani, F The HIV-Tat protein induces chromosome number aberrations by affecting mitosis CELL MOTILITY AND THE CYTOSKELETON English Article HIV-Tat-tubulin interaction; chromosome aberrations; Drosophila HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOPLASMIC DYNEIN; DROSOPHILA EMBRYO; CELLS; TRANSDUCTION; CHECKPOINT; IDENTIFICATION; CYTOSKELETON; CENTROSOMES; CENTROMERES To analyze the effects of the HIV-Tat-tubulin interaction, we microinjected HIV-Tat purified protein into Drosophila syncytial embryos. Following the Tat injection, altered timing of the cortical nuclear cycles was observed; specifically, the period between the nuclear envelope breakdown and anaphase initiation was lengthened as was the period between anaphase initiation and the fort-nation of the next nuclear envelope. These two periods correspond to kinetochore alignment at metaphase and to mitosis exit, respectively. We also demonstrated that these two delays are the consequence of damage specifically induced by Tat on kinetochore alignment and on the timing of sister chromatid segregation at anaphase. Furthermore, we show that the expression of Tat in Drosophila larvae brain cells produces a significant percentage of polyploid and aneuploid cells. The results reported here indicate that Tat impairs the mitotic process and that Tat-tubulin interaction appears to be responsible for the observed defects. The presence of polyploid and aneuploid cells is consistent with a delay or arrest in the M phase of a substantial fraction of the cells expressing Tat, suggesting that mitotic spindle checkpoints are overridden following Tat expression. (c) 2005 Wiley-Liss, Inc. Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari Ematol, Policlin Umberto 1, I-00161 Rome, Italy; Ist Super Sanita, Lab Biol Cellulare, I-00161 Rome, Italy Gigliani, F (reprint author), Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari Ematol, Policlin Umberto 1, Viale Regina Elena,324, I-00161 Rome, Italy. gigliani@bce.uniroma1.it 34 4 4 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0886-1544 CELL MOTIL CYTOSKEL Cell Motil. Cytoskeleton JUL 2005 61 3 129 136 10.1002/cm.20070 8 Cell Biology Cell Biology 941DC WOS:000230193900001 J Cacchi, S; Fabrizi, G Cacchi, S; Fabrizi, G Synthesis and functionalization of Indoles through palladium-catalyzed reactions CHEMICAL REVIEWS English Review CROSS-COUPLING REACTIONS; SOLID-PHASE SYNTHESIS; HETEROAROMATIC RING-SYSTEMS; DIRECTED ORTHO-METALATION; CARBON BOND FORMATION; AMINOPALLADATION-REDUCTIVE ELIMINATION; ASSISTED INTRAMOLECULAR AMINATION; ANTITUMOR ANTIBIOTIC CC-1065; PI-ALLYLPALLADIUM COMPLEXES; INHIBITOR CARBAZOQUINOCIN-C Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy Cacchi, S (reprint author), Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, P A Moro 5, I-00185 Rome, Italy. sandro.cacchi@uniroma1.it 416 723 729 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0009-2665 CHEM REV Chem. Rev. JUL 2005 105 7 2873 2920 10.1021/cr040639b 48 Chemistry, Multidisciplinary Chemistry 945SQ WOS:000230522900006 J Campagna, F; Fioretti, F; Burattin, M; Romeo, S; Sentinelli, F; Bifolco, M; Sirinian, MI; Del Ben, M; Angelico, F; Arca, M Campagna, F; Fioretti, F; Burattin, M; Romeo, S; Sentinelli, F; Bifolco, M; Sirinian, MI; Del Ben, M; Angelico, F; Arca, M Congenital analbuminemia attributable to compound heterozygosity for novel mutations in the albumin gene CLINICAL CHEMISTRY English Article SPLICING MUTATION; DIAGNOSIS; FAMILY; RATS Univ Roma La Sapienza, Dept Clin & Appl Med Therapy, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Div Internal Med 4, I-00161 Rome, Italy Arca, M (reprint author), Univ Roma La Sapienza, Policlin Umberto I, Dipartimento Clin & Terapia Med Applicata, Viale Policlin 155, I-00161 Rome, Italy. marcelloarca@libero.it 20 15 15 AMER ASSOC CLINICAL CHEMISTRY WASHINGTON 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA 0009-9147 CLIN CHEM Clin. Chem. JUL 2005 51 7 1256 1258 10.1373/clinchem.2005.048561 3 Medical Laboratory Technology Medical Laboratory Technology 939VS WOS:000230101200025 J Chiesa, C; Osborn, JF; Pacifico, L; Tellan, G; Strappini, PM; Fazio, R; Delogu, G Chiesa, C; Osborn, JF; Pacifico, L; Tellan, G; Strappini, PM; Fazio, R; Delogu, G Circulating ghrelin in patients undergoing elective cholecystectomy CLINICAL CHEMISTRY English Article PLASMA GHRELIN; ACYLATED PEPTIDE; LEPTIN; RESPONSES; HUMANS; RATS Univ Roma La Sapienza, Dept Pediat, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Publ Hlth Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Anesthesia & Intens Care, I-00161 Rome, Italy; CNR, Rome, Italy Chiesa, C (reprint author), Univ Roma La Sapienza, Dept Pediat, Viale Regina Elena 324, I-00161 Rome, Italy. claudio.chiesa@uniroma1.it 20 6 6 AMER ASSOC CLINICAL CHEMISTRY WASHINGTON 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA 0009-9147 CLIN CHEM Clin. Chem. JUL 2005 51 7 1258 1261 10.1373/clinchem.2005.050104 4 Medical Laboratory Technology Medical Laboratory Technology 939VS WOS:000230101200026 J Tabolacci, E; Zollino, M; Lecce, R; Sangiorgi, E; Gurrieri, F; Leuzzi, V; Opitz, JM; Neri, G Tabolacci, E; Zollino, M; Lecce, R; Sangiorgi, E; Gurrieri, F; Leuzzi, V; Opitz, JM; Neri, G Two brothers with 22q13 deletion syndrome and features suggestive of the Clark-Baraitser syndrome CLINICAL DYSMORPHOLOGY English Article 22q13 deletion syndrome; Clark-Baraitser syndrome; X-linked mental retardation; multiple congenital anomalies syndrome; cryptic chromosome rearrangements LINKED MENTAL-RETARDATION; CHROMOSOMAL REARRANGEMENTS; OBESITY; FAMILY; XLMR We report on two brothers with moderate-to-severe mental retardation, severe macrocephaly, obesity, characteristic face, big hands and feet, advanced bone age and brain abnormalities, including frontal cortical atrophy. These two boys resembled the two brothers described by Clark and Baraitser (1987), two maternal cousins subsequently reported by Baraitser et al. (1995) and a Brazilian boy described by de Pina-Neto and Andreotti-de Molfetta (1998). Upon further investigation, we detected a cryptic subtelomeric deletion of chromosome region 22q13, not present in either parent and probably due to a maternal germinal mosaicism. Thus, we describe the first familial case of 22q13 deletion and recommend that patients with a phenotype suggestive of the so-called Clark-Baraitser syndrome be tested for submicroscopic 22qter deletion. Univ Sacred Heart, Inst Med Genet, I-00168 Rome, Italy; Univ Roma La Sapienza, Dept Neurol & Psychiat Sci, Rome, Italy; Univ Utah, Salt Lake City, UT USA Neri, G (reprint author), Univ Sacred Heart, Inst Med Genet, Largo F Vito 1, I-00168 Rome, Italy. gneri@rm.unicatt.it 17 5 6 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0962-8827 CLIN DYSMORPHOL Clin. Dysmorphol. JUL 2005 14 3 127 132 10.1097/00019605-200507000-00004 6 Genetics & Heredity Genetics & Heredity 950PC WOS:000230868400004 J Briganti, G; D'Arrigo, G; Maccarini, M; Pierleoni, C; Sterpone, F Briganti, G; D'Arrigo, G; Maccarini, M; Pierleoni, C; Sterpone, F Hydration and thermodynamic equilibrium of non-ionic surfactant in solution COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS English Article; Proceedings Paper International Workshop on Bubble and Drop Interfaces APR 25-28, 2004 Genoa, ITALY Italian Natl Res Council, Dept Inst energet & Interphase micellar interface; oligooxyethylene glycol; non-ionic surfactant aggregates MICELLAR SOLUTIONS; PHASE-BEHAVIOR; WATER In this article we present a combined analysis of volumetric [1] and molecular dynamics (MD) [2] determinations of the interfacial properties of non-ionic surfactant aggregates belonging to the family of the oligooxyethylene glycol (CiEj). The volumetric experiments were made on surfactant having i = 12 andj ranging from 5 to 8 EO unit and concern the density, and the sound velocity measurements on aqueous solutions of the surfactants. For concentrations up to about 40 wt.% the density of the solutions cross that of pure solvent at given temperatures. The presence of crossing temperatures T-rho allows us to describe the surfactant solutions in terms of an ideal mixture of pure solvent and an effective solute. On the ground of a simple hydration model for the micellar aggregate, we obtained the dependence of the degree of hydration and of the osmotic compressibility on the solute molar volumes and on the temperature. On the other hand, the compressibility embodies a term associated with a local osmotic exchange between the aggregates and the external solvent. To obtain a microscopic resolution of the interfacial properties. MD simulations were performed on a spherical C12E6 micelle. The dependence of the aggregate hydration on the temperature obtained by MD agrees with the results from density experiment. However, the MD clearly indicates that dehydration mainly occurs at the exposed hydrophobic area. Besides the MD results have shown that the micellar interface is characterized by significative interaction among the hydrophilic termination. These interactions leave a large hydrophobic area exposed to the solvent. Despite the complexity of the problem, in the context of our hydration model and within 40 wt.%, the properties of these solutions can be defined by their specific hydration numbers. (c) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, CRS, INFM, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, Dipartimento Energet, I-00185 Rome, Italy; Univ Heidelberg, Angew Phys Chem, D-69120 Heidelberg, Germany; Univ Aquila, INFM, Dipartimento Fis, I-67100 Laquila, Italy; Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA Briganti, G (reprint author), Univ Roma La Sapienza, CRS, INFM, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. giuseppe.briganti@romal.infn.it 16 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0927-7757 COLLOID SURFACE A Colloid Surf. A-Physicochem. Eng. Asp. JUL 1 2005 261 1-3 SI 93 99 10.1016/j.colsurfa.2004.11.037 7 Chemistry, Physical Chemistry 940RL WOS:000230161600011 J Ferri, M; Laghi, A; Mingazzini, P; Iafrate, F; Meli, L; Ricci, F; Passariello, R; Ziparo, V Ferri, M; Laghi, A; Mingazzini, P; Iafrate, F; Meli, L; Ricci, F; Passariello, R; Ziparo, V Pre-operative assessment of extramural invasion and sphincteral involvement in rectal cancer by magnetic resonance imaging with phased-array coil COLORECTAL DISEASE English Article rectal cancer; clinical staging; magnetic resonance inriaging; pre-operative radiotherapy; sphincter-saving surgery TOTAL MESORECTAL EXCISION; LOWER 3RD; CARCINOMA; MR; RADIOTHERAPY; RESECTION; ACCURACY; TOMOGRAPHY; SURGERY; TUMORS Objective: Pre-operative staging of rectal cancer should identify patients with extrarectal spread, who might benefit from pre-operative radiotherapy, and patients with minimal sphincteral involvement, who can avoid permanent colostomy. The aim of this study was to assess the accuracy of Magnetic Resonance Imaging (MRI) to predict turnout stage and sphincter status. Patients and methods: Thirty-three patients with a rectal tumour were pre-operatively assessed by MRI with a phased-array coil. Imaging results were correlated with the final pathological findings. Results: The overall accuracy of pre-operative staging with MRI was 88% (k = 0.75) for extramural tumour invasion and 59% (k = 0.26) for lymph node metastases. MRI correctly evaluated the infiltration of the anal sphincters in 87% of patients (7 of 8 patients with low rectal tumour). Conclusion: MRI provides the surgeon with valuable information regarding extramural tumour spread and sphincteral involvement, enabling appropiate selection of patients for pre-operative adjuvant therapy or sphincter-saving sugery. Univ Roma La Sapienza, Dept Surg P Valdoni, Rome, Italy; Univ Roma La Sapienza, Dept Radiol Sci, Rome, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy Ferri, M (reprint author), Via Cors 4, I-00198 Rome, Italy. mario.ferri@uniroma1.it Laghi, Andrea/A-2343-2011 27 16 16 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1462-8910 COLORECTAL DIS Colorectal Dis. JUL 2005 7 4 387 393 10.1111/j.1463-1318.2005.00787.x 7 Gastroenterology & Hepatology Gastroenterology & Hepatology 975GH WOS:000232648500017 J Gentile, G; Gallavotti, G Gentile, G; Gallavotti, G Degenerate elliptic resonances COMMUNICATIONS IN MATHEMATICAL PHYSICS English Article QUASI-PERIODIC SOLUTIONS; LOWER-DIMENSIONAL TORI; NONLINEAR-WAVE EQUATIONS; INTEGRABLE HAMILTONIAN-SYSTEMS; RENORMALIZATION-GROUP; SCHRODINGER-EQUATION; LINDSTEDT SERIES; INVARIANT TORI; KAM TORI; PERTURBATIONS Quasi-periodic motions on invariant tori of an integrable system of dimension smaller than half the phase space dimension may continue to exist after small perturbations. The parametric equations of the invariant tori can often be computed as a formal power series in the perturbation parameter and can be given a meaning via resummations. Here we prove that, for a class of elliptic tori, a resummation algorithm can be devised and proved to be convergent, thus extending to such lower-dimensional invariant tori the methods employed to prove convergence of the Lindstedt series either for the maximal (i.e. KAM) tori or for the hyperbolic lower-dimensional invariant tori. Univ Roma Tre, Dipartimento Matemat, I-00146 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Gentile, G (reprint author), Univ Roma Tre, Dipartimento Matemat, I-00146 Rome, Italy. Gentile, Guido/G-9383-2012 44 16 16 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0010-3616 COMMUN MATH PHYS Commun. Math. Phys. JUL 2005 257 2 319 362 10.1007/s00220-005-1325-6 44 Physics, Mathematical Physics 927ZN WOS:000229241000006 J Atzeni, S; Schiavi, A; Califano, F; Cattani, F; Cornolti, F; Del Sarto, D; Liseykina, TV; Macchi, A; Pegoraro, F Atzeni, S; Schiavi, A; Califano, F; Cattani, F; Cornolti, F; Del Sarto, D; Liseykina, TV; Macchi, A; Pegoraro, F Fluid and kinetic simulation of inertial confinement fusion plasmas COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Computational Physics SEP 01-04, 2004 Genoa, ITALY inertial confinement fusion (ICF); lagrangian fluid codes; Rayleigh-Taylor instability; laser-plasma interaction; PIC codes; fast ignitor; weibel instability NATIONAL IGNITION FACILITY; LASER FUSION; PROTON-BEAMS; TARGETS; PHYSICS; INSTABILITY; DENSITY; PULSES; SCHEME; FUEL The main features of codes for inertial confinement fusion studies are outlined, and a few recent simulation results are presented. The two-dimensional Lagrangian fluid code DUED is used to study target evolution, including beam-driven compression, hydrodynamic stability, hot spot formation, ignition and burn. An electro-magnetic particle-in-cell (PIC) code is applied to the study of ultraintense laser-plasma interaction and generation of fast electron jets. A relativistic 3D collisionless fluid model addresses relativistic electron beam propagation in a dense plasma. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Energet, Rome, Italy; Univ Pisa, Dipartimento Fis E Fermi, Pisa, Italy; Univ Pisa, INFM, Pisa, Italy Atzeni, S (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Piazzale Aldo Moro 5, Rome, Italy. stefano.atzeni@uniromal.it Macchi, Andrea/B-1900-2009; Liseykina, Tatyana/B-1229-2009; Atzeni, Stefano/F-5538-2012 Macchi, Andrea/0000-0002-1835-2544; 34 33 33 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 153 159 10.1016/j.cpc.2005.03.036 7 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100035 J Sciortino, F; Buldyrev, SV; De Michele, C; Foffi, G; Ghofraniha, N; La Nave, E; Moreno, A; Mossa, S; Saika-Voivod, I; Tartaglia, P; Zaccarelli, E Sciortino, F; Buldyrev, SV; De Michele, C; Foffi, G; Ghofraniha, N; La Nave, E; Moreno, A; Mossa, S; Saika-Voivod, I; Tartaglia, P; Zaccarelli, E Routes to colloidal gel formation COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Computational Physics SEP 01-04, 2004 Genoa, ITALY gels; glasses; colloids POLYMER MIXTURES; PHASE-BEHAVIOR; GLASS-TRANSITION; SYSTEM; DIAGRAMS; MODEL We discuss features of simple inter-particle potentials which are able to generate low-packing fraction arrested states, i.e. gels, in the absence of a macroscopic phase separation phenomenon. We suggest that the ratio between surface and bulk free energy is crucial in favoring ideal gel states. Two possible models for gels, one based on the competition of short range attraction and long range repulsions and the other on local constraints disfavoring packed local structures are discussed. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, CRS, SOFT, I-00185 Rome, Italy; Yeshiva Univ, Dept Phys, New York, NY 10033 USA; European Synchrotron Radiat Facil, F-38043 Grenoble, France; Univ Roma La Sapienza, INFM, CRS, SMC, I-00185 Rome, Italy Sciortino, F (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 5, I-00185 Rome, Italy. francesco.sciortino@phys.uniromal.it Saika-Voivod, Ivan/D-1249-2009; Moreno, Angel/C-7313-2011; Tartaglia, Piero/F-2194-2011; Sciortino, Francesco/B-4768-2012; Foffi, Giuseppe/C-3923-2009; Emanuela, Zaccarelli/K-4695-2013 35 27 27 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 166 171 10.1016/j.cpc.2005.03.038 6 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100037 J Bonella, S; Coker, D Bonella, S; Coker, D Linearized, time-dependent, non-adiabatic quantum correlation functions COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Compuitational Physics SEP 01-04, 2004 Genova, ITALY non-adiabatic dynamics; linearized path integral; mapping Hamiltonian; quantum time correlation functions INITIAL-VALUE REPRESENTATION; VIBRATIONAL-ENERGY RELAXATION; MAPPING HAMILTONIAN APPROACH; COMPLEX MOLECULAR-SYSTEMS; SEMICLASSICAL DESCRIPTION; ELECTRONIC DEGREES; CONDENSED-PHASE; DYNAMICS; EQUATION; FREEDOM A new approximate method for the calculation of quantum time correlation functions is derived. The new theory combines the linearized path integral approach and the mapping Hamiltonian formulation so that time correlation functions can be calculated for systems in which non-adiabatic electronic transitions are important. (c) 2005 Elsevier B.V. All rights reserved. Boston Univ, Dept Chem, Boston, MA 02215 USA Coker, D (reprint author), Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA. sbonella@bu.edu; coker@bu.edu 26 4 4 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 267 273 10.1016/j.cpc.2005.03.061 7 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100059 J Capuzzo-Dolcetta, R Capuzzo-Dolcetta, R High performance computing for self-gravitating systems COMPUTER PHYSICS COMMUNICATIONS English Article; Proceedings Paper Europhysics Conference on Compuitational Physics SEP 01-04, 2004 Genova, ITALY self-gravitating systems; stellar and galactic systems; supercomputing SOLAR-SYSTEM; SIMULATIONS; EVOLUTION A peculiarity of astrophysics with respect to terrestrial physics is the unavoidable presence of self-gravity. This makes astrophysical simulations very hard to be done, because self-gravity induces, by mean of the fine grain structure superposed to the coarse grain, a multitude of space and time scales. In this report I give (i) a brief overview of the simulation problems to be faced in astrophysics and cosmology, with particular emphasis on the classic gravitational N-body problem and (ii) some results on the evolution of a typical example of intermediate N-body system, like a globular cluster moving in an external galactic field. (c) 2005 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy Capuzzo-Dolcetta, R (reprint author), Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy. dolcetta@uniroma1.it 13 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0010-4655 COMPUT PHYS COMMUN Comput. Phys. Commun. JUL 1 2005 169 1-3 365 369 10.1016/j.cpc.2005.03.081 5 Computer Science, Interdisciplinary Applications; Physics, Mathematical Computer Science; Physics 945UQ WOS:000230528100079 J Grimaldi, B; de Raaf, MA; Filetici, P; Ottonello, S; Ballario, P Grimaldi, B; de Raaf, MA; Filetici, P; Ottonello, S; Ballario, P Agrobacterium-mediated gene transfer and enhanced green fluorescent protein visualization in the mycorrhizal ascomycete Tuber borchii: a first step towards truffle genetics CURRENT GENETICS English Article mycorrhizal fungi; Tuber borchii; truffles; Agrobacterium tumefaciens; genetic transformation; EGFP AGARICUS-BISPORUS; NEUROSPORA-CRASSA; HYGROMYCIN-B; TRANSFORMATION; TUMEFACIENS; SEQUENCE; FUNGI; BODY Mycorrhizal ascomycetes are ecologically and commercially important fungi that have proved impervious to genetic transformation so far. We report here on the successful transient transformation of Tuber borchii, an ectomycorrhizal ascomycete that colonizes a variety of trees and produces highly prized hypogeous fruitbodies known as "truffles". A hypervirulent Agrobacterium tumefaciens strain bearing the binary plasmid pBGgHg was used for transformation. The genes for hygromycin resistance and the enhanced green fluorescent protein (EGFP), both under the control of vector-borne promoters, were employed as selection markers. Patches of dark and fluorescent hyphae were observed upon fluorescence microscopic examination of hygromycin-resistant mycelia. The presence of EGFP was confirmed by both confocal microscopy and PCR analysis. The lack in the transformed mycelia of the DNA coding for kanamicin resistance (a trait encoded by a vector-borne gene located outside of the T-DNA region) indicates that Agrobacterium-mediated gene transfer correctly occurred in T. borchii. Univ Roma La Sapienza, Ist Biol & Patol Mol, CNR, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; Avans Hogesch, Dept Life Sci, Breda, Netherlands; Univ Parma, Dipartimento Biochim & Biol Mol, I-43100 Parma, Italy Ballario, P (reprint author), Univ Roma La Sapienza, Ist Biol & Patol Mol, CNR, P Aldo Moro 5, I-00185 Rome, Italy. paola.ballario@uniroma1.it 16 21 24 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0172-8083 CURR GENET Curr. Genet. JUL 2005 48 1 69 74 10.1007/s00294-005-0579-z 6 Genetics & Heredity Genetics & Heredity 947DW WOS:000230624600006 J Laviano, A; Muscaritoli, M; Cascino, A; Preziosa, I; Inui, A; Mantovani, G; Rossi-Fanelli, F Laviano, A; Muscaritoli, M; Cascino, A; Preziosa, I; Inui, A; Mantovani, G; Rossi-Fanelli, F Branched-chain amino acids: the best compromise to achieve anabolism? CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE English Article anorexia; branched-chain amino acids; cachexia; leucine; wasting HYDROXY-BETA-METHYLBUTYRATE; ANOREXIA-CACHEXIA SYNDROME; GASTRIC-CANCER PATIENTS; TUMOR-BEARING RATS; QUALITY-OF-LIFE; SKELETAL-MUSCLE; MEGESTROL-ACETATE; NUTRITIONAL SUPPLEMENTATION; ORAL SUPPLEMENTATION; PARENTERAL-NUTRITION Purpose of review The anorexia-cachexia syndrome is highly prevalent in patients suffering from acute and chronic diseases, including cancer, chronic renal failure and liver cirrhosis. Once it has developed, it significantly influences the clinical course of the underlying disease, simultaneously impinging on patients' quality of life. Unfortunately, currently available therapeutic strategies do not appear to greatly impact on patients' morbidity, mortality and quality of life. More effective therapies are needed to promote appetite and food intake, to preserve lean body mass, and to ameliorate patients' psychological distress. Recent findings Branched-chain amino acids are neutral amino acids with interesting and clinically relevant metabolic effects. Their potential role as antianorexia and anticachexia agents was proposed many years ago, but only recent experimental studies and clinical trials have tested their ability to stimulate food intake and counteract muscle wasting in anorectic, weight-losing patients. By interfering with brain serotonergic activity and by inhibiting the overexpression of critical muscular proteolytic pathways, branched-chain amino acids have been shown to induce beneficial metabolic and clinical effects under different pathological conditions. Summary Based on the available data, branched-chain amino acids appear to exert significant antianorectic and anticachectic effects, and their supplementation may represent a viable intervention not only for patients suffering from chronic diseases, but also for those individuals at risk of sarcopenia due to age, immobility or prolonged bed rest, including trauma, orthopedic or neurologic patients. Univ Roma La Sapienza, Dept Clin Med, I-00185 Rome, Italy; Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Behav Med, Kagoshima 890, Japan; Univ Cagliari, Dept Med Oncol, Cagliari, Italy Laviano, A (reprint author), Univ Roma La Sapienza, Dept Clin Med, Viale Univ 37, I-00185 Rome, Italy. alessandro.laviano@uniroma1.it 48 40 42 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA 1363-1950 CURR OPIN CLIN NUTR Curr. Opin. Clin. Nutr. Metab. Care JUL 2005 8 4 408 414 10.1097/01.mco.0000172581.79266.19 7 Endocrinology & Metabolism; Nutrition & Dietetics Endocrinology & Metabolism; Nutrition & Dietetics 976IZ WOS:000232728200011 J de Angelis, L; Zhao, JH; Andreucci, JJ; Olson, EN; Cossu, G; McDermott, JC de Angelis, L; Zhao, JH; Andreucci, JJ; Olson, EN; Cossu, G; McDermott, JC Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway DEVELOPMENTAL BIOLOGY English Article p38 MAPK; MEF2; muscle regulatory factors TRANSCRIPTION FACTOR MEF2; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; GENE-EXPRESSION; MOUSE EMBRYOGENESIS; PARAXIAL MESODERM; MYOGENIN GENE; CELL-GROWTH; MYF-5; DIFFERENTIATION Biochemical and cell culture studies have characterized the myocyte enhancer factor 2 (MEF2) transcriptional regulatory proteins as obligatory partners for the myogenic regulatory factors (MRFs) in the differentiation of myogenic cells in culture. However, the role of MEF2 activation in somitic myogenesis has not been fully characterized. Here, we report a critical interaction between the p38 mitogen-activated protein kinase (p38 MAPK) and MEF2 in the developing somite myotome. We document expression of MEF2A and p38 MAPK proteins in the somite of 9.5 dpc mouse embryos concurrent with Myf 5 protein expression. We also observed that abrogation of p38 MAPK signaling blocks MEF2 activation using a MEF2 transgenic 'sensor' mouse. Inhibition of p38 MAPK signaling concurrently inhibited myogenic differentiation in somite cultures and in embryos in vivo using transplacental injection of a p38 inhibitor (SB203580). Finally, we document that commitment to the myogenic lineage is not appreciably affected by p38 MAPK inhibition since the activation of an early marker of myogenic commitment (Myf 5) occurs normally when p38 MAPK signaling is inhibited. Thus, we present novel evidence indicating a crucial role for p38 MAPK signaling to the MEF2 transcriptional regulators during early mammalian somite development and myotome formation. (C) 2005 Elsevier Inc. All rights reserved. York Univ, Dept Biol, N York, ON M3J 1P3, Canada; Univ Roma La Sapienza, Ist Istol & Embriol Gen, I-00161 Rome, Italy; Univ Texas, SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA; DIBITH San Raffaele, Stem Cell Res Inst, I-20132 Milan, Italy McDermott, JC (reprint author), York Univ, Dept Biol, 4700 Keele St, N York, ON M3J 1P3, Canada. jmcderm@yorku.ca 56 45 47 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0012-1606 DEV BIOL Dev. Biol. JUL 1 2005 283 1 171 179 10.1016/j.ydbio.2005.04.009 9 Developmental Biology Developmental Biology 944HR WOS:000230418400013 J Ishii, H; Mimori, K; Mori, M; Vecchione, A Ishii, H; Mimori, K; Mori, M; Vecchione, A Differentially expressed genes in endothelial differentiation DNA AND CELL BIOLOGY English Article IDENTIFICATION; ANGIOGENESIS; CANCER; LOCALIZATION; BLADDER; RING3 By screening differentially expressed genes in mouse embryonic stem (ES) cells by subtractive hybridization, we identified three conserved but uncharacterized genes encoding bromodomain containing 3 (BRD3), protein lysine methyltransferase (PLM), and kelch domain containing 2 (KLHDC2), which were downregulated during endothelial differentiation. An RNA blot study showed that these genes were markedly expressed in undifferentiated ES cells, whereas the expression was reduced upon endothelial differentiation; a study of mouse endothelium showed a significant reduction in the expression of BRD3. A study of human BRD3, located on chromosome 9 at q34, a region susceptible to genomic rearrangement, showed an altered expression in 4 of 12 patients with bladder cancer, compared with adjacent noncancerous tissues. Taken together with the result of siRNA inhibition showing the positive regulation of cell proliferation by BRD3, it is suggested that this molecule plays a role in allowing cells to enter the proliferative phase of the angiogenic process. Jichi Med Sch, Ctr Mol Med, Minami Kawachi, Tochigi 3290498, Japan; Kyushu Univ, Inst Bioregulat, Ohita, Japan; Univ Roma La Sapienza, Fac Med 2, Hosp Santo Andrea, Div Pathol, Rome, Italy Ishii, H (reprint author), Jichi Med Sch, Ctr Mol Med, Minami Kawachi, Tochigi 3290498, Japan. hishii@ms.jichi.ac.jp 16 2 5 MARY ANN LIEBERT INC NEW ROCHELLE 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA 1044-5498 DNA CELL BIOL DNA Cell Biol. JUL 2005 24 7 432 437 10.1089/dna.2005.24.432 6 Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity 946QD WOS:000230586300003 J D'Amelio, R; Mele, A; Mariano, A; Romano, L; Biselli, R; Lista, F; Zanetti, A; Stroffollini, T D'Amelio, R; Mele, A; Mariano, A; Romano, L; Biselli, R; Lista, F; Zanetti, A; Stroffollini, T Hepatitis A, Italy EMERGING INFECTIOUS DISEASES English Letter Univ Roma La Sapienza, Osped S Andrea, Fac Med & Chirurg 2, I-00189 Rome, Italy; Direz Gen Sanite Mil, Rome, Italy; Ist Super Sanita, I-00161 Rome, Italy; Univ Milan, Ist Virol, Milan, Italy; Ctr Sperimentale Volo, Pratica Di Mare, Italy; Ctr Studie & Ric Sanita & Vet, Rome, Italy; Osped S Giacomo, Rome, Italy D'Amelio, R (reprint author), Univ Roma La Sapienza, Osped S Andrea, Fac Med & Chirurg 2, Via Grottarossa 1039, I-00189 Rome, Italy. raffaele.damelio@ospedalesantandrea.it 6 12 12 CENTER DISEASE CONTROL ATLANTA ATLANTA, GA 30333 USA 1080-6040 EMERG INFECT DIS Emerg. Infect. Dis JUL 2005 11 7 1155 1156 2 Immunology; Infectious Diseases Immunology; Infectious Diseases 939XS WOS:000230106600041 J Sciubba, E; Ulgiati, S Sciubba, E; Ulgiati, S Emergy and exergy analyses: Complementary methods or irreducible ideological options? ENERGY English Article The paper discusses the similarities and the incompatibilities between two forms of Energy Analysis (exergy and emergy, 'EXA' and 'EMA' in the following), both of which try to represent the behavior of physical systems by means of cumulative energy input/output methods that result in a double integration over space and. time domains. Theoretical background, definitions and balance algebra are discussed first, in a 'statement-counterstatement' format that helps pinpointing differences and similarities. A significant, albeit simplified, benchmark case (ethanol production from corn) is used to compare the results and analytically assess the merits of each approach as well as possible synergic aspects. Corn production, transport and industrial conversion to ethanol are included in the analysis. First, mass balance and energy accounting are performed in each step of the process, then, exergy and emergy evaluations are carried out separately to lead to a set of performance indicators, the meaning of which is discussed with reference to their proper scale of application. The Authors underline that each method has its own preferred field of application and conclude that the two approaches appear to be characterized not much as different (and therefore 'competing) tools, but as different paradigms, whose meta-levels (their 'philosophies') substantially differ. In particular, EXA is found to provide the most correct and insightful assessment of thermodynamic features of any process and to offer a clear quantitative indication of both the irreversibilities and the degree of matching between the used resources and the end-use material or energy flows. EXA combined with costing considerations results in Thermo-Economics (TE), presently the best engineering method for System optimization. One of EXA recent extensions, Extended Exergy Accounting (EEA) includes all externalities in the exergy resource accounting, thus providing a more complete picture of how a process is interacting with its socio-economical environment and with the Biosphere. EMA further expands the evaluation to the larger scale of the Biosphere and properly accounts for the globality of the energy and resource flows supporting complex living systems. Although some conceptual assumptions and methodological differences appear irreconcilable, important similarities are also found that may lead to further methodological and practical convergences. Note: Although a significant confrontation and debate accompanied the development of this paper, contrasting opinions about important features of the two approaches still exist. Therefore, SU takes full responsibility of statements in Sections 2,4.1, 6.2, 7.1 while ES takes full responsibility of statements in Sections 3,4.2, 6.1, 7.2. All remaining Sections reflect points of view agreed upon by both Authors. © 2004 Elsevier Ltd. All rights reserved. Univ Rome 1, Dept Mech & Aeronaut Engn, I-00184 Rome, Italy; Univ Siena, Dept Chem, I-53100 Siena, Italy Sciubba, E (reprint author), Univ Rome 1, Dept Mech & Aeronaut Engn, Via Eudossiana 18, I-00184 Rome, Italy. enrico.sciubba@uniroma1.it 65 81 85 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0360-5442 ENERGY Energy JUL 2005 30 10 1953 1988 10.1016/j.energy.2004.08.003 36 Thermodynamics; Energy & Fuels Thermodynamics; Energy & Fuels 927BQ WOS:000229167800019 J Tomei, MC; Annesini, MC Tomei, MC; Annesini, MC 4-mitrophenol biodegradation in a sequencing batch reactor operating with aerobic-anoxic cycles ENVIRONMENTAL SCIENCE & TECHNOLOGY English Article P-NITROPHENOL; 4-NITROPHENOL BIODEGRADATION; DEGRADATION; REMOVAL; KINETICS; MODEL The study regards 4-nitrophenol removal performed in a lab-scale sequential batch reactor with an integrated aerobic-anoxic cycle. The purpose of the study was to examine the kinetics of 4-nitrophenol biological oxidation and denitrification in order to test the feasibility of the proposed technological solution for xenobiotic removal. The results obtained showthat high removal efficiency of 4-nitrophenol is easily achieved when the compound is fed into the reactor as the sole carbon source. Residual concentrations of 4-nitrophenol and nitrous/nitric nitrogen in the effluent lower than 1 mg L-1 were observed in the range of applied feed concentration (200-320 mg L-1). Low concentrations of dissolved oxygen (<= 2 mg L-1) in the feed and aerobic phases lead to appreciable simultaneous denitrification. As regards the denitrification process, while no carbon limiting effects were observed at COD/N ratios >= 3, a significant decrease in the rate of denitrification is detected for COD/N ratios <= 2. The denitrification rate obtained in tests with no external carbon addition proved very low and unsuitable for practical application. A model of the denitrification process taking into account both the limiting effect of nitrogen and carbonaceous substrate has been proposed and applied for experimental data correlation. CNR, Water Res Inst, I-00198 Rome, Italy; Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy Tomei, MC (reprint author), CNR, Water Res Inst, Via Reno 1, I-00198 Rome, Italy. tomei@irsa.cnr.it 21 30 30 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0013-936X ENVIRON SCI TECHNOL Environ. Sci. Technol. JUL 1 2005 39 13 5059 5065 10.1021/es0483140 7 Engineering, Environmental; Environmental Sciences Engineering; Environmental Sciences & Ecology 941WS WOS:000230245500061 J Di Bonaventura, C; Vaudano, AE; Carni, M; Pantano, P; Nucciarelli, V; Garreffa, G; Maraviglia, B; Prencipe, M; Bozzao, L; Manfredi, M; Giallonardo, AT Di Bonaventura, C; Vaudano, AE; Carni, M; Pantano, P; Nucciarelli, V; Garreffa, G; Maraviglia, B; Prencipe, M; Bozzao, L; Manfredi, M; Giallonardo, AT Long-term reproducibility of fMRI activation in epilepsy patients with fixation off sensitivity EPILEPSIA English Letter EEG Univ Roma La Sapienza, Dept Neurol Sci, Epilepsy Unit, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy; Univ Roma La Sapienza, Neuromed Inst Pozzilli, I-00185 Rome, Italy; Enrico Fermi Ctr, Rome, Italy Di Bonaventura, C (reprint author), Univ Roma La Sapienza, Dept Neurol Sci, Epilepsy Unit, Viale Univ 30, I-00185 Rome, Italy. c_dibonaventura@yahoo.it Patrizia, Pantano/C-8214-2009; Garreffa, Girolamo/F-4204-2010 Garreffa, Girolamo/0000-0002-2678-6692 9 10 10 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0013-9580 EPILEPSIA Epilepsia JUL 2005 46 7 1149 1151 10.1111/j.1528-1167.2005.11005.x 3 Clinical Neurology Neurosciences & Neurology 944LZ WOS:000230431800022 J Quaglione, R; Calcagnini, G; Censi, F; Malavasi, M; Raveggi, M; Biancalana, G; Bartolini, P; Critelli, G Quaglione, R; Calcagnini, G; Censi, F; Malavasi, M; Raveggi, M; Biancalana, G; Bartolini, P; Critelli, G Effect of pacemaker rate-adaptation on 24h beat-to-beat heart rate and blood pressure profiles EUROPACE English Article heart rate; blood pressure; rate-responsive pacing SYMPATHETIC-NERVE ACTIVITY; CLOSED-LOOP STIMULATION; INTRACARDIAC IMPEDANCE; SINGLE-CHAMBER; VVI; VARIABILITY; BENEFIT; SIGNAL; BLIND Aims The aims of the study were to evaluate the 24-h beat-to-beat heart rate (RR) and blood pressure changes during closed loop stimulation (DDDCLS) pacing and conventional fixed rate DDD pacing with respect to spontaneous activity. Methods We simultaneously and continuously measured beat-to-beat heart rate and blood pressure for 24 h in patients implanted with Inos(2+) (Biotronik GmbH, Berlin, Germany). A randomised cross-over comparison of DDD-CLS and DDD pacing was performed by short- and long-term analyses. Results Seventeen patients (10 mates, aged 46-85 years) were enroled in the study: 11 completed the protocol. The percentage of atrial stimulation was 72.87% during DDD-CLS and 38.36% in DDD (P = 0.003). All patients were 100% stimulated in the ventricle. On average, the percentage increase of paced RR intervals with respect to spontaneous beats was only 7.4% in DDD-CLS but 20.1% in DDD (P = 0.0001). A significant correlation between spontaneous and paced RR profiles was obtained only during DDD-CLS (r(DDD-CLS) = 0.77, r(DDD) = 0.23, P = 0.01). Shortterm analysis revealed a 3.79% reduction of the escape interval in DDD-CLS and 8.19% in DDD, and the relative fall in diastolic blood pressure was 1.14% in DDD-CLS and 3.81% in DDD. Conclusion DDD-CLS provided physiological heart rate fluctuations throughout the 24-h test. The blood pressure profiles of paced and spontaneous beats were comparable. The onset of paced rhythm in DDD-CLS resulted in a less pronounced decrease in heart rate and fall in diastolic pressure than in DDD. (c) 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved. Ist Super Sanita, Dept Technol & Hlth, I-00161 Rome, Italy; Univ Roma La Sapienza, Inst Heart & Great Vessels, Rome, Italy; Biotron Seda, Milan, Italy Calcagnini, G (reprint author), Ist Super Sanita, Dept Technol & Hlth, Viale Regina Elena 299, I-00161 Rome, Italy. giovanni.calagnini@iss.it 23 7 7 W B SAUNDERS CO LTD LONDON 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND 1099-5129 EUROPACE Europace JUL 2005 7 4 366 373 10.1016/j.eupc.2005.03.005 8 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 941YX WOS:000230251200008 J Marchetti, DJ; Nucci, F Marchetti, DJ; Nucci, F Price stickiness and the contractionary effect of technology shocks EUROPEAN ECONOMIC REVIEW English Article technology shocks; price stickiness; business cycle MONETARY-POLICY RULES; BUSINESS-CYCLE; PANEL-DATA; ESTIMATORS; SCALE; SPECIFICATION; REGRESSIONS; EMPLOYMENT; RETURNS; OUTPUT We derive a measure of technological change from a dynamic cost minimization model that controls for imperfect competition, increasing returns and unobserved factor utilization. We estimate this measure using highly detailed panel data of a representative sample of Italian manufacturing firms for the period 1984-1997. Our key finding is that technological improvements result in a contraction of labor input on impact. In principle, this result can be reconciled with the transmission mechanism of flexible-price models by resorting to reorganization and reallocation effects. On the other hand, however, it is consistent with the predictions of a sticky-price model. Using survey information on the frequency of price revisions, we corroborate the latter interpretation, by showing that the contractionary effect of technology shocks is much stronger for firms with stickier prices. (c) 2003 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Fac Sci Stat, I-00185 Rome, Italy; Bank Italy, Dept Res, I-00184 Rome, Italy Nucci, F (reprint author), Univ Roma La Sapienza, Fac Sci Stat, Ple A Moro 5, I-00185 Rome, Italy. francesco.nucci@uniroma1.it 37 12 12 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0014-2921 EUR ECON REV Eur. Econ. Rev. JUL 2005 49 5 1137 1163 10.1016/j.euroecorev.2003.08.012 27 Economics Business & Economics 929QL WOS:000229360700004 J Abbate, A; Biondi-Zoccai, GGL Abbate, A; Biondi-Zoccai, GGL The difficult task of glycaemic control in diabetics with acute coronary syndromes: finding the way to normoglycaemia avoiding both hyper- and hypoglycaemia EUROPEAN HEART JOURNAL English Editorial Material ACUTE MYOCARDIAL-INFARCTION; STRESS HYPERGLYCEMIA; GLUCOSE; INSULIN; APOPTOSIS; MORTALITY; ISCHEMIA; MELLITUS; RISK Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23233 USA; Univ Hosp St Rafael, Intervent Cardiol Unit, Milan, Italy Abbate, A (reprint author), Virginia Commonwealth Univ, Dept Internal Med, 10025 Bellona Court, Richmond, VA 23233 USA. abbatea@yahoo.com Abbate, Antonio/C-2388-2008 15 6 6 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0195-668X EUR HEART J Eur. Heart J. JUL 2005 26 13 1245 1248 10.1093/eurheartj/ehi230 4 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 943WD WOS:000230384700001 J Breccia, M; D'Andrea, M; Alimena, G Breccia, M; D'Andrea, M; Alimena, G Can nifedipine and estrogen interaction with imatinib be responsible for gallbladder stone development? EUROPEAN JOURNAL OF HAEMATOLOGY English Letter Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy Breccia, M (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Via Benevento 6, Rome, Italy. breccia@bce.uniroma1.it 4 2 2 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0902-4441 EUR J HAEMATOL Eur. J. Haematol. JUL 2005 75 1 89 90 10.1111/j.1600-0609.2005.00476.x 2 Hematology Hematology 932VE WOS:000229581400016 J Wood, ET; Stover, DA; Ehret, C; Destro-Bisol, GD; Spedini, G; McLeod, H; Louie, L; Bamshad, M; Strassmann, BI; Soodyall, H; Hammer, MF Wood, ET; Stover, DA; Ehret, C; Destro-Bisol, GD; Spedini, G; McLeod, H; Louie, L; Bamshad, M; Strassmann, BI; Soodyall, H; Hammer, MF Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes EUROPEAN JOURNAL OF HUMAN GENETICS English Article mtDNA; Y chromosome; human; Africa; language; geography; correlation; evolution; Mantel SUB-SAHARAN AFRICA; HUMAN-POPULATIONS; HAPLOTYPES; AFFINITIES; ORIGINS; MITOCHONDRIAL; DIVERSITY; MIGRATION; EUROPE; POLYMORPHISMS To investigate associations between genetic, linguistic, and geographic variation in Africa, we type 50 Y chromosome SNPs in 1122 individuals from 40 populations representing African geographic and linguistic diversity. We compare these patterns of variation with those that emerge from a similar analysis of published mtDNA HVS1 sequences from 1918 individuals from 39 African populations. For the Y chromosome, Mantel tests reveal a strong partial correlation between genetic and linguistic distances (r = 0.33, P = 0.001) and no correlation between genetic and geographic distances ( r = -0.08, P > 0.10). In contrast, mtDNA variation is weakly correlated with both language (r = 0.16, P = 0.046) and geography (r = 0.17, P = 0.035). AMOVA indicates that the amount of paternal among-group variation is much higher when populations are grouped by linguistics (Phi(CT) = 0.21) than by geography (Phi(CT) = 0.06). Levels of maternal genetic among-group variation are low for both linguistics and geography (Phi(CT) = 0.03 and 0.04, respectively). When Bantu speakers are removed from these analyses, the correlation with linguistic variation disappears for the Y chromosome and strengthens for mtDNA. These data suggest that patterns of differentiation and gene flow in Africa have differed for men and women in the recent evolutionary past. We infer that sex-biased rates of admixture and/or language borrowing between expanding Bantu farmers and local hunter-gatherers played an important role in influencing patterns of genetic variation during the spread of African agriculture in the last 4000 years. Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA; Univ Arizona, Div Biotechnol, Tucson, AZ 85721 USA; Univ Calif Los Angeles, Dept Hist, Los Angeles, CA 90024 USA; Univ Roma La Sapienza, Dept Anim & Human Biol, Rome, Italy; Washington Univ, Dept Med, St Louis, MO USA; Childrens Hosp Oakland, Oakland, CA 94609 USA; Univ Utah, Salt Lake City, UT USA; Univ Michigan, Dept Anthropol, Ann Arbor, MI 48109 USA; Univ Witwatersrand, Human Genom Divers & Dis Res Unit, Johannesburg, South Africa Hammer, MF (reprint author), Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA. mfh@u.arizona.edu 47 93 94 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 1018-4813 EUR J HUM GENET Eur. J. Hum. Genet. JUL 2005 13 7 867 876 10.1038/sj.ejhg.5201408 10 Biochemistry & Molecular Biology; Genetics & Heredity Biochemistry & Molecular Biology; Genetics & Heredity 938CJ WOS:000229977200013 J Chekanov, S; Derrick, M; Magill, S; Miglioranzi, S; Musgrave, B; Repond, J; Yoshida, R; Mattingly, MCK; Pavel, N; Yagues, AG; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romeo, GC; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Margotti, A; Montanari, A; Nania, R; Palmonari, F; Pesci, A; Polini, A; Rinaldi, L; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Irrgang, P; Jakob, HP; Kind, OM; Meyer, U; Paul, E; Rautenberg, J; Renner, R; Voss, KC; Wang, M; Wlasenko, M; Bailey, DS; Brook, NH; Cole, JE; Heath, GP; Namsoo, T; Robins, S; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, JY; Ma, KJ; Helbich, M; Ning, Y; Ren, Z; Schmidke, WB; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Szuba, D; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Kowal, AM; Lukasik, J; Przybycien, M; Suszycki, L; Szuba, J; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Borras, K; Drews, G; Fourletova, J; Geiser, A; Gladkov, D; Gottlicher, PG; Gutsche, O; Haas, T; Hain, W; Horn, C; Kahle, B; Kotz, U; Kowalski, H; Kramberger, G; Lelas, D; Lim, H; Lohr, B; Mankel, R; Melzer-Pellman, IA; Nguyen, CN; Notz, D; Nuncio-Quiroz, AE; Raval, A; Santamarta, R; Schneekloth, U; Stadie, H; Stosslein, U; Wolf, G; Youngman, C; Zeuner, W; Schlenstedt, S; Barbagli, G; Gallo, E; Genta, C; Pelfer, PG; Bamberger, A; Benen, A; Karstens, F; Dobur, D; Vlasov, NN; Bussey, PJ; Doyle, AT; Dunne, W; Ferrando, J; Hamilton, J; Saxon, DH; Skillicorn, IO; Gialas, I; Carli, T; Gosau, T; Holm, U; Krumnack, N; Lohrmann, E; Milite, M; Salehi, H; Schleper, P; Schorner-Sadenius, T; Stonjek, S; Wichmann, K; Wick, K; Ziegler, A; Ziegler, A; Collins-Tooth, C; Foudas, C; Fry, C; Goncalo, R; Long, KR; Tapper, AD; Kataoka, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, AN; Boos, EG; Pokrovskiy, NS; Zhautykov, BO; Son, D; de Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jimenez, M; Labarga, L; del Peso, J; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Plamondon, M; Robichaud-Veronneau, A; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, BA; Rubinsky, I; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, RK; Ermolov, PF; Gladilin, LK; Katkov, II; Khein, LA; Korzhavina, IA; Kuzmin, VA; Levchenko, BB; Lukina, OY; Proskuryakov, AS; Shcheglova, LM; Zotkin, DS; Zotkin, SA; Abt, I; Buttner, C; Caldwell, A; Liu, X; Sutiak, J; Coppola, N; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Maddox, E; Tiecke, H; Vazquez, M; Wiggers, L; Brummer, N; Bylsma, B; Durkin, LS; Ling, TY; Allfrey, PD; Bell, MA; Sarkar, AMC; Cottrell, A; Devenish, RCE; Foster, B; Gwenlan, C; Kohno, T; Gorzo, KK; Patel, S; Straub, PB; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Ciesielski, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Heaphy, EA; Metlica, F; Oh, BY; Whitmore, JJ; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Hart, JC; Abramowicz, H; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Kuze, M; Kagawa, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Matsuzawa, K; Ota, O; Ri, YD; Costa, M; Ferrero, MI; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, JF; Butterworth, JM; Hall-Wilton, R; Jones, TW; Loizides, JH; Sutton, MR; Targett-Adams, C; Wing, M; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, RJ; Pawlak, JM; Sztuk, J; Tymieniecka, T; Tyszkiewicz, A; Ukleja, A; Ukleja, J; Zarnecki, AF; Adamus, M; Plucinski, P; Eisenberg, Y; Hochman, D; Karshon, U; Lightwood, MS; Brownson, E; Danielson, T; Everett, A; Kcira, D; Lammers, S; Li, L; Reeder, DD; Rosin, M; Ryan, P; Savin, AA; Smith, WH; Dhawan, S; Bhadra, S; Catterall, CD; Cui, Y; Hartner, G; Menary, S; Noor, U; Soares, M; Standage, J; Whyte, J Chekanov, S; Derrick, M; Magill, S; Miglioranzi, S; Musgrave, B; Repond, J; Yoshida, R; Mattingly, MCK; Pavel, N; Yagues, AG; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romeo, GC; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Margotti, A; Montanari, A; Nania, R; Palmonari, F; Pesci, A; Polini, A; Rinaldi, L; Sartorelli, G; Zichichi, A; Aghuzumtsyan, G; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Irrgang, P; Jakob, HP; Kind, OM; Meyer, U; Paul, E; Rautenberg, J; Renner, R; Voss, KC; Wang, M; Wlasenko, M; Bailey, DS; Brook, NH; Cole, JE; Heath, GP; Namsoo, T; Robins, S; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, JY; Ma, KJ; Helbich, M; Ning, Y; Ren, Z; Schmidke, WB; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Olkiewicz, K; Stopa, P; Szuba, D; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Kowal, AM; Lukasik, J; Przybycien, M; Suszycki, L; Szuba, J; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Borras, K; Drews, G; Fourletova, J; Geiser, A; Gladkov, D; Gottlicher, PG; Gutsche, O; Haas, T; Hain, W; Horn, C; Kahle, B; Kotz, U; Kowalski, H; Kramberger, G; Lelas, D; Lim, H; Lohr, B; Mankel, R; Melzer-Pellman, IA; Nguyen, CN; Notz, D; Nuncio-Quiroz, AE; Raval, A; Santamarta, R; Schneekloth, U; Stadie, H; Stosslein, U; Wolf, G; Youngman, C; Zeuner, W; Schlenstedt, S; Barbagli, G; Gallo, E; Genta, C; Pelfer, PG; Bamberger, A; Benen, A; Karstens, F; Dobur, D; Vlasov, NN; Bussey, PJ; Doyle, AT; Dunne, W; Ferrando, J; Hamilton, J; Saxon, DH; Skillicorn, IO; Gialas, I; Carli, T; Gosau, T; Holm, U; Krumnack, N; Lohrmann, E; Milite, M; Salehi, H; Schleper, P; Schorner-Sadenius, T; Stonjek, S; Wichmann, K; Wick, K; Ziegler, A; Ziegler, A; Collins-Tooth, C; Foudas, C; Fry, C; Goncalo, R; Long, KR; Tapper, AD; Kataoka, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, AN; Boos, EG; Pokrovskiy, NS; Zhautykov, BO; Son, D; de Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jimenez, M; Labarga, L; del Peso, J; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Plamondon, M; Robichaud-Veronneau, A; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, BA; Rubinsky, I; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, RK; Ermolov, PF; Gladilin, LK; Katkov, II; Khein, LA; Korzhavina, IA; Kuzmin, VA; Levchenko, BB; Lukina, OY; Proskuryakov, AS; Shcheglova, LM; Zotkin, DS; Zotkin, SA; Abt, I; Buttner, C; Caldwell, A; Liu, X; Sutiak, J; Coppola, N; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Maddox, E; Tiecke, H; Vazquez, M; Wiggers, L; Brummer, N; Bylsma, B; Durkin, LS; Ling, TY; Allfrey, PD; Bell, MA; Sarkar, AMC; Cottrell, A; Devenish, RCE; Foster, B; Gwenlan, C; Kohno, T; Gorzo, KK; Patel, S; Straub, PB; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Ciesielski, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Heaphy, EA; Metlica, F; Oh, BY; Whitmore, JJ; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Hart, JC; Abramowicz, H; Gabareen, A; Kananov, S; Kreisel, A; Levy, A; Kuze, M; Kagawa, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Matsuzawa, K; Ota, O; Ri, YD; Costa, M; Ferrero, MI; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, JF; Butterworth, JM; Hall-Wilton, R; Jones, TW; Loizides, JH; Sutton, MR; Targett-Adams, C; Wing, M; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, RJ; Pawlak, JM; Sztuk, J; Tymieniecka, T; Tyszkiewicz, A; Ukleja, A; Ukleja, J; Zarnecki, AF; Adamus, M; Plucinski, P; Eisenberg, Y; Hochman, D; Karshon, U; Lightwood, MS; Brownson, E; Danielson, T; Everett, A; Kcira, D; Lammers, S; Li, L; Reeder, DD; Rosin, M; Ryan, P; Savin, AA; Smith, WH; Dhawan, S; Bhadra, S; Catterall, CD; Cui, Y; Hartner, G; Menary, S; Noor, U; Soares, M; Standage, J; Whyte, J ZEUS Collaboration An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment EUROPEAN PHYSICAL JOURNAL C English Article DEEP-INELASTIC SCATTERING; PARTON DISTRIBUTIONS; PERTURBATION-THEORY; E(+)P SCATTERING; LEADING-ORDER; EP SCATTERING; HERA; ALPHA(S); PHOTOPRODUCTION; PHOTON The ZEUS inclusive differential cross-section data from HERA, for charged and neutral current processes taken with e(+) and e(-) beams, together with differential cross-section data on inclusive jet production in e+ p scattering and dijet production in gamma p scattering, have been used in a new NLO QCD analysis to extract the parton distribution functions of the proton. The input of jet-production data constrains the gluon and allows an accurate extraction of alpha(s)( M(Z)) at NLO; alpha(s)( M(Z)) = 0.1183 +/- 0.0028( exp.) +/- 0.0008( model). An additional uncertainty from the choice of scales is estimated as +/- 0.005. This is the first extraction of as( M(Z)) from HERA data alone. Argonne Natl Lab, Argonne, IL 60439 USA; Andrews Univ, Berrien Springs, MI 49104 USA; Humboldt Univ, Inst Phys, Berlin, Germany; Univ Bologna, Bologna, Italy; Ist Nazl Fis Nucl, I-40126 Bologna, Italy; Univ Bonn, Inst Phys, D-5300 Bonn, Germany; Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England; Univ Calabria, Dept Phys, I-87036 Cosenza, Italy; Ist Nazl Fis Nucl, I-87036 Cosenza, Italy; Chonnam Natl Univ, Kwangju 500757, South Korea; Columbia Univ, Nevis Labs, New York, NY 10027 USA; Inst Nucl Phys, Krakow, Poland; AGH Univ Sci & Technol, Fac Phys & Appl Com Sci, Krakow, Poland; Jagiellonian Univ, Dept Phys, Krakow, Poland; DESY, D-2000 Hamburg, Germany; DESY, Zeuthen, Germany; Univ Florence, Florence, Italy; Ist Nazl Fis Nucl, I-50125 Florence, Italy; Univ Freiburg, Fak Phys, D-7800 Freiburg, Germany; Univ Glasgow, Dept Phys & Astron, Glasgow, Lanark, Scotland; Univ Hamburg, Inst Phys Expt, Hamburg, Germany; Univ London Imperial Coll Sci Technol & Med, High Energy Nucl Phys Grp, London, England; Natl Lab High Energy Phys, KEK, Inst Particle & Nucl Studies, Tsukuba, Ibaraki 305, Japan; Minist Educ & Sci Kazakhstan, Inst Phys & Technol, Alma Ata, Kazakhstan; Kyungpook Natl Univ, Ctr High Energy Phys, Taegu 702701, South Korea; Univ Catholique Louvain, Inst Nucl Phys, B-1348 Louvain, Belgium; Univ Autonoma Madrid, Dept Fis Teor, Madrid, Spain; McGill Univ, Dept Phys, Montreal, PQ H3A 2T8, Canada; Meiji Gakuin Univ, Fac Gen Educ, Yokohama, Kanagawa, Japan; Moscow Engn Phys Inst, Moscow 115409, Russia; Moscow MV Lomonosov State Univ, Inst Nucl Phys, Moscow, Russia; Max Planck Inst Phys & Astrophys, D-80805 Munich, Germany; NIKHEF, Amsterdam, Netherlands; Univ Amsterdam, Amsterdam, Netherlands; Ohio State Univ, Dept Phys, Columbus, OH 43210 USA; Univ Oxford, Dept Phys, Oxford, England; Univ Padua, Dept Fis, Padua, Italy; Ist Nazl Fis Nucl, Padua, Italy; Penn State Univ, Dept Phys, University Pk, PA 16802 USA; Polytech Univ, Sagamihara, Kanagawa, Japan; Univ Roma La Sapienza, Dipartimento Fis, Rome, Italy; Ist Nazl Fis Nucl, Rome, Italy; Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Phys, IL-69978 Tel Aviv, Israel; Tokyo Inst Technol, Dept Phys, Tokyo 152, Japan; Univ Tokyo, Dept Phys, Tokyo 113, Japan; Tokyo Metropolitan Univ, Dept Phys, Tokyo 158, Japan; Univ Turin, Turin, Italy; Ist Nazl Fis Nucl, I-10125 Turin, Italy; Univ Piemonte Orientale, Novara, Italy; Ist Nazl Fis Nucl, I-10125 Turin, Italy; Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; UCL, Dept Phys & Astron, London, England; Warsaw Univ, Inst Expt Phys, Warsaw, Poland; Inst Nucl Studies, PL-00681 Warsaw, Poland; Weizmann Inst Sci, Dept Particle Phys, IL-76100 Rehovot, Israel; Univ Wisconsin, Dept Phys, Madison, WI 53706 USA; Yale Univ, Dept Phys, New Haven, CT 06520 USA; York Univ, Dept Phys, N York, ON M3J 1P3, Canada; UCL, London, England; Max Planck Inst, Munich, Germany Chekanov, S (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. De Pasquale, Salvatore/B-9165-2008; Wing, Matthew/C-2169-2008; Fazio, Salvatore /G-5156-2010; Doyle, Anthony/C-5889-2009; collins-tooth, christopher/A-9201-2012; Ferrando, James/A-9192-2012; Gladilin, Leonid/B-5226-2011; Levchenko, B./D-9752-2012; Proskuryakov, Alexander/J-6166-2012; Dementiev, Roman/K-7201-2012 Ferrando, James/0000-0002-1007-7816; Gladilin, Leonid/0000-0001-9422-8636; 49 102 102 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1434-6044 EUR PHYS J C Eur. Phys. J. C JUL 2005 42 1 1 16 10.1140/epjc/s2005-02293-x 16 Physics, Particles & Fields Physics 953ZK WOS:000231123700001 J Limatola, C; Di Bartolomeo, S; Catalano, M; Trettel, F; Fucile, S; Castellani, L; Eusebi, F Limatola, C; Di Bartolomeo, S; Catalano, M; Trettel, F; Fucile, S; Castellani, L; Eusebi, F Cysteine residues are critical for chemokine receptor CXCR2 functional properties EXPERIMENTAL CELL RESEARCH English Article CXCR2; cysteines; chemotaxis; signal transduction; receptor dimerization PROTEIN-COUPLED RECEPTORS; CELL-SURFACE EXPRESSION; SIGNAL-TRANSDUCTION; LIGAND-BINDING; HEK CELLS; DIMERIZATION; NEURONS; INTERNALIZATION; INTERLEUKIN-8; ROLES We examined the role of cysteine (Cys) residues present in chemokine receptor CXCR2 for proper surface expression, dimerization, signaling, and chemotaxis. To address this issue, serine or leucine residues were substituted for Cys, generating nine CXCR2 mutants transiently expressed in HEK cells. Single substitution of Cys residues present in the three extracellular loops (C119L, C196L, C286S) or in the seventh-transmembrane (TM) domain (C308L) abolished CXCL8 agonist binding, while no Cys substitution abolished surface receptor expression. We have previously demonstrated that CXCR2 dimerizes under reducing conditions, due to hydrophobic interactions that involve TM3 regions, and here we show that the dimer/monomer CXCR2 ratio drastically increases when analyzed under non-reducing conditions. We report that none of the Cys-deficient CXCR2 mutants abolishes receptor dimerization, demonstrating that Cys-Cys bonds are not the exclusive determinant of CXCR2 dimerization. Furthermore, both wt- and Cys-mutated CXCR2 dimers are expressed at the cell surface, indicating that receptor dimers are efficiently transferred at the plasma membrane. We also show that every Cys substitution in CXCR2, including those that still bind CXCL8, results in an impairment of receptor activity, analyzed as cell chemotaxis and intracellular signaling, suggesting that some structural requirement is likely fulfilled by Cys presence. (c) 2005 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Ist Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, Ctr Eccellenza BEMM, I-00185 Rome, Italy; Neuromed IRCCS, I-186077 Isernia, Italy; Univ Cassino, Dipartimento Sci Mororie & Salute, I-03043 Cassino, Italy; Fdn Santa Lucia, I-00179 Rome, Italy Limatola, C (reprint author), Citta Univ, Ist Fisiol Umana, Piazzale Aldo Moro 5, I-00185 Rome, Italy. cristina.limatola@uniroma1.it Fucile, Sergio/B-3934-2010 Fucile, Sergio/0000-0003-0698-1148 32 8 8 ELSEVIER INC SAN DIEGO 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495, UNITED STATES 0014-4827 EXP CELL RES Exp. Cell Res. JUL 1 2005 307 1 65 75 10.1016/j.yexer.2005.02.020 11 Oncology; Cell Biology Oncology; Cell Biology 934QJ WOS:000229723000006 J Kricka, LJ; Park, JY; Li, SFY; Fortina, P Kricka, LJ; Park, JY; Li, SFY; Fortina, P Miniaturized detection technology in molecular diagnostics EXPERT REVIEW OF MOLECULAR DIAGNOSTICS English Review carbon nanotube; electrochemical detection; microchip CE; multiplexing; nanoparticles; nanopore; nanotechnology; non-PCR testing POLYMERASE-CHAIN-REACTION; GOLD NANOPARTICLE PROBES; SOLID-STATE NANOPORE; HEPATITIS-C VIRUS; MICROCHIP ELECTROPHORESIS; DNA HYBRIDIZATION; CAPILLARY-ELECTROPHORESIS; GENOMIC DNA; ELECTROCHEMICAL DETECTION; HETERODUPLEX ANALYSIS Miniaturization of genetic tests represents the convergence of molecular biology and engineering and is leading to a new class of small analyzers and test systems for genetic testing with improved analytical characteristics. Miniaturization initially focused on devices that contained micrometer-sized features designed for a particular analytical purpose (e.g., filters for cell isolation and chips for capillary electrophoresis). Now, the focus is shifting to analytical applications based on nano-sized objects such as nanotubes, nanochannels, nanoparticles, nanopores and nanocapacitors. These nanofabricated objects provide new tools for sequencing of nucleic acids and rapid, multiplexed, nucleic acid detection. Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore; Thomas Jefferson Univ, Ctr Translat Med, Philadelphia, PA 19107 USA; Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy Kricka, LJ (reprint author), Univ Penn, Sch Med, Dept Pathol & Lab Med, 7-103 Founders Pavilion,3400 Spruce St, Philadelphia, PA 19104 USA. kricka@mail.med.upenn.edu; jason_park@uphs.upenn.edu; chmlifys@nus.edu.sg; paolo.forting@jefferson.edu Li, Sam/J-3113-2013 Li, Sam/0000-0002-2092-9226 94 15 16 FUTURE DRUGS LTD LONDON UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEYY CENTRAL, LONDON N3 1QB, ENGLAND 1473-7159 EXPERT REV MOL DIAGN Expert Rev. Mol. Diagn. JUL 2005 5 4 549 559 10.1586/14737159.5.4.549 11 Pathology Pathology 943WH WOS:000230385100010 J Gharbiya, M; Grandinetti, F; Gabrieli, CB Gharbiya, M; Grandinetti, F; Gabrieli, CB Intravitreal triamcinolone for macular detachment following panretinal photocoagulation EYE English Letter EDEMA; ACETONIDE Univ Roma La Sapienza, Dept Ophthalmol, I-00161 Rome, Italy Gharbiya, M (reprint author), Univ Roma La Sapienza, Dept Ophthalmol, Vle Policlin 155, I-00161 Rome, Italy. magda.gharbiya@tiscali.it 6 4 4 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0950-222X EYE Eye JUL 2005 19 7 818 820 10.1038/sj.eye.6701658 4 Ophthalmology Ophthalmology 942TA WOS:000230304100028 J Centorrino, F; Fogarty, KV; Sani, G; Salvatore, P; Cimbolli, P; Baldessarini, RJ Centorrino, F; Fogarty, KV; Sani, G; Salvatore, P; Cimbolli, P; Baldessarini, RJ Antipsychotic drug use: McLean Hospital, 2002 HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL English Article antipsychotic; inpatient; polypharmacy; olanzapine; antipsychotic dosing; prescribing pattern Objective Major changes in antipsychotic treatment in recent years encouraged a survey of inpatient practice in 2002, compared with earlier samples. Methods Based on records of a random sample of McLean Hospital inpatients prescribed antipsychotics in 2002, the study recorded DSM-IV discharge diagnosis, all psychotropic treatments and doses, initial, peak and final doses of all antipsychotics, clinical status at admission and discharge, and adverse effects reported. Results were compared with similar data from our earlier surveys. Results Subjects were 344 inpatients (n = 202 women, 59%), diagnosed with psychotic (n = 102, 30%), bipolar (n = 93, 27%), major depressive (n = 67, 19.5%), dementia (n = 19, 5.5%), substance-use (n = 28, 8%) or other psychiatric disorders (n = 35, 10%). Second-generation antipsychotics accounted for 88% of antipsychotic prescriptions; 17% of patients received >= 2 antipsychotics and total CPZ-eq discharge does in 2002 averaged 291 +/- 305 mg/day (22% less than a 1998 peak). Doses were unrelated to age, but higher in men, among psychotic vs major affective disorder patients, and with greater illness-severity and longer hospitalization. There was a 3.3-fold increase in the simultaneous use of >= 3 psychotropic agents since 1998. Conclusions The use of second-generation antipsychotics dominates current inpatient practice. Total antipsychotic dosing has not increased recently, but the use of multiple psychotropics increased strikingly from 1998 to 2002. Copyright (C) 2005 John Wiley & Sons, Ltd. McLean Hosp, Schizophrenia & Bipolar Disorder Clin, Schizophrenia & Bipolar Disorder Program, Belmont, MA 02478 USA; Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA; Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA; McLean Hosp, Psychopharmacol Program, Belmont, MA 02478 USA Centorrino, F (reprint author), McLean Hosp, Schizophrenia & Bipolar Disorder Clin, Schizophrenia & Bipolar Disorder Program, N Belknap 3,115 Mill St, Belmont, MA 02478 USA. centorf@mcleanpo.mclean.org 7 12 12 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0885-6222 HUM PSYCHOPHARM CLIN Hum. Psychopharmacol.-Clin. Exp. JUL 2005 20 5 355 358 10.1002/hup.700 4 Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology 951ZG WOS:000230970300006 J Bianco, L; Cimini, D; Marzano, FS; Ware, R Bianco, L; Cimini, D; Marzano, FS; Ware, R Combining microwave radiometer and wind profiler radar measurements for high-resolution atmospheric humidity profiling JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY English Article CLOUD LIQUID; WATER-VAPOR; BOUNDARY-LAYER; TEMPERATURE; GRADIENTS; CONTAMINATION; TURBULENCE; RETRIEVAL; SYSTEM A self-consistent remote sensing physical method to retrieve atmospheric humidity high-resolution profiles by synergetic use of a microwave radiometer profiler (N/lWRP) and wind profiler radar (WPR) is illustrated. The proposed technique is based on the processing of WPR data for estimating the potential refractivity gradient profiles and their optimal combination with MWRP estimates of potential temperature profiles in order to fully retrieve humidity gradient profiles. The combined algorithm makes use of recent developments in WPR signal processing, computing the zeroth-, first-, and second-order moments of WPR Doppler spectra via a fuzzy logic method, which provides quality control of radar data in the spectral domain. On the other hand, the application of neural network to brightness temperatures, measured by a multichannel MWRP, can provide continuous estimates of tropospheric temperature and humidity profiles. Performance of the combined algorithm in retrieving humidity profiles is compared with simultaneous in situ radiosonde observations (raob's). The empirical sets of WPR and MWRP data were collected at the Atmospheric Radiation Measurement (ARM) Program's Southern Great Plains (SGP) site. Combined microwave radiometer and wind profiler measurements show encouraging results and significantly improve the spatial vertical resolution of atmospheric humidity profiles. Finally, some of the limitations found in the use of this technique and possible future improvements are also discussed. Univ Aquila, Dipartimento Fis & Atmosfera, CETEMPS, Ctr Excellence, I-67010 Coppito, Italy; Univ Colorado, NOAA, Environm Technol Lab, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA Bianco, L (reprint author), Univ Aquila, Dipartimento Fis & Atmosfera, CETEMPS, Ctr Excellence, Via Vetoio, I-67010 Coppito, Italy. Laura.Bianco@aquila.infn.it 33 11 11 AMER METEOROLOGICAL SOC BOSTON 45 BEACON ST, BOSTON, MA 02108-3693 USA 0739-0572 J ATMOS OCEAN TECH J. Atmos. Ocean. Technol. JUL 2005 22 7 949 965 10.1175/JTECH1771.1 17 Engineering, Ocean; Meteorology & Atmospheric Sciences Engineering; Meteorology & Atmospheric Sciences 960MA WOS:000231595500012 J Grimaldi, L; De Giorgio, F; Masullo, M; Zoccai, GB; Martinotti, G; Rainio, J Grimaldi, L; De Giorgio, F; Masullo, M; Zoccai, GB; Martinotti, G; Rainio, J Suicide by pencil JOURNAL OF FORENSIC SCIENCES English Article forensic science; suicide; chest wound; pencil wound; cardiac injury FEATURES We report an unusual suicide, committed with a common pencil. A 72-year-old male inflicted himself a penetrating thoracic wound while being hospitalized for a hip prosthesis operation. Although the patient was immediately operated, the cardiac injury appeared to be fatal. Cases of suicidal penetrating wounds of the anterior chest wall are rare and they are mostly inflicted by knives, glass fragments, or other sharp instruments. The potential danger of a pencil should be taken into consideration, especially in psychiatric hospitals and imprisonment facilities. We examined the legislation in Italy and Finland concerning the regulation of privacy in special care institutions. Univ Sacred Heart, Sch Med, Inst Legal Med, I-00168 Rome, Italy; Univ Sacred Heart, Inst Cardiol, I-00168 Rome, Italy; Univ Sacred Heart, Inst Psychiat, I-00168 Rome, Italy De Giorgio, F (reprint author), Univ Sacred Heart, Sch Med, Inst Legal Med, Largo F Vito,1, I-00168 Rome, Italy. fdegiorgio@tiscalinet.it 6 1 1 AMER SOC TESTING MATERIALS W CONSHOHOCKEN 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA 0022-1198 J FORENSIC SCI J. Forensic Sci. JUL 2005 50 4 913 914 2 Medicine, Legal Legal Medicine 939GY WOS:000230061800025 J Tari, Z; Broberg, J; Zomaya, AY; Baldoni, R Tari, Z; Broberg, J; Zomaya, AY; Baldoni, R A least flow-time first load sharing approach for distributed server farm JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING English Article scheduling policies; task assignment; heavy-tailed workloads; load balancing; load sharing SYSTEMS The most critical property exhibited by a heavy-tailed workload distribution (found in many WWW workloads) is that a very small fraction of tasks make up a large fraction of the workload, making the load very difficult to distribute in a distributed system. Load balancing and load sharing are the two predominant load distribution strategies used in such systems. Load sharing generally has better response time than load balancing because the latter can exhibit excessive overheads in selecting servers and partitioning tasks. We therefore further explored the least-loaded-first (LLF) load sharing approach and found two important limitations: (a) LLF does not consider the order of processing, and (b) when it assigns a task, LLF does not consider the processing capacity of servers. The high task size variation that exists in heavy-tailed workloads often causes smaller tasks to be severely delayed by large tasks. This paper proposes a size-based approach, called the least flow-time first (LFF-SIZE), which reduces the delay caused by size variation while maintaining a balanced load in the system. LFF-SIZE takes the relative processing time of a task into account and dynamically assigns a task to the fittest server with a lighter load and higher processing capacity. LFF-SIZE also uses a multi-section queue to separate larger tasks from smaller ones. This arrangement effectively reduces the delay of smaller tasks by larger ones as small tasks are given a higher priority to be processed. The performance results performed on the LFF-SIZE implementation shows a substantial improvement over existing load sharing and static size-based approaches under realistic heavy-tailed workloads. (c) 2005 Elsevier Inc. All rights reserved. RMIT Univ, Melbourne, Vic, Australia; Univ Sydney, Sydney, NSW 2006, Australia; Univ Rome, Rome, Italy Zomaya, AY (reprint author), RMIT Univ, Melbourne, Vic, Australia. zomaya@it.usyd.edu.au 17 8 8 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0743-7315 J PARALLEL DISTR COM J. Parallel Distrib. Comput. JUL 2005 65 7 832 842 10.1016/j.jpdc.2005.02.007 11 Computer Science, Theory & Methods Computer Science 935CH WOS:000229756300004 J Franceschini, G; Geffert, V Franceschini, G; Geffert, V An in-place sorting with O (n log n) comparisons and O(n) moves JOURNAL OF THE ACM English Article algorithms; sorting in-place MINIMUM DATA MOVEMENT; HEAPSORT We present the first in-place algorithm for sorting an array of size n that performs, in the worst case, at most 0 (n log n) element comparisons and 0 (n) element transports. This solves a long-standing open problem, stated explicitly, for example, in Munro and Raman 1992], of whether there exists a sorting algorithm that matches the asymptotic lower bounds on all computational resources simultaneously. Univ Pisa, Dept Informat, I-56127 Pisa, Italy; Safarik Univ, Kosice, Slovakia Franceschini, G (reprint author), Univ Pisa, Dept Informat, Largo B Pontecorvo 3, I-56127 Pisa, Italy. francesc@di.unipi.it; geffert@upjs.sk 19 6 7 ASSOC COMPUTING MACHINERY NEW YORK 1515 BROADWAY, NEW YORK, NY 10036 USA 0004-5411 J ACM J. ACM JUL 2005 52 4 515 537 10.1145/1082036.1082037 23 Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods Computer Science 966KV WOS:000232019500001 J Aloisio, A; Ambrosino, F; Antonelli, A; Antonelli, M; Bacci, C; Barva, M; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocci, V; Bossi, F; Branchini, P; Bulychjov, SA; Caloi, R; Campana, P; Capon, G; Capussela, T; Carboni, G; Ceradini, F; Cervelli, F; Cevenini, F; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Erriquez, O; Farilla, A; Felici, G; Ferrari, A; Ferrer, ML; Finocchiaro, G; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Lu, F; Martemianov, M; Martini, M; Matsyuk, M; Mei, W; Merola, L; Messi, R; Miscetti, S; Moulson, M; Muller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passalacqua, L; Passeri, A; Patera, V; Perfetto, F; Petrolo, E; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Schamberger, RD; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A; Spadaro, T; Spiriti, E; Tabidze, M; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, S; Ventura, A; Versaci, R; Villella, I; Xu, G; Leone, D Aloisio, A; Ambrosino, F; Antonelli, A; Antonelli, M; Bacci, C; Barva, M; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocci, V; Bossi, F; Branchini, P; Bulychjov, SA; Caloi, R; Campana, P; Capon, G; Capussela, T; Carboni, G; Ceradini, F; Cervelli, F; Cevenini, F; Chiefari, G; Ciambrone, P; Conetti, S; De Lucia, E; De Santis, A; De Simone, P; De Zorzi, G; Dell'Agnello, S; Denig, A; Di Domenico, A; Di Donato, C; Di Falco, S; Di Micco, B; Doria, A; Dreucci, M; Erriquez, O; Farilla, A; Felici, G; Ferrari, A; Ferrer, ML; Finocchiaro, G; Forti, C; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Gorini, E; Graziani, E; Incagli, M; Kluge, W; Kulikov, V; Lacava, F; Lanfranchi, G; Lee-Franzini, J; Leone, D; Lu, F; Martemianov, M; Martini, M; Matsyuk, M; Mei, W; Merola, L; Messi, R; Miscetti, S; Moulson, M; Muller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passalacqua, L; Passeri, A; Patera, V; Perfetto, F; Petrolo, E; Pontecorvo, L; Primavera, M; Santangelo, P; Santovetti, E; Saracino, G; Schamberger, RD; Sciascia, B; Sciubba, A; Scuri, F; Sfiligoi, I; Sibidanov, A; Spadaro, T; Spiriti, E; Tabidze, M; Testa, M; Tortora, L; Valente, P; Valeriani, B; Venanzoni, G; Veneziano, S; Ventura, A; Versaci, R; Villella, I; Xu, G; Leone, D The hadronic cross section measurement at KLOE NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper 8th International Workshop on Tau Lepton Physics SEP 14-17, 2004 Nara, JAPAN TO-LEADING ORDER; RADIATIVE RETURN; E(+)E(-) ANNIHILATION; MAGNETIC-MOMENT; TAGGED PHOTONS; MUON; FACTORIES; CMD-2; NLO KLOE uses the radiative return to measure cross section sigma(e(+) e(-) -> pi(+) pi(-) gamma) at the electron-positron collider DA Phi NE. Divinding by a theoretical radiator function, we obtain the cross section sigma(e(+) e(-) -> pi(+) pi(-)) for the mass range 0.35 < s(pi) < 0.95 GeV2. We calculate the hadronic contribution to the muon anomaly for the given mass range: a(mu) = 388.7 +/- 0.8(stat) +/- 3.5syst +/- 3.5(th). Univ Karlsruhe, Inst Expt Kernphys, D-76021 Karlsruhe, Germany; Univ Lecce Sezione, INFN, Lecce, Italy Aloisio, A (reprint author), Univ Karlsruhe, Inst Expt Kernphys, Postfach 3640, D-76021 Karlsruhe, Germany. valente, paolo/A-6640-2010; Di Domenico, Antonio/G-6301-2011; De Lucia, Erika/D-2250-2011; branchini, paolo/A-4857-2011; Murtas, Fabrizio/B-5729-2012; De Santis, Antonio/J-1453-2012; Veneziano, Stefano/J-1610-2012; Di Micco, Biagio/J-1755-2012; de Simone, Patrizia/J-3549-2012; Gauzzi, Paolo/D-2615-2009 valente, paolo/0000-0002-5413-0068; De Lucia, Erika/0000-0003-0793-0844; De Santis, Antonio/0000-0002-8613-8128; Veneziano, Stefano/0000-0002-2598-2659; 18 3 3 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. JUL 2005 144 231 237 10.1016/j.nuclphysbps.2005.02.032 7 Physics, Particles & Fields Physics 925LQ WOS:000229055000033 J Ruffini, R; Bernardini, MG; Bianco, CL; Chardonnet, P; Fraschetti, F; Gurzadyan, V; Lattanzi, M; Vitagliano, L; Xue, SS Ruffini, R; Bernardini, MG; Bianco, CL; Chardonnet, P; Fraschetti, F; Gurzadyan, V; Lattanzi, M; Vitagliano, L; Xue, SS Extracting energy from black holes: "Long" and "short" GRBs and their astrophysical settings NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA C-GEOPHYSICS AND SPACE PHYSICS English Article; Proceedings Paper 4th Workshop on Gamma-Ray Bursts in the Afterglow Era OCT 18-22, 2004 Rome, ITALY GAMMA-RAY BURSTS; NEUTRON-STARS; GRAVITATIONAL COLLAPSE; LOW-LUMINOSITY; TRANSFORMATIONS; EQUILIBRIUM; ATMOSPHERES; SPECTRA; PHYSICS; PLASMA The introduction of the three interpretational paradigms for Gamma-Ray Bursts (GRBs) and recent progress in understanding the X- and gamma-ray luminosity in the afterglow allow us to make assessments about the astrophysical settings of GRBs. In particular, we evidence the distinct possibility that some GRBs occur in a, binary system. This subclass of GRBs manifests itself in a tryptich": one component formed by the collapse of a massive star to a black hole. which originates the GRB; a second component by a supernova and a third one by a young neutron star born in the supernova event. Similarly. the understanding of the physics of quantum relativistic processes during the gravitational collapse makes possible precise predictions about the structure of short GRBs.

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			01 Pubblicazione su rivista::01a Articolo in rivista
		
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			Interobserver reliability of rheumatologists performing musculoskeletal ultrasonography: results from a EULAR ''Train the trainers'' course / A. K., Scheel; W. A., Schmidt; K. G. A., Hermann; G. A., Bruyn; M. A., D'Agostino; W., Grassi; Iagnocco, Annamaria; J. M., Koski; K. P., Machold; E., Naredo; H., Sattler; N., Swen; M., Szkudlarek; R. J., Wakefield; H. R., Ziswiler; D., Pasewaldt; C., Werner; M., Backhaus. - In: IL NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. C, GEOPHYSICS AND SPACE PHYSICS. - ISSN 1124-1896. - STAMPA. - 28:7(2005), pp. 589-596. [10.1136/ard.2004.030387]
		
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/118813

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