This study tested whether resting state alpha rhythms (8-13 Hz) may characterize mild cognitive impairment due to Alzheimer's disease (ADMCI) compared with MCI due to chronic kidney disease (CKDMCI). Clinical and resting state eyes-closed electroencephalographic (rsEEG) rhythms from 40 ADMCI, 29 CKDMCI, and 45 cognitively normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were matched in the three groups, and Mini-Mental State Evaluation (MMSE) score was paired in the ADMCI and CKDMCI groups. Delta (<4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz) cortical sources were estimated by eLORETA freeware and classified across individuals by area under the receiver operating characteristic curve (AUROCC). Compared with Nold group, posterior alpha 1 source activities were more reduced in ADMCI than CKDMCI group. In contrast, widespread delta source activities were greater in CKDMCI than ADMCI group. These source activities correlated with the MMSE score and correctly classified between Nold and all MCI individuals (AUROCC = 0.8-0.85) and between ADMCI and CKDMCI subjects (AUROCC = 0.75). These results suggest that early AD affects cortical neural synchronization at alpha frequencies underpinning brain arousal and low vigilance in the quiet wakefulness. In contrast, CKD may principally affect cortical neural synchronization at the delta frequencies. Future prospective cross-validation studies will have to test these candidate rsEEG markers for clinical applications and drug discovery.

Different abnormalities of cortical neural synchronization mechanisms in patients with mild cognitive impairment due to Alzheimer's and chronic kidney diseases. An EEG study / Lizio, Roberta; Babiloni, Claudio; Del Percio, Claudio; Losurdo, Antonia; Vernò, Lucia; De Tommaso, Marina; Montemurno, Anna; Dalfino, Giuseppe; Cirillo, Pietro; Soricelli, Andrea; Ferri, Raffaele; Noce, Giuseppe; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Famá, Francesco; Orzi, Francesco; Giubilei, Franco; Buttinelli, Carla; Triggiani, A. Ivano; Frisoni, Giovanni B.; Scisci, Anna Maria; Mastrofilippo, Nicola; Procaccini, Deni Aldo; Gesualdo, Loreto. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 65:3(2018), pp. 897-915. [10.3233/JAD-180245]

Different abnormalities of cortical neural synchronization mechanisms in patients with mild cognitive impairment due to Alzheimer's and chronic kidney diseases. An EEG study

Lizio, Roberta;Babiloni, Claudio
;
Del Percio, Claudio;De Tommaso, Marina;Noce, Giuseppe;Pascarelli, Maria Teresa;Famá, Francesco;Orzi, Francesco;Giubilei, Franco;Buttinelli, Carla;
2018

Abstract

This study tested whether resting state alpha rhythms (8-13 Hz) may characterize mild cognitive impairment due to Alzheimer's disease (ADMCI) compared with MCI due to chronic kidney disease (CKDMCI). Clinical and resting state eyes-closed electroencephalographic (rsEEG) rhythms from 40 ADMCI, 29 CKDMCI, and 45 cognitively normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were matched in the three groups, and Mini-Mental State Evaluation (MMSE) score was paired in the ADMCI and CKDMCI groups. Delta (<4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz) cortical sources were estimated by eLORETA freeware and classified across individuals by area under the receiver operating characteristic curve (AUROCC). Compared with Nold group, posterior alpha 1 source activities were more reduced in ADMCI than CKDMCI group. In contrast, widespread delta source activities were greater in CKDMCI than ADMCI group. These source activities correlated with the MMSE score and correctly classified between Nold and all MCI individuals (AUROCC = 0.8-0.85) and between ADMCI and CKDMCI subjects (AUROCC = 0.75). These results suggest that early AD affects cortical neural synchronization at alpha frequencies underpinning brain arousal and low vigilance in the quiet wakefulness. In contrast, CKD may principally affect cortical neural synchronization at the delta frequencies. Future prospective cross-validation studies will have to test these candidate rsEEG markers for clinical applications and drug discovery.
2018
exact low resolution brain electromagnetic source tomography (eLORETA); mild cognitive impairment due to Alzheimer's disease (ADMCI); mild cognitive impairment due to chronic kidney disease (CKDMCI); receiver operating characteristic (ROC) curve; resting state electroencephalographic (rsEEG) rhythms; neuroscience (all); clinical psychology; geriatrics and gerontology; psychiatry and mental health
01 Pubblicazione su rivista::01a Articolo in rivista
Different abnormalities of cortical neural synchronization mechanisms in patients with mild cognitive impairment due to Alzheimer's and chronic kidney diseases. An EEG study / Lizio, Roberta; Babiloni, Claudio; Del Percio, Claudio; Losurdo, Antonia; Vernò, Lucia; De Tommaso, Marina; Montemurno, Anna; Dalfino, Giuseppe; Cirillo, Pietro; Soricelli, Andrea; Ferri, Raffaele; Noce, Giuseppe; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Famá, Francesco; Orzi, Francesco; Giubilei, Franco; Buttinelli, Carla; Triggiani, A. Ivano; Frisoni, Giovanni B.; Scisci, Anna Maria; Mastrofilippo, Nicola; Procaccini, Deni Aldo; Gesualdo, Loreto. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 65:3(2018), pp. 897-915. [10.3233/JAD-180245]
File allegati a questo prodotto
File Dimensione Formato  
Lizio_Different-Abnormalities_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 581.68 kB
Formato Adobe PDF
581.68 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1179591
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 11
social impact