Radical Cystectomy for Stage T1g3 Transitional Cell Carcinoma of the Bladder: Long-term Follow-up

Abstract Between January 1979 and January 1989, 36 patients underwent bilateral pelvic lymph node dissection and radical cystectomy with urinary diversion for the management of stage T1 Transitional Cell Carcinoma: 22 (61.1%) had stage T1 and 14 (38.8%) T1CISG3. Follow-up ranged from 15 to 180 months, median 120 months. Sex, age, focality and associated CIS were considered in a multivariate analysis to identify characteristics likely to be of significance to predict the outcome of stage T1 tumours. Fifteen patients (41.6%) remained free of disease whilst 11 (30.6%) had positive pelvic lymph nodes. The overall mean survival time was 8.9 years and the overall 10-year cancer specific mortality was 61.1% (22 patients): in 11 patients (30.5%), death was due to cancer. The multivariate analysis showed that lymph node involvement and associated CIS implied a significantly worse prognosis of stage T1 tumours as far as concerns evolution of the disease. Results suggest that early radical treatment is effective in patients with 'aggressive' (i.e., lymph node involvement, associated CIS and multifocal lesions) stage T1 disease. -------------------------------------------------------------------------------- Reaxys Database Information| --------------------------------------------------------------------------------