Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries, and its prevalence is increasing worldwide. It currently affects approximately 30% of adults and 10% of children and adolescents. The resulting increase in the number of patients with NAFLD is expected to translate into increased numbers of patients with liver cirrhosis, and hepatocellular carcinoma. In this context, it is particularly important to identify patients at risk for progressive chronic liver disease. Currently, liver biopsy is the gold standard to diagnose non-alcoholic steatohepatitis (NASH) and to establish the presence and stage of fibrosis. Due to the remarkable increase in the prevalence of NAFLD and the concomitant efforts in developing novel therapies for patients with NASH, non-invasive, simple, reproducible, and reliable non-invasive methodologies are needed. This paper provides a concise overview of the role of non-invasive diagnostic tools for the determination of presence and extent of fibrosis in NAFLD patients, with particular emphasis on the methods currently available in clinical practice.

Non-invasive assessment of fibrosis in non-alcoholic fatty liver disease / Vizzutti, F; Arena, U; Nobili, V; Tarquini, R; Trappoliere, M; Laffi, G; Marra, F; Pinzani, M.. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 8:2(2009), p. 89-94.

Non-invasive assessment of fibrosis in non-alcoholic fatty liver disease

Nobili V;
2009

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries, and its prevalence is increasing worldwide. It currently affects approximately 30% of adults and 10% of children and adolescents. The resulting increase in the number of patients with NAFLD is expected to translate into increased numbers of patients with liver cirrhosis, and hepatocellular carcinoma. In this context, it is particularly important to identify patients at risk for progressive chronic liver disease. Currently, liver biopsy is the gold standard to diagnose non-alcoholic steatohepatitis (NASH) and to establish the presence and stage of fibrosis. Due to the remarkable increase in the prevalence of NAFLD and the concomitant efforts in developing novel therapies for patients with NASH, non-invasive, simple, reproducible, and reliable non-invasive methodologies are needed. This paper provides a concise overview of the role of non-invasive diagnostic tools for the determination of presence and extent of fibrosis in NAFLD patients, with particular emphasis on the methods currently available in clinical practice.
2009
Adolescent; Adult; Biomarkers; Biopsy; Child; Elasticity Imaging Techniques; Fatty Liver; Humans; Liver Cirrhosis; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; Severity of Illness Index
01 Pubblicazione su rivista::01a Articolo in rivista
Non-invasive assessment of fibrosis in non-alcoholic fatty liver disease / Vizzutti, F; Arena, U; Nobili, V; Tarquini, R; Trappoliere, M; Laffi, G; Marra, F; Pinzani, M.. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 8:2(2009), p. 89-94.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1177923
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