Theories about biological limits to life span and evolutionary shaping of human longevity depend on facts about mortality at extreme ages, but these facts have remained a matter of debate. Do hazard curves typically level out into high plateaus eventually, as seen in other species, or do exponential increases persist? In this study, we estimated hazard rates from data on all inhabitants of Italy aged 105 and older between 2009 and 2015 (born 1896–1910), a total of 3836 documented cases. We observed level hazard curves, which were essentially constant beyond age 105. Our estimates are free from artifacts of aggregation that limited earlier studies and provide the best evidence to date for the existence of extreme-age mortality plateaus in humans.

The plateau of human mortality: Demography of longevity pioneers / Barbi, Elisabetta; Lagona, Francesco; Marsili, Marco; Vaupel, James W.; Wachter, Kenneth W.. - In: SCIENCE. - ISSN 0036-8075. - 360:6396(2018), pp. 1459-1461. [10.1126/science.aat3119]

The plateau of human mortality: Demography of longevity pioneers

Barbi, Elisabetta
;
2018

Abstract

Theories about biological limits to life span and evolutionary shaping of human longevity depend on facts about mortality at extreme ages, but these facts have remained a matter of debate. Do hazard curves typically level out into high plateaus eventually, as seen in other species, or do exponential increases persist? In this study, we estimated hazard rates from data on all inhabitants of Italy aged 105 and older between 2009 and 2015 (born 1896–1910), a total of 3836 documented cases. We observed level hazard curves, which were essentially constant beyond age 105. Our estimates are free from artifacts of aggregation that limited earlier studies and provide the best evidence to date for the existence of extreme-age mortality plateaus in humans.
2018
Longevity; extreme ages; Proportional Hazards Models; Gompertz law
01 Pubblicazione su rivista::01a Articolo in rivista
The plateau of human mortality: Demography of longevity pioneers / Barbi, Elisabetta; Lagona, Francesco; Marsili, Marco; Vaupel, James W.; Wachter, Kenneth W.. - In: SCIENCE. - ISSN 0036-8075. - 360:6396(2018), pp. 1459-1461. [10.1126/science.aat3119]
File allegati a questo prodotto
File Dimensione Formato  
Barbi_plateau_2018a.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 252.41 kB
Formato Adobe PDF
252.41 kB Adobe PDF   Contatta l'autore
SCIENCE-2018aSM.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 338.4 kB
Formato Adobe PDF
338.4 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1183693
Citazioni
  • ???jsp.display-item.citation.pmc??? 61
  • Scopus 142
  • ???jsp.display-item.citation.isi??? 119
social impact