Innate immune receptors, well known mediators of response to non-self-molecules and inflammation, also act as mediators of immunity triggered by ‘damage-associated molecular patterns’ (DAMPs). Pathogen-associated molecular patterns (PAMPs) cause inflammation in mammals and a rapid immune response in plants, while DAMPs trigger more complex responses, including immunity, tissue maintenance and repair. DAMPs, their receptors and downstream transduction mechanisms are often conserved within a kingdom or, due to convergent evolution, are similar across the kingdoms of life. Herein, we describe the dynamics and functionality of specific extracellular DAMP classes and their receptors in immunity, inflammation and repair of tissue damage in plants and mammals.

Extracellular DAMPs in plants and mammals: immunity, tissue damage and repair / De Lorenzo, G; Ferrari, S; Cervone, F; Okun, E.. - In: TRENDS IN IMMUNOLOGY. - ISSN 1471-4906. - 39:11(2018), pp. 937-950. [10.1016/j.it.2018.09.006]

Extracellular DAMPs in plants and mammals: immunity, tissue damage and repair

De Lorenzo G
;
Ferrari S;Cervone F;
2018

Abstract

Innate immune receptors, well known mediators of response to non-self-molecules and inflammation, also act as mediators of immunity triggered by ‘damage-associated molecular patterns’ (DAMPs). Pathogen-associated molecular patterns (PAMPs) cause inflammation in mammals and a rapid immune response in plants, while DAMPs trigger more complex responses, including immunity, tissue maintenance and repair. DAMPs, their receptors and downstream transduction mechanisms are often conserved within a kingdom or, due to convergent evolution, are similar across the kingdoms of life. Herein, we describe the dynamics and functionality of specific extracellular DAMP classes and their receptors in immunity, inflammation and repair of tissue damage in plants and mammals.
2018
DAMPs; extracellular matrix; innate immunity; pattern recognition receptors; Immunology and Allergy; Immunology
01 Pubblicazione su rivista::01a Articolo in rivista
Extracellular DAMPs in plants and mammals: immunity, tissue damage and repair / De Lorenzo, G; Ferrari, S; Cervone, F; Okun, E.. - In: TRENDS IN IMMUNOLOGY. - ISSN 1471-4906. - 39:11(2018), pp. 937-950. [10.1016/j.it.2018.09.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1173065
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