The new era of IVF and social freezing could change our ethical indication of the monitoring and treatment of brain lesions, especially those related to hormones such as meningiomas. The data regarding IVF in Italy (IARTR Italian Assisted Reproductive Technology Register) reveal a progressive increase of cycles from 52676 cycles in 2010 to 95110 in 2013. The same results have been reported in Europe (European Register EHSRE 2013) (1) and the results of the data from the last 4 years confirm this trend. This indicates that the “incidental hormone related lesions” will strongly increase over the coming years. Meningiomas represent the most common primary brain tumor (34% of CNS). Incidence in females is nearly twice of that in men (2). Recent data reported incidental meningioma findings in 2.5% of the population. Ten percent of meningiomas contain estrogen receptors. A large number of meningiomas show very slow growth (3). The literature reports several cases regarding meningiomas fast growing in hyperestrogenic and hyperprogestinic states. In recent studies, progesterone also seems to be strongly correlated to increased risks of recurrence compared to estrogen and estrogen/progesterone . Estrogen expression in meningiomas is present in a much higher proportion of cases than expression based on immunohistochemical results due to the different sensitivity of the applied technique. While the functional role of the estrogen expression is still debated the majority of meningiomas express progesterone (PR) receptors (4)

In vitro fertilization (IVF) and hormone-dependent brain tumors: could the new era of IVF and social freezing change our incidentally discovered brain tumor management? / Cardia, Andrea; Zerbetto, Irene; Cannizzaro, Delia; Picozzi, Piero; Fornari, Maurizio; Levi Setti, Paolo; Servadei, Franco. - In: JOURNAL OF NEUROSURGICAL SCIENCES. - ISSN 0390-5616. - (2018). [10.23736/S0390-5616.18.04469-7]

In vitro fertilization (IVF) and hormone-dependent brain tumors: could the new era of IVF and social freezing change our incidentally discovered brain tumor management?

Cannizzaro, Delia;
2018

Abstract

The new era of IVF and social freezing could change our ethical indication of the monitoring and treatment of brain lesions, especially those related to hormones such as meningiomas. The data regarding IVF in Italy (IARTR Italian Assisted Reproductive Technology Register) reveal a progressive increase of cycles from 52676 cycles in 2010 to 95110 in 2013. The same results have been reported in Europe (European Register EHSRE 2013) (1) and the results of the data from the last 4 years confirm this trend. This indicates that the “incidental hormone related lesions” will strongly increase over the coming years. Meningiomas represent the most common primary brain tumor (34% of CNS). Incidence in females is nearly twice of that in men (2). Recent data reported incidental meningioma findings in 2.5% of the population. Ten percent of meningiomas contain estrogen receptors. A large number of meningiomas show very slow growth (3). The literature reports several cases regarding meningiomas fast growing in hyperestrogenic and hyperprogestinic states. In recent studies, progesterone also seems to be strongly correlated to increased risks of recurrence compared to estrogen and estrogen/progesterone . Estrogen expression in meningiomas is present in a much higher proportion of cases than expression based on immunohistochemical results due to the different sensitivity of the applied technique. While the functional role of the estrogen expression is still debated the majority of meningiomas express progesterone (PR) receptors (4)
2018
brain tumor management, cerebral meningioma
01 Pubblicazione su rivista::01a Articolo in rivista
In vitro fertilization (IVF) and hormone-dependent brain tumors: could the new era of IVF and social freezing change our incidentally discovered brain tumor management? / Cardia, Andrea; Zerbetto, Irene; Cannizzaro, Delia; Picozzi, Piero; Fornari, Maurizio; Levi Setti, Paolo; Servadei, Franco. - In: JOURNAL OF NEUROSURGICAL SCIENCES. - ISSN 0390-5616. - (2018). [10.23736/S0390-5616.18.04469-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1187232
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