In this work, a numerical study of the interaction of an electromagnetic field with a biological cell in the different phases of mitosis is presented. In particular, the validity of the single-shell model during mitosis from a geometrical viewpoint has been considered.We consider the Jurkat cell for our analysis and model the content of the cell, composed by the nucleus and different organelles immersed in cytoplasm and delimited by the cellmembrane, as a singlematerial with appropriate electromagnetic properties derived by making use of effective medium approximation methods, i.e., we used a quasistatic approach to deal with the cell. To validate the model, a comparison between the original and 2 approximated geometry models is made and the results are in very good accordance. Subsequently, an analysis of the scattered field indicates that the most sensitive component to the mitosis phase is the one parallel to the segment joining the centers of the cells.

Numerical analysis of electromagnetic interactions by a cell during the mitosis phases / Mangini, F.; Muzi, M.; Frezza, F.. - In: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING. - ISSN 2040-7939. - 34:9(2018), pp. 1-11. [10.1002/cnm.3110]

Numerical analysis of electromagnetic interactions by a cell during the mitosis phases

F. Mangini;M. Muzi;F. Frezza
2018

Abstract

In this work, a numerical study of the interaction of an electromagnetic field with a biological cell in the different phases of mitosis is presented. In particular, the validity of the single-shell model during mitosis from a geometrical viewpoint has been considered.We consider the Jurkat cell for our analysis and model the content of the cell, composed by the nucleus and different organelles immersed in cytoplasm and delimited by the cellmembrane, as a singlematerial with appropriate electromagnetic properties derived by making use of effective medium approximation methods, i.e., we used a quasistatic approach to deal with the cell. To validate the model, a comparison between the original and 2 approximated geometry models is made and the results are in very good accordance. Subsequently, an analysis of the scattered field indicates that the most sensitive component to the mitosis phase is the one parallel to the segment joining the centers of the cells.
2018
biological cells; cell mitosis; electromagnetic interaction; FEM; homogenization model; lossy media
01 Pubblicazione su rivista::01a Articolo in rivista
Numerical analysis of electromagnetic interactions by a cell during the mitosis phases / Mangini, F.; Muzi, M.; Frezza, F.. - In: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING. - ISSN 2040-7939. - 34:9(2018), pp. 1-11. [10.1002/cnm.3110]
File allegati a questo prodotto
File Dimensione Formato  
Mangini_numerical-analysis_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.44 MB
Formato Adobe PDF
1.44 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1173600
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact