Objective Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). Methods EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. Results Widespread sources of delta (<4 Hz) and alpha (8–12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70–75%). Conclusions Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. Significance This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.

Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals / Babiloni, Claudio; Noce, Giuseppe; Pennica, Alfredo; Onorati, Paolo; Capotosto, Paolo; Del Percio, Claudio; Roma, Paolo; Correr, Valentina; Piccinni, Elisa; Toma, Ginevra; Soricelli, Andrea; Di Campli, Francesco; Gianserra, Laura; Ciullini, Lorenzo; Aceti, Antonio; Teti, Elisabetta; Sarmati, Loredana; Crocetti, Gloria; Ferri, Raffaele; Catania, Valentina; Pascarelli, Maria Teresa; Andreoni, Massimo; Ferracuti, Stefano. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 129:2(2018), pp. 431-441. [10.1016/j.clinph.2017.12.002]

Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals

Babiloni, Claudio;Noce, Giuseppe;Pennica, Alfredo;Onorati, Paolo;Capotosto, Paolo;Del Percio, Claudio;Roma, Paolo;Correr, Valentina;Toma, Ginevra;Gianserra, Laura;Ciullini, Lorenzo;Aceti, Antonio;Teti, Elisabetta;Pascarelli, Maria Teresa;Ferracuti, Stefano
2018

Abstract

Objective Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). Methods EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. Results Widespread sources of delta (<4 Hz) and alpha (8–12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70–75%). Conclusions Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. Significance This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1179733
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