Metformin is currently the most widely used drug worldwide for the treatment of type 2 diabetes (T2DM) in adults. Its primary action appears to be the inhibition of hepatic glucose production and the increase in peripheral insulin sensitivity (1). Due to the worldwide increase of pediatric obesity and its related complications (2-4), the adoption of treatment with metformin has significantly increased in children and adolescents. Whereas only short-term data are available on the benefits of metformin in obese children and adolescents with insulin resistance and normal glucose tolerance (5), metformin therapy in adolescents affected by T2DM is well established (6). Metformin is also beneficial in girls with polycystic ovarian syndrome (PCOS) (7). Moreover, the use of metformin has been recently extended to other conditions with promising results (8-10). This review summarizes scientific evidences and practical considerations for the use of metformin in the treatment of different diseases affecting children and adolescents.
Use of metformin in pediatric age / Brufani, C; Fintini, D; Nobili, V; Patera, Pi; Cappa, M; Brufani, M.. - In: PEDIATRIC DIABETES. - ISSN 1399-543X. - 12:6(2011), pp. 580-588. [10.1111/j.1399-5448.2010.00741.x]
Use of metformin in pediatric age
Nobili V;
2011
Abstract
Metformin is currently the most widely used drug worldwide for the treatment of type 2 diabetes (T2DM) in adults. Its primary action appears to be the inhibition of hepatic glucose production and the increase in peripheral insulin sensitivity (1). Due to the worldwide increase of pediatric obesity and its related complications (2-4), the adoption of treatment with metformin has significantly increased in children and adolescents. Whereas only short-term data are available on the benefits of metformin in obese children and adolescents with insulin resistance and normal glucose tolerance (5), metformin therapy in adolescents affected by T2DM is well established (6). Metformin is also beneficial in girls with polycystic ovarian syndrome (PCOS) (7). Moreover, the use of metformin has been recently extended to other conditions with promising results (8-10). This review summarizes scientific evidences and practical considerations for the use of metformin in the treatment of different diseases affecting children and adolescents.File | Dimensione | Formato | |
---|---|---|---|
Brufani_Use of metformin_2011.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
510.23 kB
Formato
Adobe PDF
|
510.23 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.