An epidemiological retrospective study and a recent prospective study from Finland have both concluded that vitamin D3 supplementation at birth protects individuals from type 1 diabetes later in life. Moreover, it is thought that vitamin D3 supplementation, in particular its activated form, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], may act as an immunomodulator, facilitating the shift from a Th1 to a Th2 immune response. The aim of this surveillance study was to measure levels of both 25-hydroxyvitamin D3 (25OHD3) and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes as compared to normal subjects.
Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes / Pozzilli, P; Manfrini, S; Crinò, A; Picardi, A; Leomanni, C; Cherubini, V; Valente, L; Khazrai, M; Visalli, N; Coppolino G., E; Guglielmi C., E; Anguissola G. B., E; Costanza F., E; Montemari A. L., E; Cavallo, Mg; Schiaffini, R.; Lauria, A.; Cipolloni, L.; Matteoli, M. C.; Patera, P.; Corbi, S.; Spera, S.; Suraci, C; Cervoni, M.; De, Mattia; Cassone Faldetta, M. R.; Manca, Bitti; M. L., Bizzarri; C., Cappa; M., Pitocco; D., Ghirlanda. - In: HORMONE AND METABOLIC RESEARCH. - ISSN 0018-5043. - STAMPA. - 37:11(2005), pp. 680-683. [10.1055/s-2005-870578]
Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes
Cavallo MG;
2005
Abstract
An epidemiological retrospective study and a recent prospective study from Finland have both concluded that vitamin D3 supplementation at birth protects individuals from type 1 diabetes later in life. Moreover, it is thought that vitamin D3 supplementation, in particular its activated form, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], may act as an immunomodulator, facilitating the shift from a Th1 to a Th2 immune response. The aim of this surveillance study was to measure levels of both 25-hydroxyvitamin D3 (25OHD3) and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes as compared to normal subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
