Growing evidence supports the pivotal role played by oxidative stress in tissue injury development, thus resulting in several pathologies including cardiovascular, renal, neuropsychiatric, and neurodegenerative disorders, all characterized by an altered oxidative status. Reactive oxygen and nitrogen species and lipid peroxidation-derived reactive aldehydes including acrolein, malondialdehyde, and 4-hydroxy-2-nonenal, among others, are the main responsible for cellular and tissue damages occurring in redox-dependent processes. In this scenario, a link between the endocannabinoid system (ECS) and redox homeostasis impairment appears to be crucial. Anandamide and 2-arachidonoylglycerol, the best characterized endocannabinoids, are able to modulate the activity of several antioxidant enzymes through targeting the cannabinoid receptors type 1 and 2 as well as additional receptors such as the transient receptor potential vanilloid 1, the peroxisome proliferator-activated receptor alpha, and the orphan G protein-coupled receptors 18 and 55. Moreover, the endocannabinoids lipid analogues N-acylethanolamines showed to protect cell damage and death from reactive aldehydes-induced oxidative stress by restoring the intracellular oxidants-antioxidants balance. In this review, we will provide a better understanding of the main mechanisms triggered by the cross-talk between the oxidative stress and the ECS, focusing also on the enzymatic and non-enzymatic antioxidants as scavengers of reactive aldehydes and their toxic bioactive adducts.

Modulation of the oxidative stress and lipid peroxidation by endocannabinoids and their lipid analogues / Gallelli, Cristina Anna; Calcagnini, Silvio; Romano, Adele; Koczwara, Justyna Barbara; de Ceglia, Marialuisa; Dante, Donatella; Villani, Rosanna; Giudetti, Anna Maria; Cassano, Tommaso; Gaetani, Silvana. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 7:7(2018). [10.3390/antiox7070093]

Modulation of the oxidative stress and lipid peroxidation by endocannabinoids and their lipid analogues

Gallelli, Cristina Anna
Co-primo
;
Calcagnini, Silvio
Co-primo
;
Romano, Adele
Secondo
;
Koczwara, Justyna Barbara;de Ceglia, Marialuisa;Dante, Donatella;Gaetani, Silvana
Ultimo
2018

Abstract

Growing evidence supports the pivotal role played by oxidative stress in tissue injury development, thus resulting in several pathologies including cardiovascular, renal, neuropsychiatric, and neurodegenerative disorders, all characterized by an altered oxidative status. Reactive oxygen and nitrogen species and lipid peroxidation-derived reactive aldehydes including acrolein, malondialdehyde, and 4-hydroxy-2-nonenal, among others, are the main responsible for cellular and tissue damages occurring in redox-dependent processes. In this scenario, a link between the endocannabinoid system (ECS) and redox homeostasis impairment appears to be crucial. Anandamide and 2-arachidonoylglycerol, the best characterized endocannabinoids, are able to modulate the activity of several antioxidant enzymes through targeting the cannabinoid receptors type 1 and 2 as well as additional receptors such as the transient receptor potential vanilloid 1, the peroxisome proliferator-activated receptor alpha, and the orphan G protein-coupled receptors 18 and 55. Moreover, the endocannabinoids lipid analogues N-acylethanolamines showed to protect cell damage and death from reactive aldehydes-induced oxidative stress by restoring the intracellular oxidants-antioxidants balance. In this review, we will provide a better understanding of the main mechanisms triggered by the cross-talk between the oxidative stress and the ECS, focusing also on the enzymatic and non-enzymatic antioxidants as scavengers of reactive aldehydes and their toxic bioactive adducts.
2018
cannabinoid receptors; endocannabinoids; free radicals; G protein-coupled receptors; lipid peroxidation; oxidative stress; peroxisome proliferator-activated receptors; reactive aldehydes; reactive oxygen and nitrogen species; transient receptor potential vanilloid; physiology; biochemistry; molecular biology; clinical biochemistry; cell biology
01 Pubblicazione su rivista::01a Articolo in rivista
Modulation of the oxidative stress and lipid peroxidation by endocannabinoids and their lipid analogues / Gallelli, Cristina Anna; Calcagnini, Silvio; Romano, Adele; Koczwara, Justyna Barbara; de Ceglia, Marialuisa; Dante, Donatella; Villani, Rosanna; Giudetti, Anna Maria; Cassano, Tommaso; Gaetani, Silvana. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 7:7(2018). [10.3390/antiox7070093]
File allegati a questo prodotto
File Dimensione Formato  
Gallelli_Modulation_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.68 MB
Formato Adobe PDF
2.68 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1186952
Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 74
  • ???jsp.display-item.citation.isi??? 70
social impact