Abstract Objective: The objective of this double-blind, placebo-controlled urodynamic pressure/flow study was to assess the efficacy of short-term treatment with the α 1-blocker alfuzosin in outflow obstruction of patients with symptomatic benign prostatic hyperplasia (BPH). Material and Methods: Urodynamic pressure/flow parameters were assessed after 2 weeks of placebo run-in, 4 weeks of placebo (47 patients) or 2.5 mg t.i.d. alfuzosin treatment (47 patients), followed by an 8-week extension period with alfuzosin (single-blind). Results and Conclusion: Four weeks of alfuzosin treatment significantly increased maximum flow (+29.0%) and decreased detrusor pressure at maximum flow (-30.2%), detrusor opening pressure (-39.4%) and maximum detrusor pressure (-28.7%). Short-term alfuzosin treatment improved outflow conditions in BPH by reducing prostatic urethral obstruction

Effects of short-term treatment with the alpha(1)-blocker alfuzosin on urodynamic pressure flow parameters in patients with benign prostatic hyperplasia / G., Martorana; C., Giberti; DI SILVERIO, Franco; VON HELAND, Magnus; P., Rigatti; R., Colombo; G., Casadei; P., Pacifico. - In: EUROPEAN UROLOGY. - ISSN 0302-2838. - STAMPA. - 32:1(1997), pp. 47-53.

Effects of short-term treatment with the alpha(1)-blocker alfuzosin on urodynamic pressure flow parameters in patients with benign prostatic hyperplasia

DI SILVERIO, Franco;VON HELAND, Magnus;
1997

Abstract

Abstract Objective: The objective of this double-blind, placebo-controlled urodynamic pressure/flow study was to assess the efficacy of short-term treatment with the α 1-blocker alfuzosin in outflow obstruction of patients with symptomatic benign prostatic hyperplasia (BPH). Material and Methods: Urodynamic pressure/flow parameters were assessed after 2 weeks of placebo run-in, 4 weeks of placebo (47 patients) or 2.5 mg t.i.d. alfuzosin treatment (47 patients), followed by an 8-week extension period with alfuzosin (single-blind). Results and Conclusion: Four weeks of alfuzosin treatment significantly increased maximum flow (+29.0%) and decreased detrusor pressure at maximum flow (-30.2%), detrusor opening pressure (-39.4%) and maximum detrusor pressure (-28.7%). Short-term alfuzosin treatment improved outflow conditions in BPH by reducing prostatic urethral obstruction
1997
alfuzosin; benign prostatic hyperplasia; urodynamics; α 1-antagonist
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of short-term treatment with the alpha(1)-blocker alfuzosin on urodynamic pressure flow parameters in patients with benign prostatic hyperplasia / G., Martorana; C., Giberti; DI SILVERIO, Franco; VON HELAND, Magnus; P., Rigatti; R., Colombo; G., Casadei; P., Pacifico. - In: EUROPEAN UROLOGY. - ISSN 0302-2838. - STAMPA. - 32:1(1997), pp. 47-53.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/118623
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