In this hospital-based, multicenter case-control study we investigated the prevalence of hepatitis B virus (HBV)-related markers and HBV/hepatitis C virus (HCV) co-infection among B-cell non-Hodgkin's lymphoma (B-NHL) cases and controls. Four hundred newly diagnosed B-NHL cases and 392 controls from other departments of the same hospitals were studied. The prevalence of positivity for hepatitis B surface antigen (HBsAg) was 8.5% among B-NHL cases and 2.8% among controls (adjusted odds ratio, 3.67; 95% confidence interval, 1.75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and B-NHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL.
High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma. Haematologica / Marcucci, F; Mele, A; Spada, E; Candido, A; Bianco, E; Pulsoni, Alessandro; Chionne, P; Madonna, E; Cotichini, R; Barbui, A; De Renzo, A; Dore, F; Iannitto, ; Liso, V; Martino, B; Montanaro, M; Pagano, L; Musto, P; Rapicetta, M.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 91:(2006), pp. 554-557.
High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma. Haematologica.
PULSONI, Alessandro;
2006
Abstract
In this hospital-based, multicenter case-control study we investigated the prevalence of hepatitis B virus (HBV)-related markers and HBV/hepatitis C virus (HCV) co-infection among B-cell non-Hodgkin's lymphoma (B-NHL) cases and controls. Four hundred newly diagnosed B-NHL cases and 392 controls from other departments of the same hospitals were studied. The prevalence of positivity for hepatitis B surface antigen (HBsAg) was 8.5% among B-NHL cases and 2.8% among controls (adjusted odds ratio, 3.67; 95% confidence interval, 1.75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and B-NHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL.| File | Dimensione | Formato | |
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