The IL7 receptor a chain, encoded by the IL7R gene, heterodimerizes with the IL-2Rc (common gamma) chain to form the IL7 receptor, or with the cytokine receptor-like factor 2 (CRLF2) for the thymic stromal lymphopoietin (TSLP) receptor, in both B and T cells . Signals from the IL7 and TSLP receptors activate the JAK/STAT and PI3K/Akt/mTOR pathways, and are essential for the normal development and maintenance of the immune system
IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies / Gianfelici, V; Messina, M; Paoloni, F; Peragine, N; Lauretti, A; Fedullo, Al; Di Giacomo, F; Vignetti, M; Vitale, A; Guarini, A; Chiaretti, S; Foà, R.. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - (2018), pp. 1-4-4. [10.1080/10428194.2018.1499906]
IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies
Messina M;Peragine N;Lauretti A;Vignetti M;Guarini A;Chiaretti S;Foà R.
2018
Abstract
The IL7 receptor a chain, encoded by the IL7R gene, heterodimerizes with the IL-2Rc (common gamma) chain to form the IL7 receptor, or with the cytokine receptor-like factor 2 (CRLF2) for the thymic stromal lymphopoietin (TSLP) receptor, in both B and T cells . Signals from the IL7 and TSLP receptors activate the JAK/STAT and PI3K/Akt/mTOR pathways, and are essential for the normal development and maintenance of the immune systemI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
